Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (3)
  • 2000-2004  (3)
Source
  • Articles: DFG German National Licenses  (3)
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 89 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The mitochondrial permeability transition (mPT) is increasingly implicated in neuronal cell death. In the present study, isolated respiring brain mitochondria were examined for their ability to undergo calcium-induced mPT and their sensitivity to mPT inhibition by cyclosporin A (CsA). Previous studies have suggested a heterogeneous response to calcium, a limitation of CsA inhibition, and a relative resistance in the ability of respiring brain mitochondria to undergo mPT. Using fluorometric and electron microscopic analyses, we found that virtually the whole population of respiring brain mitochondria readily undergo mPT and swell upon calcium exposure. Further, brain mitochondria were highly sensitive to CsA which potentiated morphological recovery after transient swelling as well as completely blocked mPT induction in the presence of a low concentration of ADP. Using flow cytometry, which allows analysis of individual mitochondria, we demonstrate that both brain and liver mitochondria display homogeneous responses to calcium-induced mPT. We conclude that the mPT is one likely target for the broad in vivo neuroprotective effects displayed by CsA when allowed to penetrate the blood–brain barrier, and that development of compounds inhibiting mPT may prove beneficial for the treatment of severe brain disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02400.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 425 (2003), S. 407-410 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signalling proteins, including HER-2/ErbB2, Akt, Raf-1, Bcr-Abl and mutated p53. Hsp90 inhibitors bind to Hsp90, and induce the proteasomal degradation of Hsp90 client ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01913
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    V-Market: A framework for agent e-commerce systems (2000)
    Springer
    World wide web 3 (2000), S. 43-52 
    Details
    ISSN: 1573-1413
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Software agent technology is still an emerging technology, and as such, agent based software design is still in its infancy. Software agents have just started to be used in the e-commerce domain, and they are already beginning to create a series of new possibilities for this arena. Agents can be used to automate, as well as to enhance many stages of the traditional consumer-buying behavior process. This paper proposes a software engineering approach to the design of agent mediated e-commerce systems, through the definition of an object-oriented framework. The paper presents the underlying concepts, and the architecture of the environment, showing how it allows developers to customize virtual marketplaces, and to define transaction categories on demand, incorporating many possible products and services that can be traded online.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019273427930
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...