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  • Articles: DFG German National Licenses  (4)
  • 1995-1999  (3)
  • 1990-1994  (1)
  • Polymer and Materials Science  (2)
  • Pravastatin  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of pravastatin on plasma and urinary mevalonate concentrations in subjects with familial hypercholesterolaemia: a comparison of morning and evening administration (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 361-364 
    Details
    ISSN: 1432-1041
    Keywords: Hypercholesterolaemia ; Pravastatin ; Mevalonate ; cholesterol synthesis ; circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In order to determine whether there is a difference in the effect of the hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor pravastatin on cholesterol synthesis between the morning and the evening, we studied the 24-h profile of mevalonate in plasma and urine in 11 subjects with heterozygous familial hypercholesterolaemia. In study 1, eight subjects with familial hypercholesterolaemia took pravastatin (20 mg) once in the morning, and another 20-mg dose in the evening after a 1-week wash-out period. In study 2, five subjects with familial hypercholesterolaemia took pravastatin (20 mg per day) in the morning on 3 consecutive days and on 3 days in the evening after a 1 day wash-out. Plasma mevalonate concentrations were reduced at 9 h and 5 h after pravastatin administration in the morning and the evening, respectively. Urinary mevalonate excretion was significantly reduced at 4–8 h after pravastatin administration in the morning (51 vs 19 nmol · h−1) and at 4–16 h after pravastatin administration in the evening (56 vs 27 nmol · h−1). Daily urinary mevalonate excretion was equally and significantly reduced by pravastatin in the morning or evening. In conclusion, we found that morning and evening administration of pravastatin caused equal reductions in plasma and urinary mevalonate concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203778
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of pravastatin on plasma and urinary mevalonate concentrations in subjects with familial hypercholesterolaemia: a comparison of morning and evening administration (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 361-364 
    Details
    ISSN: 1432-1041
    Keywords: Key words Hypercholesterolaemia ; Pravastatin ; Mevalonate; cholesterol synthesis ; circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In order to determine whether there is a difference in the effect of the hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor pravastatin on cholesterol synthesis between the morning and the evening, we studied the 24-h profile of mevalonate in plasma and urine in 11 subjects with heterozygous familial hypercholesterolaemia. In study 1, eight subjects with familial hypercholesterolaemia took pravastatin (20 mg) once in the morning, and another 20-mg dose in the evening after a 1-week wash-out period. In study 2, five subjects with familial hypercholesterolaemia took pravastatin (20 mg per day) in the morning on 3 consecutive days and on 3 days in the evening after a 1 day wash-out. Plasma mevalonate concentrations were reduced at 9 h and 5 h after pravastatin administration in the morning and the evening, respectively. Urinary mevalonate excretion was significantly reduced at 4–8 h after pravastatin administration in the morning (51 vs 19 nmol ⋅h−1) and at 4–16 h after pravastatin administration in the evening (56 vs 27 nmol ⋅h−1). Daily urinary mevalonate excretion was equally and significantly reduced by pravastatin in the morning or evening. In conclusion, we found that morning and evening administration of pravastatin caused equal reductions in plasma and urinary mevalonate concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050032
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Recognition of amino acids by membrane potential of immobilized globulin membranes (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 55 (1995), S. 343-349 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The shifts in membrane potential, caused by the injection of some amino acids into a permeation cell, were measured using immoblized γ-globulin membranes. The shifts in membrane potential were observed to be positive or negative when the isoelectric point of each amino acid injected into the cell was less or higher than 6.0. The potential response caused by the injection of each amino acid shows an individual and characteristic curve depending on the amino acid, and the difference in potential curves between D-aspartic acid and L-aspartic acid is significantly observed in the immobilized γ-globulin membranes. The t3/4 value was found to increase in the following order: lysine = glutamic acid 〈arginine 〈 D-aspartic acid = asparagine 〈 L-aspartic acid 〈 histidine 〈 alanine, where t3/4 indicates the time at which 75% of the shifts in membrane potential has been observed. The modified membrane potential theory provides satisfactory explanations for the membrane potential obtained experimentally before and after the injection of L-alanine, and the theoretical shifts can explain the experimental shifts in membrane potential due to the injection of L-alanine into the cell. © 1995 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070550216
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Bromination and gas permeability of poly(1-trimethylsilyl-1-propyne) membrane (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 54 (1994), S. 1207-1217 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The bromination of poly(1-trimethylsilyl-1-propyne) (PMSP) was carried out by immersing a PMSP membrane in bromine water at 25°C. The bromine mainly reacted at the carbon-carbon double bonds in the backbone chain, and carbon-carbon single bonds were produced, which was determined from the infrared (IR) and ultravilet (UV)-visible analyses. The glass transition temperature of the PMSP is above 350°C, but a new endothermic peak appeared between 50 and 80°C in the differential scanning calorimetry (DSC) curves of all brominated PMSPs. The permeability for 12 gases in the PMSP membrane and its brominated membranes was investigated between 30 and 90°C below 1 atm. With increasing bromine content in the membrane, the permeability coefficient for all gases decreased together with the diffusion coefficient, and the ideal separation factor for the industrially important gas pairs increased at 30°C. A distinct change in slopes at near the endothermic temperature determined by the DSC analysis was observed in Arrhenius plots of the permeability coefficients in all brominated PMSP membranes. © 1994 John Wiley & Sons, Inc.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1994.070540903
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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