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  • 1
    Electronic Resource
    Electronic Resource
    Ion-sputtering atomic beam source for high-resolution laser spectroscopy of refractory elements (1993)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 3487-3491 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A high-resolution laser spectroscopy system for refractory elements with an argon-ion- sputtering atomic beam source was constructed, and it has been demonstrated that the sputtering method is extremely useful as an atomic beam source for high-resolution laser spectroscopy to measure hyperfine structures and isotope shifts for refractory elements, such as Hf, Ta, and W. This source produced intense neutral atomic beams of more than 1010 atoms/s for these elements, and the yield was easily controlled by adjusting the argon-ion current and the acceleration voltage. Resonance linewidths were 32, 66, and 48 MHz for Hf, Ta, and W, respectively, which are sufficient to measure the hyperfine structures and the isotope shifts in optical transitions. With this system, the signal-to-noise ratio reached more than 106. In addition, the temperature of the sputtered atoms found was rather low compared to the kinetic energy given to the atoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1144457
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  • 2
    Electronic Resource
    Electronic Resource
    Heterogeneity of antibody specificity in Taiwanese patients with polyneuropathy and IgM paraproteinemia (1998)
    Springer
    Journal of biomedical science 5 (1998), S. 441-445 
    Details
    ISSN: 1423-0127
    Keywords: Polyneuropathy ; Gammopathy ; Myelin-associated glycoprotein ; Sulfoglucuronosyl glycolipids ; Sulfoglucuronosyl paragloboside ; Sulfoglucuronosyl lactosaminyl paragloboside ; Autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract About half of the Caucasian patients with chronic polyneuropathy and IgM paraproteinemia show serum anti-myelin-associated glycoprotein (MAG) and anti-sulfoglucuronosyl glycosphingolipid (SGGLs) activities. These antibody activities have been demonstrated to react with a carbohydrate epitope known as the HNK-1 or sulfoglucuronic acid (SGA) epitope. However, in Asian populations the occurrence of serum anti-SGA activities has been reported to be relatively rare. We investigated 5 cases of chronic polyneuropathy with IgM paraproteinemia from Taiwan and found that 3 of them had high-titer serum anti-SGA (SGGL/MAG) antibody activities. The clinical symptoms of these 3 patients were consistent with sensory dominant polyneuropathy with a severer involvement of the lower limbs than of the upper limbs. Electromyography and nerve conduction studies revealed severe sensory nerve involvement (no response in 3 cases) and moderate slowing of motor conduction velocity (MCV) without conduction block. The decrease in MCV correlated well with anti-SGA antibody titer (less than 30 m/s with the titration of 1:12,800, normal 55–60 m/s). Pathological findings showed active demyelinating polyneuropathy with myelin ovoid and myelinated fiber loss. Our data suggest that anti-SGGL antibody activities may not be very rare among Asian populations. Additionally, there seems an intriguing possibility that the titer of this antibody correlates with the severity of peripheral nerve involvement in patients of demyelinating polyneuropathy with IgM paraproteinemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02255933
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  • 3
    Electronic Resource
    Electronic Resource
    Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis? (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 507-508 
    Details
    ISSN: 1432-1076
    Keywords: High dose intravenous gammaglobulin therapy ; Haemolytic disease of newborn ; Rhesus incompatibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c+E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958434
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  • 4
    Electronic Resource
    Electronic Resource
    A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 313-315 
    Details
    ISSN: 1432-1076
    Keywords: X-linked auto-immune enteropathy ; Haemo lytic anaemia ; Polyendocrinopathy ; Cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three cases of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy are described from one related Japanese kindred. Two boys had died due to severe diarrhoea accompanied by total or subtotal intestinal villous atrophy.In contrast, although one patient showed the same symptoms and had circulating IgG antibodies against enterocytes, his condition improved dramatically and he developed well following the use of cyclosporin A (CSA). CSA may be beneficial in patients with this rare disorder. Auto-immune enteropathy should be considered as a cause of protracted diarrhoea with unknown aetiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956741
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  • 5
    Electronic Resource
    Electronic Resource
    A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 469-472 
    Details
    ISSN: 1432-1076
    Keywords: X-linked chronic granulomatous disease ; Mutant cytochrome b heavy chain ; Point mutation ; Molecular genetic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Molecular genetic analysis was performed in a patient with cytochrome b positive X-linked chronic granulomatous disease. A previous Southern blot study, using a cytochrome b heavy chain cDNA as probe, revealed a Pst I restriction fragment pattern for the cytochrome b heavy chain gene (CYBB) different to that of normal individuals. Since restriction length polymorphism with Pst I has never been observed in control individuals and no abnormal restriction fragment patterns in the patient's CYBB was detected with seven other enzymes used, we focussed on the single Pst I site in the CYBB cDNA as being the only mutation site responsible for his disease. A fragment of the patient's cDNA which included the Pst I site was amplified by reverse polymerase chain reaction, and loss of the Pst I site in the fragment was confirmed by incubation with Pst I. Subsequent sequence analysis of the fragment revealed a point mutation in the Pst I site (cytosine to adenine), substituting glutamic acid for alanine at position 57.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955051
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The α-decay energies and halflives of 195g,mAt and 199Fr (1999)
    Springer
    The European physical journal 5 (1999), S. 123-125 
    Details
    ISSN: 1434-601X
    Keywords: PACS: 23.60.+e nbsp;decay – 25.70.Gh Compound nucleus – 27.80.+w 190 ≤ A ≤ 219
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The α-decay energy and halflife of 195mAt were determined to be 6960±20 keV and 385+69 −51 ms respectively, on the basis of genetic correlations in the 169Tm(36Ar, α6n)195At reaction, while those of 195gAt measured simultaneously were 7105±30 keV and 146+21 −17 ms respectively, reconfirming the previously reported values. A new isotope 199Fr was also produced and identified in the same way in the 169Tm(36Ar, 6n)199Fr reaction, yielding Eα= 7655±40 keV and T1/2= 12+10 −4 ms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500050266
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  • 7
    Electronic Resource
    Electronic Resource
    Isotope shift and hyperfine structure of refractory elements by laser spectroscopy with sputtered atomic beams (1994)
    Springer
    Hyperfine interactions 84 (1994), S. 365-369 
    Details
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Ar-ion sputtering is successfully used to produce intense atomic beams of refractory elements. The population in the ground and low metastable states of Ta 1 is investigated for the sputtered atoms. Isotope shifts and hyperfine structures of seven transitions have been measured for the stable isotopes of Hf, Ta and W. The hyperfine coupling constantsA andB are determined for eight atomic levels of177,179Hf,181Ta and183W.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060684
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