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  • Articles: DFG German National Licenses  (56)
  • 1995-1999  (40)
  • 1985-1989  (16)
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  • Articles: DFG German National Licenses  (56)
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  • 1
    Electronic Resource
    Electronic Resource
    Effects of GABAergic Drugs In Vivo on High-Affinity Choline Uptake In Vitro in Mouse Hippocampal Synaptosomes (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 47 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of several γ-aminobutyric acid (GABA)-ergic drugs on sodium-dependent high-affinity choline uptake (HACU) were investigated in the hippocampus. HACU was measured in vitro after in vivo administration of the drug to mice. HACU was inhibited by those drugs that enhance GABA transmission. The convulsant 3-mercaptopropionic acid, which decreases GABA levels, stimulated HACU. From these results and previous find ings, it appears that GABA mediates a tonic inhibitory effect on the septal-hippocampal cholinergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb13107.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Tyrosine Kinase Inhibitor Genistein Increases Endogenous Dopamine Release from Normal and Weaver Mutant Mouse Striatal Slices (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Protein tyrosine kinases that are known to have major roles in the control of cell growth and transformation are abundant and have numerous phosphoprotein substrates in the adult CNS. Although less well characterized than serine/threonine kinases, tyrosine kinases are also concentrated in the synapse. The effect of genistein, a selective inhibitor of tyrosine kinase activity, was examined on the in vitro release of endogenous dopamine (DA) from superfused mouse striatal slices. Fractional release of DA was significantly increased over basal release levels by genistein (100 and 200 µM). The effect was concentration dependent and rapidly reversible on washout of the kinase inhibitor. No significant change from basal release levels was observed with two structural analogues of genistein that do not inhibit tyrosine kinase activity at the same concentration. We have previously described alterations in basal and evoked DA release from the striatum of the weaver (wv/wv) mutant mouse, and genotypic differences in fractional release were also observed with genistein stimulation. The total evoked release was 25–50% greater from the wv/wv striatum. These results suggest a modulatory role for tyrosine kinase activity in neurotransmitter release and perhaps an alteration of kinase-regulated mechanisms in the DA-deficient wv/wv striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65052096.x
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  • 3
    Electronic Resource
    Electronic Resource
    Dopamine Transporter-Dependent and -Independent Endogenous Dopamine Release from Weaver Mouse Striatum In Vitro (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The weaver mutant mouse (wv/wv) has an ∼70% loss of nigrostriatal dopamine (DA) neurons, but the fractional DA release evoked by amphetamine (but not a high potassium level) has been shown to be greater from striatal slices of the weaver compared with +/+ mice. In the present work we tested the hypothesis that fractional DA release from weaver striatum would be greater when release was mediated by the DA transporter. Serotonin (5-HT)-stimulated fractional DA release was greater from weaver than from +/+ striatum. The release evoked by 5-HT in the presence of 10 µM nomifensine (an antagonist of the DA transporter) was less than in its absence, but the difference between weaver and +/+ striatum remained. In the presence of nomifensine, 1-(m-chlorophenyl)biguanide, classified as a 5-HT3 agonist, also induced a greater fractional release from weaver compared with +/+ striatum. When veratridine was used at a low concentration (1 µM), the fractional evoked release of DA was higher from the weaver in the presence and absence of nomifensine. These findings suggest that the reason for the difference in the responsiveness of the two genotypes to these release-inducing agents is not related to DA transporter function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64010191.x
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrogen mineralization in loamy arable soils after increasing the ploughing depth and ploughing grasslands (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 5 (1989), S. 0 
    Details
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Increasing the ploughing depth and ploughing in grassland has been common in Germany during the past 20 years. Incubation studies were conducted with topsoils from luvisols and gleysols at different times after change of management in order to assess its influence on nitrogen mineralization and its kinetic parameters.The results show that deep ploughing slows the mineralization of nitrogen. The difference between earlier (1967–72) and more recently (1980–82) deepened topsoil has become smaller after a further three years of cultivation, however. The preceding crops (wheat or sugar beet), the amount of N fertilizer as well as clay and nitrogen contents cause a variation in N mineralization. The results indicate a continuing approach of an‘equilibrium’organic matter and nitrogen content. The enrichment capacity of intensively managed soils may be replenished within 10 years.Gleysols formerly under grass mineralize more nitrogen than‘traditionally’ploughed soils, even 27 years after the ploughing-in. While nitrogen from easily decomposable materials decreases within the first 10 years, the resistant fraction is a long-lasting determinant for N mineralization. Both processes need to be considered when applying fertilizer to minimize nitrate leaching.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1475-2743.1989.tb00779.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Spatial Dependence of Check Plot Yield and Local Control (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 103 (1989), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: For maximizing genetic gains, with given resources, plant breeders generally conduct large but un- or inadequately-replicated field trials especially during early generation evaluations and population improvement programmes. Checks arc often used to improve the precision of test plot comparisons. Adjustments by moving or weighted means etc. arc, however, empirical or based on assumptions too difficult to verify. An alternative stochastically best linear unbiased optimal locally weighted method of spatial prediction of micro-environmental heterogeneity indices of treatment plots was examined. Two checks used in an unreplicated evaluation of 1560 test lines of winter wheat expressed the micro-environmental variation in similar ways. About 46, 38 and 16 percent of the total variation in yield was a simple row and column effects, spatially dependent, and random errors, respectively. Optimal weights derived to simulate the micro-environmental heterogeneity indices were sensitive to the position of the test plot and thus provided a better local control. The model was validated, and prediction standard deviations of simulations computed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1989.tb00387.x
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  • 6
    Electronic Resource
    Electronic Resource
    Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis (1999)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 13 (1999), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD).〈section xml:id="abs1-2"〉〈title type="main"〉Methods: 214 patients with symptomatic, non-erosive GERD (moderate to severe daytime and/or night-time heartburn greater than half the days over the past 6 months and during the 7- to 10-day pre-treatment period) were randomized to either lansoprazole 15 mg or lansoprazole 30 mg, or placebo o.d. for 8 weeks.〈section xml:id="abs1-3"〉〈title type="main"〉Results: Daily diary data indicated that on the first treatment day a statistically significantly smaller percentage of lansoprazole patients reported daytime and night-time heartburn and antacid usage, compared with placebo patients. Lansoprazole patients also reported statistically significant less severe daytime and night-time heartburn on the first treatment day. During 0–4, 4–8, and 0–8 weeks of therapy, a statistically significant smaller percentage of days and nights with heartburn, less severe daytime and night-time heartburn, and less antacid usage were observed in the lansoprazole group compared to the placebo group. The percentages of patients with adverse reactions were similar in the lansoprazole and placebo groups.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions: The results of this study demonstrate that lansoprazole is an appropriate therapy for patients with symptomatic non-erosive GERD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1999.00558.x
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  • 7
    Electronic Resource
    Electronic Resource
    Pulsoximeter während der kardiopulmonalen Reanimation (1997)
    Springer
    Notfall + Rettungsmedizin 0 (1997), S. 34-37 
    Details
    ISSN: 1436-0578
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: 2 -Sättigungswerte zulassen und welche Konsequenzen sich aus diesen Erkenntnissen ergeben. Die Untersuchung zeigt, daß die Pulsoximetrie zur Qualitätskontrolle der durchgeführten Wiederbelebungsmaßnahmen in einem hohen Prozentsatz geeignet erscheint. Es werden die beeinflußbaren physikalischen Parameter der Reanimation aufgeführt. Die Pulsoximetrie stellt eine sinnvolle Überwachungsmaßnahme unter der Reanimation dar und sollte so früh wie möglich eingesetzt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010996
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  • 8
    Electronic Resource
    Electronic Resource
    Möglichkeiten und Grenzen der funktionell konservativen Therapie akuter Achillessehnenrupturen (1997)
    Springer
    Der Chirurg 68 (1997), S. 517-524 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Achilles tendon ; Tendon surgery ; Non-operative treatment ; Early mobilisation ; Ultrasound ; Isokinetic muscle strength. ; Schlüsselwörter: Achillessehne ; Sehnennaht ; konservative Therapie ; Sonographie ; isokinetische Muskelkraftmessung.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. In einem 2,5 jährigen Zeitraum wurden 55 Patienten mit einer frischen Achillessehnenruptur (ASR) nach definierten sonographischen Kriterien operativ und funktionell konservativ behandelt. Durchschnittlich 2,4 Jahre später konnten von 51 Patienten (operative Gruppe = 28 Patienten, konservative Gruppe = 23 Patienten) erneut klinische, funktionelle sowie isokinetische Daten der eingelenkigen Plantarflexoren erfaßt werden. Während in der operativen Gruppe insgesamt bei 10,6 % Wundheilungsstörungen mit spontanem Heilungsverlauf auftraten, betrug die Rerupturrate in der konservativen Gruppe 13 %. Die Incidenz an Achillodynien war zum Nachuntersuchungszeitpunkt in der nicht operativen Gruppe deutlich höher (p = 0,019). Durch die Cybextestung wurden durchschnittliche Kraftdefizite in der operativen Gruppe von 13,7 % und nach funktionell konservativer Behandlung von 24,7 % (p = 0,012) festgestellt. Während die Adaptationsnaht i. d. R. zum Erfolg führt, ist die Indikation zur konservativen Therapie der ASR von der Sehnendiastase, dem Aktivitätswunsch und der Kooperation abhängig.
    Notes: Summary. According to sonographic criteria, 55 patients underwent surgical treatment with mobilisation in a lower leg plaster or conservative treatment with early mobilisation in heel pad (3 cm) shoes when an acute Achilles tendon rupture (ATR) was diagnosed. The follow-up period in 51 patients was 2.4 years (operated group = 28 patients, conservative group = 23 patients) with clinical examination and testing of isokinetic muscle strength in knee joint flexion. After surgical treatment, minor wound infections occurred in 10.6 %. Reruptures occurred in 13 % of the conservative group. Following conservative treatment, the rate of stress-related achillodynia was significantly higher (P = 0.019). In the operated group mean isokinetic muscle strength was 13.7 % lower than in the uninvolved leg and decreased significantly with non-operative treatment to 75.3 % (P = 0.012). We recommend surgical treatment of acute ATR. The indications for conservative treatment depend on the extent of the rupture (measured by ultrasound in the equinus position), the desired level of daily activity and the patient's degree of compliance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050223
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  • 9
    Electronic Resource
    Electronic Resource
    Microstructural Characterization and Structure/Property Relations of Microalloyed Medium Carbon Steels with Ferrite-Bainite/Martensite Microstructure (1998)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 284-286 (June 1998), p. 443-450 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/03/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.284-286.443.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Denitrification in the rooting zone of cropped soils with regard to methodology and climate: A review (1989)
    Springer
    Biology and fertility of soils 8 (1989), S. 219-226 
    Details
    ISSN: 1432-0789
    Keywords: Denitrification ; Acetylen inhibition technique ; 15N technique ; Organic residues ; Mineral fertilization ; Irrigation ; Temperate climate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Denitrification N losses can be determined by three methods. The first is by estimating the non-recovery of 15 N-labelled compounds (15N-balance method). Using this method, denitrification losses are deduced from the balance of an N budged (15N-labeled fertilizer), having accounted for transformations in soil, plant uptake, and leaching losses. The evolution of gaseous N from native soil N is not taken into account by this procedure. Studies on arable land with annual crops in the temperate zone have shown that of the fertilizer N applied, about 20–500% (10–70 kg N* ha−1) is not recovered at the end of the growth period. The second method of determining denitrification N losses is by in situ field measurement of 15 N 2 and 15 N 2 O production. Under this procedure, 15N-enriched N is applied to a plot and the denitrification N losses are determined by covering the soil. The method allows a quantitative estimate of the relative contributions to the emitted gas by both the original enriched source and the native soil N. N-evolution rates measured on arable land under a temperate climate are approximately the same order of magnitude as the N losses estimated by the non-recovery of 15 N method. The third measuring procedure is based on the acetylene inhibition phenomenon. This principle uses the inhibition of bacterial N2O reduction to N2 in the presence of acetylene (C2H2). The methoddetermines the denitrification of all NO3 −-N irrespective of its source. Measurements on classical crop production systems show maximum N losses in the temperate climate of about 20–30 kg N* ha−1 during the growth period of annual crops. A similar level of denitrification is estimated for grassland sites under the same climate. In the subtropics (mediterranean climate with hot summers and mild winters), from both intensively cultivated arable land and grassland sites, N losses may exceed 200 kg* ha−1 year−1. Without the use of irrigation the denitrification flux is negligible in spite of the high temperatures in this climate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266482
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