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  • Articles: DFG German National Licenses  (8)
  • 1995-1999  (7)
  • 1945-1949  (1)
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  • Articles: DFG German National Licenses  (8)
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  • 1
    Electronic Resource
    Electronic Resource
    Classical and quantum magnetism in synthetic ferritin proteins : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5324-5326 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The magnetic properties of nanometer-scale particles are studied using the protein-complex ferritin as a vesicle for either an antiferromagnet or a ferrimagnet. For antiferromagnetic ferritin particles, the anisotropy energy is found to depend linearly on the particle volume, suggesting that bulk anisotropy dominates over surface anisotropy. Effects due to the bulk and surface spins are discerned at high magnetic fields (27 T). At very low magnetic fields (1 nT) and temperatures (20 mK), the tunneling frequency of the Néel vector is observed to scale exponentially with the particle volume, consistent with the linear dependence of the anisotropy barrier on volume and with theories of macroscopic quantum coherence. In the ferrimagnetic particles, the anisotropy barrier decreases for smaller particles while simultaneously displaying a slight increase in coercivity and a dramatic decrease in the remanence over three orders of magnitude. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361366
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  • 2
    Electronic Resource
    Electronic Resource
    Early and late effects of low-dose famotidine, ranitidine or placebo on pentagastrin-stimulated gastric acid secretion in man (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: There are no published comparative studies on the effect of low-dose H2-antagonists on pentagastrin-stimulated gastric acid secretion. Methods: Twenty-four healthy subjects were dosed with either famotidine 10 mg, ranitidine 75 mg or placebo in a balanced three-period cross-over design. The subjects were studied in groups of 12, simultaneously, under identical controlled environmental conditions. Gastric juice was aspirated in 15-min aliquots during sub-maximal (0.6 μg . h/kg) intravenous pentagastrin stimulation in the third and fourth hours (early period) and the eighth and ninth hours (late period) after oral dosing. The hydrogen ion (H+) content of gastric juice was measured ex vivo, by titrating to pH 7 known volumes of gastric aspirate against 0.1 m sodium hydroxide, using a versatile microprocessor-controlled auto-titration unit. Gastric acid output during the period of interest was calculated by adding the hydrogen ion content of 15-min aliquots collected during that period. The geometric mean of the cumulative pentagastrin-stimulated gastric acid output during the early and late periods was determined for the subjects dosed with either famotidine, ranitidine or placebo. Comparisons were performed by ANOVA. Results: During the early period (2–4 h post-dose), when the subjects were given placebo, mean gastric acid output was 46.6 mmol, decreasing by 76% to 11.3 mmol (P〈0.001) when treated with famotidine and by 76% to 11.1 mmol (P〈0.001) when treated with ranitidine. During the late period (7–9 h post-dose), when the subjects were dosed with placebo, mean gastric acid output was 41.2 mmol, decreasing by 38% to 25.7 mmol (P〈0.001) when treated with famotidine and by 27% to 30.0 mmol (P=0.007) when treated with ranitidine. The difference between the inhibitory effects of famotidine and ranitidine on gastric acid output were non-significant during either period. Conclusions: Low-dose famotidine and ranitidine, intended for over-the-counter use, inhibit stimulated gastric acid secretion profoundly in the third and fourth hours after an oral dose. Modest effects are still detectable up to 9 h after dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.51193000.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Low-dose famotidine and ranitidine as single post-prandial doses: a three-period placebo-controlled comparative trial (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Low-dose H2-receptor antagonists are available without prescription for the self-medication of dyspepsia. Methods: To investigate the relative abilities of low doses of famotidine and ranitidine to raise intragastric pH after a single post-prandial evening dose, 25 healthy volunteers completed a three-period cross-over trial of famotidine 10 mg, ranitidine elixir 75 mg and placebo. A standard meal was given at 18.30 h and drug or placebo at 19.30 h to subjects fasted for 5.5 h. Intragastric pH was recorded with nasogastric electrodes from 18.00 to 07.30 h by GastrograpH II recorder. Results: The geometric mean area under the pH–time curve for the 5–9 h post-dose period was 1.49 pH units/h following placebo, 3.43 pH units/h following famotidine 10 mg (agent/placebo ratio 2.3; P〈 0.001, ANOVA) and 2.6 pH units/h following ranitidine 75 mg (1.75; P〈0.001). The geometric mean area under the pH–time curve ratio of famotidine 10 mg to ranitidine 75 mg was 1.32 (P〈0.016). Median pH over the 5–9 h period was 1.1 following placebo, 2.7 following famotidine 10 mg (P〈0.05 by comparison with placebo) and 1.9 following ranitidine 75 mg (P〈0.05); comparison of median pH showed no significant difference between the active drugs. The percentage of pH values greater than 3.0 for the period 0–12 h post-dose was 9.7% following placebo, 30.0% following famotidine 10 mg (P〈0.05) and 24.9% following ranitidine 75 mg (P〈0.05); there was no significant difference between the active drugs. Conclusions: We conclude that both famotidine 10 mg and ranitidine 75 mg significantly raise intragastric pH when given as single post-prandial doses. Famotidine 10 mg may have a greater effect than ranitidine elixir 75 mg over the 5–9-h period after dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.50192000.x
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  • 4
    Electronic Resource
    Electronic Resource
    Low dose famotidine in the prevention of sleep disturbance caused by heartburn after an evening meal (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 9 (1995), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To determine whether, in a susceptible opulation, dosing with 10 mg famotidine 1 h before an evening meal could decrease the interference with sleep caused by heartburn. Methods: Patients with a history of frequent heartburn (n= 309) were randomized to receive 10 mg famotidine or placebo 1 h before an evening meal likely to induce symptoms. Patients assessed the efficacy of the treatment in preventing heartburn after the meal, at bedtime and during the night. The number of awakenings due to heartburn and the consumption of antacid tablets taken to alleviate symptoms were also recorded. Results: Treatment groups were well matched and data from 302 patients were available for analysis. Compared to placebo, famotidine treated patients had: less heartburn after the meal (P 〈 0.0001 mean global scores), less interference with getting to sleep (P= 0.0156 mean global scores), fewer awakenings (P= 0.0001 difference in mean number) and better control of heartburn during the night (P 〈 0.0001 mean global scores). They were also almost three times less likely to need antacid treatment than the placebo group during the night (relative odds for no antacid 2.78 (95% CI: 1.29–5.96). Only four patients in each group suffered adverse events. Conclusion: Taking a 10 mg dose of famotidine 1 h before an evening meal appears to be a successful and well tolerated strategy for preventing post-prandial heartburn and avoiding the associated interference with sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1995.tb00397.x
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  • 5
    Electronic Resource
    Electronic Resource
    Nocturnal intragastric acidity after over-the-counter doses of famotidine, ranitidine or placebo (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To compare the inhibitory effects of over-the-counter doses of famotidine or ranitidine on nocturnal intragastric acidity in a placebo-controlled study.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Twelve-hour intragastric acidity was measured simultaneously in 24 healthy subjects who ate a standard meal at 18.30 h and were dosed (at 19.30 h) with either famotidine 10 mg, ranitidine 75 mg or placebo in a balanced three-period crossover design. Five-millilitre aliquots of gastric juice were aspirated half-hourly 0–3 h post-dose, and then hourly until the end of the study. pH was measured with a glass electrode. Integrated pH (area under the curve (AUC) of the pH–time curve) was calculated for the intervals 0–12 h and 9–12 h post-dose. Statistical analysis was by ANOVA.〈section xml:id="abs1-3"〉〈title type="main"〉Results:In the 0–12 h post-dose period, when the 24 subjects were dosed with placebo, mean AUC was 2.12, dosed increasing by 75% to 3.70 with famotidine (P 〈 0.001) and by 81% to 3.83 with ranitidine (P 〈 0.001). In the 9–12 h post-dose period, when the subjects were dosed with placebo, mean AUC was 2.13 increasing by 91% to 4.07 with famotidine (P 〈 0.001) and by 79% to 3.82 with ranitidine (P 〈 0.001). There was no significant difference between the pH-raising effects of famotidine and ranitidine in both periods.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:Famotidine and ranitidine in over-the-counter doses have a similar, sustained, effect on post-prandial nocturnal intragastric acidity in healthy subjects lasting up to 12 h after oral dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00211.x
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  • 6
    Electronic Resource
    Electronic Resource
    Prevention of heartburn relapse by low-dose famotidine: a test meal model for duration of symptom control (1997)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To establish whether patients taking famotidine 10 mg to treat an episode of heartburn were protected from a recurrence of symptoms after a subsequent test meal. Methods: Frequent heartburn sufferers (n=366) were randomized to receive double blind treatment with famotidine 10 mg or 2×250 mg chewable alginate tablets within 30 min of a spontaneous episode of heartburn. After 4 h, patients with no or slight residual symptoms consumed a meal likely to induce heartburn. Over the next 4 h patients recorded the severity of heartburn and any consumption of ‘rescue’ antacids. At the end of this time they rated the global efficacy of their treatment in controlling meal-induced symptoms. Results: Study groups were well matched for all baseline characteristics. Of the 366 randomized patients, 276 took study medication and data from 269 patients (132 famotidine, 137 alginate) were analysed for efficacy. Compared to the alginate control group famotidine treated patients reported better global efficacy following the test meal (P〈0.001; relative odds for a more favourable response: 2.26 [95% CI: 1.45–3.53]). Fewer patients receiving famotidine resorted to antacid rescue (P = 0.038; relative odds for a more favourable response: 2.24 [95% CI: 1.04–4.79]) and peak heartburn was significantly less severe with famotidine treatment (P〈0.001; relative odds for a more favourable response: 2.90 [95% CI: 1.85–4.53]). Eleven famotidine-treated patients (8%) and 13 alginate patients (9%) reported adverse events. Conclusion: Compared to patients receiving an alginate preparation, patients self medicating with famotidine 10 mg for heartburn are better protected against a recurrence of their symptoms when they next eat. This suggests that the duration of acid control (9 h) previously demonstrated with this dose translates into a similar duration of measurable symptom control during the day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.113284000.x
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  • 7
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    Unknown
    Jan Neruda - Poet and Essayist (1949)
    London, etc. : Periodicals Archive Online (PAO)
    Slavonic and East European review. 28 (1949/1950) 161 
    Details
    ISSN: 0037-6795
    Topics: History , Slavonic Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0072-1949-028-00-000012
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  • 8
    Electronic Resource
    Electronic Resource
    Zur Kenntnis der Alkalimetallthionylimide (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 621 (1995), S. 153-158 
    Details
    ISSN: 0044-2313
    Keywords: Alkali metal thionylimides ; preparation ; crystal structures ; IR-spectroscopy ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: On the Knowledge of the Alkali Metal ThionylimidesPreparation and properties of new alkali metal thionylimides MNSO (M = Na, Rb, Cs) and the known KNSO are reported. The characterization of the compounds was carried out by thermal analysis, IR-spectroscopy and X-ray powder diffraction. KNSO and RbNSO are isostructural (X-ray powder data): Pnma; KNSO: a = 766.81(2), b = 635.28(1), c = 704.22(2) pm; RbNSO: a = 800.21(1), b = 658.144(9), c = 731.39(1) pm. CsNSO (cubic; Pm3m; a = 464.78(3) pm) was described with a rotationally disordered [NSO]--anion. Force constants (GVFF-calculations) on the base of bond distances and bond angles of the anion were calculated.
    Notes: Es wird über die Darstellung und Charakterisierung neuer Alkalimetallthionylimide MNSO (M = Na, Rb, Cs) und des bekannten KNSO berichtet. Ihre Charakterisierung erfolgte mittels thermoanalytischer, IR-spektroskopischer und röntgenographischer Methoden. KNSO ist mit RbNSO isotyp (Röntgenpulverdaten): Pnma; KNSO: a = 766,81(2), b = 635,28(1), c = 704,22(2) pm; RbNSO: a = 800,21(1), b = 658,144(9), c = 731,39(1) pm. Für CsNSO (kubisch; Pm3m; a = 464,78(3) pm) wurde unter Annahme eines rotationsfehlgeordneten [NSO]--Anions ein Strukturmodell entwickelt. Auf Grundlage der Bindungsabstände und -winkel des Anions wurden GVFF-Kraftkonstantenrechnungen durchgeführt.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19956210128
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