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  • Articles: DFG German National Licenses  (2)
  • 1995-1999  (2)
  • Disseminated intravascular coagulation  (1)
  • Amoeba-approach
  • Pulmonary circulation
  • objectives
  • water management
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    The influence of antithrombin III (AT III) substitution to supranormal activities on systemic procoagulant turnover in patients with end-stage chronic liver disease (1997)
    Springer
    Intensive care medicine 23 (1997), S. 1150-1158 
    Details
    ISSN: 1432-1238
    Keywords: Key words Antithrombin III ; Coagulation ; Disseminated intravascular coagulation ; Disseminated intravascular coagulation ; Liver failure ; Liver cirrhosis ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Since antithrombin III (AT III) substitution to normal activities could not be shown to have major beneficial effects in patients with end-stage chronic liver disease in a variety of clinical settings, we tested the hypothesis that substitution to supranormal activities decreases systemic procoagulant turnover better in this patient group. Design: Controlled prospective clinical study. Setting: Operating rooms at a University Hospital. Patients: Twenty-four patients with histologically verified liver cirrhosis consecutively scheduled for liver transplantation. Interventions: Nineteen patients were given an antithrombin III concentrate to achieve either 100 % (n = 10) or 175 % (n = 9) AT III activity. Control patients (n = 5) received saline 0.9 % instead. Measurements and results: Molecular markers of coagulation activation, platelet count and aggregability, and global coagulation variables were measured prior to AT III infusion and 60 min thereafter. In both AT III-treated groups thrombin-antithrombin III-complex increased significantly (p 〈 0.005), whereas prothrombin fragment F1 + 2, soluble fibrin and D-dimer concentrations, as well as other variables, did not show major changes. Conclusions: Despite thrombin inhibition by AT III in patients with end-stage chronic liver disease, systemic procoagulant turnover was not significantly decreased 60 min after AT III application even to supranormal activities. Replenishment of the inhibitory antithrombin III pool, decreased in chronic liver disease, should not be expected to slow down the baseline consumptive component of the haemostatic disorder in this patient group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050472
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Interaction between haematocrit and pulmonary blood volume on pulmonary vascular flow resistance and pressure-flow relationships (1997)
    Springer
    Intensive care medicine 23 (1997), S. 1082-1088 
    Details
    ISSN: 1432-1238
    Keywords: Key words Haemoconcentration ; Haemodilution ; Pressure-flow relationship ; Pulmonary circulation ; Pulmonary vascular flow resistance ; Pulmonary vascular hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Pulmonary vascular flow resistance depends on blood viscosity, mainly due to haematocrit, and on vessel dimensions determining blood volume in this highly compliant vascular bed. We, therefore, evaluated the interaction between haematocrit, blood flow, and transpulmonary vascular pressure gradient under conditions of controlled pulmonary blood volume. Design: Experimental study in isolated zone-III rabbit lungs perfused with autologous blood. Setting: Laboratory for experimental studies. Interventions: Stepwise and independent variation of flow (50, 100, and 200 ml/min), pulmonary blood volume (increments of 2.5 ml and 5 ml imposed by changes of left atrial pressure), and haematocrit (0–50 %) varied by haemodilution (Krebs-Henseleit/albumin) or haemoconcentration (centrifugation). Measurements: Pulmonary arterial, left atrial, and airway pressures as well as reservoir volume (reflecting reciprocal changes of lung blood volume) and lung weight. Results: Haemodilution from the normal haematocrit (32 %) to 10 % at constant pulmonary blood volume and flow decreased flow resistance only slightly, whereas haemoconcentration (50 %) increased flow resistance up to 130 %. At the same time increments of in pulmonary blood volume of 2.5 and 5 ml (approx. 15 and 30 % of normal pulmonary blood volume) at constant haematocrit significantly shifted downwards pressure-flow relationships for all investigated haematocrits (0–50 %). Conclusions: Because of the multiple interrelationships between haematocrit, blood flow and pulmonary blood volume, haematocrit effects on pulmonary flow resistance and pressure-flow relationships in the pulmonary vasculature should be studied at controlled blood volume. While haemodilution only has minor effects, haemoconcentration changes pressure-flow relationships markedly. Pulmonary blood volume has a major impact on slope and position of pressure-flow relationships for all haematocrits investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050460
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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