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  • Articles: DFG German National Licenses  (2)
  • 1995-1999  (2)
  • Key words Hypoxia  (2)
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  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1995-1999  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Biochemical and immunological changes on oral glutamate feeding in male albino rats (1999)
    Springer
    International journal of biometeorology 42 (1999), S. 201-204 
    Details
    ISSN: 1432-1254
    Keywords: Key words Hypoxia ; Metabolic stress ; Immunity ; Glutamate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract  High altitude stress leads to lipid peroxidation and free radical formation which results in cell membrane damage in organs and tissues, and associated mountain diseases. This paper discusses the changes in biochemical parameters and antibody response on feeding glutamate to male albino Sprague Dawley rats under hypoxic stress. Exposure of rats to simulated hypoxia at 7576 m, for 6 h daily for 5 consecutive days, in an animal decompression chamber at 32±2° C resulted in an increase in plasma malondialdehyde level with a concomitant decrease in blood glutathione (reduced) level. Supplementation of glutamate orally at an optimal dose (27 mg/kg body weight) in male albino rats under hypoxia enhanced glutathione level and decreased malondialdehyde concentration significantly. Glutamate feeding improved total plasma protein and glucose levels under hypoxia. The activities of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) and the urea level remained elevated on glutamate supplementation under hypoxia. Glutamate supplementation increased the humoral response against sheep red blood cells (antibody titre). These results indicate a possible utility of glutamate in the amelioration of hypoxia-induced oxidative stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004840050105
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of hypobaric hypoxia on immune function in albino rats (1998)
    Springer
    International journal of biometeorology 42 (1998), S. 55-59 
    Details
    ISSN: 1432-1254
    Keywords: Key words Hypoxia ; Macrophage activation ; Oxidative stress ; Immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract  The effect of exposure to hypoxia on macrophage activity, lymphocyte function and oxidative stress was investigated. Hypoxia enhanced peritoneal macrophage activity as revealed by enhanced phagocytosis and free radical production. There was no significant change in antibody titres to sheep red blood cells in either serum or spleen during hypoxia. However, there was a considerable reduction in the delayed-type hypersensitivity response to sheep red blood cells, indicating the impairment of T-cell activity. Hypoxia decreased the blood glutathione (reduced) level and increased plasma malondialdehyde by a factor of about 2. It is therefore speculated that hypoxia imposes an oxidative stress leading to decreased T-cell acivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004840050084
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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