Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (2)
  • 1990-1994  (2)
  • 1940-1944
  • 73 K 10  (1)
  • Antisense  (1)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1990-1994  (2)
  • 1940-1944
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 72 (1994), S. 737-741 
    ISSN: 1432-1440
    Keywords: Hepatitis B ; Antiviral agents ; Oligonucleotides ; Antisense
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic infection with the hepatitis B virus is a major health problem worldwide. The only established therapy is interferon-α, with an efficacy of only 30–40% in highly selected patients. Nucleoside analogues do not show a significant clinical benefit. Molecular therapeutic strategies aimed at blocking gene expression include antisense DNA/RNA and ribozymes acting at the posttranscriptional level and triple helix formation blocking at the transcriptional level. In vitro, antisense oligodeoxynucleotides inhibit viral replication and gene expression in human hepatoma cell lines. In vivo, an antisense oligodeoxynucleotide directed against the 5′-region of the pre-S gene of the duck hepatitis B virus inhibited viral replication and gene expression in ducks. In vitro, ribozymes accurately cleave HBV substrate RNA. Triple helix formation is another very promising molecular approach. Results in hepadnaviral infection are not yet available, however.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 6 (1990), S. 221-236 
    ISSN: 1432-0924
    Keywords: 65 N 30 ; 73 K 10 ; 73 K 25
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary Most of the existing convergence theory of mixed finite element methods for solving the plate bending problem converns the model case of a purely clamped or simply supported plate with sufficiently regular boundary. The extension of this analysis to more complicated situations encounters two major difficulties: first, the problem of verifying the stability of the schemes in the case of a partially free boundary and, second, the reduction of the solution's regularity in the presence of reentrant corners or changes in the type of the boundary conditions. In this paper these questions are studied for the approximation of the Kirchhoff plate model by one of the mixed finite element schemes due to L. R. Herrmann, the so-called “first Herrmann scheme”. It is shown that this method converges on any polygonal domain and for all usual boundary conditions. The proof is based on the fact that this particular mixed scheme is algebraically equivalent to a nonconforming displacement method.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...