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  • 1
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 799-799 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732190
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  • 2
    Electronic Resource
    Electronic Resource
    Solid-phase radioimmunoassay for hepatitis be antigen (HBeAg) (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 1129-1132 
    Details
    ISSN: 1432-1440
    Keywords: Hepatitis B ; HBsAg ; HBeAg ; Anti-HBe ; Solid-Phase Radioimmunoassay ; Hepatitis B ; HBsAg ; HBeAg ; anti-HBe ; Solid-Phase Radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A solid-phase radioimmunoassay was developed for the detection of HBeAg and anti-HBe in sera or serum fractions. HBe/sAg positive sera, partially purified HBeAg, partially purified HBsAg, and HBe/sAg negative sera were polymerized in polyacrylamide and compared for their ability to bind125I-IgG (anti-HBe). Only gels containing HBeAg reacted specifically with the iodinated antibody. The specificity of the binding was confirmed by blocking and inhibition tests using anti-HBe, HBeAg, HBsAg, and negative control sera. The radioimmunoassay allows the specific and quantitative detection of HBeAg and anti-HBe even in the presence of detergents and high salt concentrations.
    Notes: Zusammenfassung Ein Radioimmunoassay wurde entwickelt zum Nachweis von HBeAg und anti-HBe in Serum oder Serumfraktionen. HBe/sAg positives Serum, teilweise gereinigtes HBeAg, teilweise gereinigtes HBsAg und HBe/sAg negatives Kontrollserum wurden in Polyacrylamid polymerisiert und auf ihre Bindungsfähigkeit für125I-IgG (anti-HBe) untersucht. Nur Gele mit immobilisiertem HBeAg reagierten spezifisch mit anti-HBe. Die Spezifität der Bindung wurde gesichert durch Blockierungs-/Inhibitionsteste mit anti-HBe, HBeAg, HBsAg und negativen Kontrollseren. Der Radioimmunoassay ermöglicht den spezifischen und quantitativen Nachweis von HBeAg und anti-HBe, auch in Gegenwart von Detergentien und hohen Salzkonzentrationen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01481494
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular therapeutic strategies in hepatitis B virus infection (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 737-741 
    Details
    ISSN: 1432-1440
    Keywords: Hepatitis B ; Antiviral agents ; Oligonucleotides ; Antisense
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic infection with the hepatitis B virus is a major health problem worldwide. The only established therapy is interferon-α, with an efficacy of only 30–40% in highly selected patients. Nucleoside analogues do not show a significant clinical benefit. Molecular therapeutic strategies aimed at blocking gene expression include antisense DNA/RNA and ribozymes acting at the posttranscriptional level and triple helix formation blocking at the transcriptional level. In vitro, antisense oligodeoxynucleotides inhibit viral replication and gene expression in human hepatoma cell lines. In vivo, an antisense oligodeoxynucleotide directed against the 5′-region of the pre-S gene of the duck hepatitis B virus inhibited viral replication and gene expression in ducks. In vitro, ribozymes accurately cleave HBV substrate RNA. Triple helix formation is another very promising molecular approach. Results in hepadnaviral infection are not yet available, however.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180539
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  • 4
    Electronic Resource
    Electronic Resource
    Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 466-472 
    Details
    ISSN: 1432-1335
    Keywords: Hepatitis B virus ; Hepatocellular carcinoma ; Hepatocarcinogenesis ; viral oncogenesis ; Molecular hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clonality of tumor cells was studied in a patient with metastasizing hepatocellular carcinoma (HCC). Using hepatitis B virus (HBV) DNA as a genetic marker, the pattern of integration of viral DNA into the tumor cell genome was determined by Southern blot analyses of DNAs extracted from different HCC lesions in the liver and both lungs. All tumor tissues examined were found to have viral DNA integrated into the same site(s) of the cellular genome. This finding provides direct molecular evidence for a monoclonal origin and expansion of malignantly transformed hepatocytes during tumor growth and metastasis. This characteristic is similar to other human cancers associated with viral infections, such as adult T-cell leukemia, Burkitt's lymphoma, or cervical cancer, and is important für our understanding of viral oncogenesis in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390041
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  • 5
    Electronic Resource
    Electronic Resource
    Neurological manifestations of chronic hepatitis C (1999)
    Springer
    Journal of neurology 246 (1999), S. 486-491 
    Details
    ISSN: 1432-1459
    Keywords: Key words Hepatitis C virus ; infection ; Vasculitic neuropathy ; Cerebral vasculitis ; Autoimmune ; response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatitis C virus (HCV) infection is often associated with abnormal immunological responses. We describe four patients with vasculitic neurological signs and symptoms following HCV infection. A 56-year-old woman with HCV infection developed peripheral neuropathy characterized by asymmetric distal painful hypesthesia, dysesthesia and moderate motor weakness of the lower limbs. Serological examinations revealed cryoglobulinemia and low levels of complement C4. A biopsy of the sural nerve revealed vasculitic neuropathy. HCV infection associated immunomediated vasculitis was diagnosed. While steroid therapy was ineffective, treatment with interferon-α improved the neuropathy considerably without, however, eliminating HCV infection. A 62-year-old man with HCV infection developed peripheral sensory neuropathy. Complement C3 was slightly diminished. Nerve biopsy revealed vasculitic neuropathy. A 71-year-old woman developed chronic symmetric sensomotor polyneuropathy. HCV hepatitis followed blood transfusions. Cryoglobulins tested positive, consistent with type II cryoglobulinemia. Complements C3 and C4 were diminished. Inflammatory infiltrates in the sural nerve biopsy specimen led to the diagnosis of chronic vasculitic disorder. A 55-year-old woman with HCV infection developed vasculitis of the skin, connective tissue, visceral organs, and kidney, leading to hemodialysis. Neurologically she developed severe apathy and drowsiness, myoclonic jerks, exaggerated deep tendon reflexes, and positive pyramidal signs. Magnetic resonance imaging of the brain showed diffuse increased signal abnormalities involving supra- and infratentorial white matter suggesting cerebral vasculitis. Cryoglobulins were positive, complements C3 and C4 slightly diminished (54 mg/dl, 4.3 mg/dl). Supportive therapy resulted in neurological improvement. Treatment with interferon-α was discontinued because of agranulocytosis. In patients with peripheral neuropathy or signs of leucencephalopathy, a hepatitis C associated vasculitis should be considered in the differential diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050388
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  • 6
    Electronic Resource
    Electronic Resource
    Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten (1991)
    Springer
    Naturwissenschaften 78 (1991), S. 241-249 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01134350
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  • 7
    Electronic Resource
    Electronic Resource
    Der Patient mit Hepatopathie (1997)
    Springer
    Der Chirurg 68 (1997), S. 763-769 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Surgery ; Anesthesia ; Analgesia ; Liver diseases ; Hepatic dysfunction ; Hepatotoxins. ; Schlüsselwörter: Chirurgie ; Anaesthesie ; Analgesie ; Lebererkrankungen ; Leberinsuffizienz ; Hepatotoxine.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Erhöhte „Leberwerte“ sind ein häufiges klinisches Problem von unterschiedlicher Signifikanz. Die Entscheidung über die Indikation zur weiteren hepatologischen Abklärung ist im Kontext der klinischen Präsentation und Fragestellung zu sehen. Präoperativ erhöhte „Leberwerte“ sind bei Elektivoperationen Indikation zur weiteren Abklärung und ggf. Therapie. Symptomatische Patienten mit Hepatopathie haben ein erhöhtes Operationsrisiko. Zur Reduktion der erhöhten Morbidität und Letalität von Patienten mit akuter oder chronischer Hepatopathie ist ein Verständnis der pathophysiologischen Zusammenhänge für die optimale prä-, intra- und postoperative Betreuung von großer klinischer Relevanz.
    Notes: Summary. Elevated liver enzymes are a frequent clinical finding. Their significance depends on the clinical presentation and setting. Symptomatic patients with acute or chronic liver disease carry an increased surgical risk. To reduce the morbidity and mortality associated with symptomatic liver diseases the understanding of the pathophysiology of liver dysfunctions is of paramount importance for the pre-, intra- and postoperative management of such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050267
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  • 8
    Electronic Resource
    Electronic Resource
    Orthotopic liver transplantation in hemophilia B: a case report (1995)
    Springer
    Transplant international 8 (1995), S. 485-487 
    Details
    ISSN: 1432-2277
    Keywords: Hemophilia B, liver transplantation ; Liver transplantation, hemophilia B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Liver transplantation is a treatment modality that is being used with increasing frequency in cases of liver-based metabolic defects. This is a case report of a patient with hemophilia B who was treated since childhood with factor IX replacement for recurrent hemarthroses. Subsequent hepatitis B (HBV) and C (HCV) infection had resulted in the development of chronic active hepatitis, ultimately leading to cirrhosis. Orthotopic liver transplantation performed for endstage liver disease resulted in a rise in factor IX levels from 2% to 83% of normal values within 24 h post-operatively, and levels remained above 90% of normal values after postoperative day 3 without factor IX replacement. To our knowledge, only two cases of hemophilia B treated by orthotopic liver transplantation have been reported. This procedure has, however, only been implemented in cases of terminal liver insufficiency in hemophiliacs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335602
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  • 9
    Electronic Resource
    Electronic Resource
    Risk Factors and Prevention of Early Infection After Implantation or Revision of Transjugular Intrahepatic Portosystemic Shunts (Results of a Randomized Study) (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1708-1713 
    Details
    ISSN: 1573-2568
    Keywords: LIVER CIRRHOSIS ; TIPS ; INFECTION ; PREVENTION ; PORTASYSTEMIC SHUNT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to evaluate theefficacy of a single dose of a second-generationcephalosporine to prevent postinterventional infectionand to identify risk factors for postinterventionalinfection in patients receiving implantation or revisionof a transjugular intrahepatic portosystemic shunt(TIPS). Eighty-four patients (105 transjugularinterventions) were randomized receiving no antibiotictreatment (46 interventions) or 2 g cefotiam (56interventions) given at the beginning of the procedure.Patients with overt infection or those receivingantibiotic treatment in the preceding two weeks wereexcluded. Groups were comparable with respect tobiographic and medical data. Postinterventionalinfection was defined as an increase in WBC count(≥15,000/μl), fever (38.5°C), or a positiveblood culture. Infection occurred in 17% of the patients. Patients notreceiving cefotiam had a slightly higher incidence ofinfection (20%) than patients treated with cefotiam(14%, NS). Multivariate analysis demonstrated prognostic relevance for multiple stenting andperiprocedural use of a central venous line. Theclinical outcome of the patients was unaffected bycefotiam treatment. In conclusion, a single dose ofintrainterventional cefotiam does not prevent postinterventionalinfection. This may be due to the antimicrobial spectrumand short half-time of cefotiam. Strict adherence toaseptic conditions during intervention and early removal of central venous lines may reduce therate of post interventional infection considerably.Antibiotic prophylaxis with cefotiam does not seem to beuseful since it will not influence outcome andcosts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018819316633
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