ISSN:
1434-0879
Keywords:
Aging
;
Atrophy
;
External urethral sphincter
;
Female rabbit
;
Myosin heavy chain
;
SDS-PAGE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The proportions of fast and slow myosin molecules in specimen's of the external urethral sphincter (EUS) from 6 young nulliparous (6-month-old) and 6 old multiparous (2-year-old) rabbits were studied using myosin heavy chain electrophoresis. The percentages of fast and slow myosin molecules were 80.4±4.5% and 19.6±4.5% in the EUS from nulliparas, and 68.7±6.3% and 31.3±6.3% in the EUS from multiparas. The difference between the two groups was significant (P〈0.01). We suggest that a selective decrease in the volume of type 2 (fast) muscle fibers and/or conversion of type 2 to type 1 (slow) muscle fibers had taken place in the EUS of old multiparas. The proportional change in the constitutent muscle fibers of the EUS with aging may play a role in human genuine stress incontinence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01788830
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