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  • Articles: DFG German National Licenses  (3)
  • 1990-1994  (3)
  • Amyotrophic lateral sclerosis  (2)
  • Bone mineral density  (1)
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  • Articles: DFG German National Licenses  (3)
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Clarke's column in sporadic amyotrophic lateral sclerosis (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 465-470 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Clarke's column ; Bunina body ; Spheroid ; neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7 of the 12 non-respirator-supported ALS patients and in 3 of the 6 respirator-supported patients. The number of spheroids was significantly higher in the non-respirator-supported patients (P〈0.01) than in the control subjects; however, the number in the respirator-supported patients was about equal to that in the controls. The number of neurons in Clarke's column in the non-respirator-supported ALS patients was not reduced, but in the respirator-supported patients they tended to disappear with time after respiratory support. These findings suggest that Clarke's column neurons are also involved primarily in the disease process in sporadic ALS. However, they may begin to disappear only after the patients require respiratory support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304464
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The intermediolateral nucleus in sporadic amyotrophic lateral sclerosis (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 190-192 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Intermediolateral nucleus ; Quantitative examination ; Bunina body ; Neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological and morphometrical observations of the intermediolateral nucleus (IML) at the levels of the upper and lower thoracic segments (T2 and T9) were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. No Bunina bodies were found in the IML neurons in either the ALS patients or the control subjects. Only a small number of spheroids were encountered rarely in the IML in both the patients and controls. The number of neurons in the IML in the non-respirator-supported ALS patients were reduced at T2, but well preserved at T9 compared with the control subjects. In the respirator-supported ALS patients, there was a marked reduction of IML neurons at both T2 and T9. Considering the absence of direct synaptic contacts with anterior horn cells, these neurons, without the formation of Bunina bodies, appeared to be involved primarily in the disease process in sporadic ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334889
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bone mineral density and bone histomorphometric assessments of postpregnancy osteoporosis: A report of five patients (1994)
    Springer
    Calcified tissue international 54 (1994), S. 20-25 
    Details
    ISSN: 1432-0827
    Keywords: Idiopathic osteoporosis ; Pregnancy ; Lactation ; Bone mineral density ; Bone histomorphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Reports of five young women who developed vertebral fractures associated with pregnancy and lactation are presented (Fig. 1). Ages ranged from 24 to 37 (mean 30) years. All five patients have osteoporosis with two to nine vertebral fractures at presentation postpartum. Bone mineral density (BMD) was measured by single-photon absorptiometry, quantitative computer tomography, and dual-energy X-ray absorptiometry. BMD of the trabecular bone was less than normal values and it remained apparently low even several years after pregnancy. Histological findings of bone biopsy identified the bone loss with increasing bone resorption. Our present findings suggest that postpregnancy osteoporosis affects mainly the trabecular bone site, and the patients might have low peak bone mass and poor reversibility probably due to a low rate of remodeling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316284
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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