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Digitale Medien

Pharmacokinetics of 11C-BCNU in experimental brain tumor (1985)

Sako, Kazuhiro ; Diksic, Mirko ; Farrokhzad, Simin ; [weitere]

Springer

Journal of neuro-oncology 3 (1985), S. 229-235

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Details

ISSN: 1573-7373

Schlagwort(e): 11C-BCNU ; in vivo decomposition ; rat brain tumor model

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Wistar rats implanted intracerebrally with AA ascites tumor were injected seven or eight days later with 11C-labelled BCNU. Radioactive compounds in samples of plasma, tumor, and contralateral brain were identified after injection at intervals by doing chloroform extraction and thin layer radiochromatography. At 60 min after injection radioactivity levels were 56% higher in the tumor than in contralateral brain. This increase was due mainly to 2-chloroethyl isocyanate, which binds to amino groups and/ or nucleic acid. The results demonstrated both a higher concentration and a faster decomposition of BCNU in the tumor.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00165183

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