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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Acute Fluoxetine Treatment on the Brain Serotonin Synthesis as Measured by the α-Methyl-l-Tryptophan Autoradiographic Method (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of treatment with acute fluoxetine, a serotonin reuptake inhibitor, on the rate of serotonin synthesis in the rat brain was studied through autoradiography following intravenous administration of α-methyl-l-[3H]tryptophan. The rate of serotonin synthesis in fluoxetine-treated rats was compared with the rate measured in sham-treated rats (saline injection). Results showed a significant increase in the rate of synthesis in the majority of cerebral structures examined. The greatest increase (given as a percentage of rates in control animals) in the rate of serotonin synthesis was observed in the substantia nigra compacta (344%), hippocampus-CA3 (337%), dorsal hippocampus (283%), and caudate-putamen (232%). Fluoxetine had a less significant effect on the rate of synthesis in the pineal body (44%). Data suggest that acute fluoxetine treatment (30 mg/kg, i.p.) enhances the rate of serotonin synthesis in all the structures of rat brain examined in this work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65010250.x
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  • 2
    Electronic Resource
    Electronic Resource
    Improved synthesis and low-temperature autoradiographic evaluation of 18F-n-fluoropropane as a myelin tracer for positron emission tomography (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 553-557 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An improved synthesis of the lipophile 18F-fluoropropane, yielding 30–45 mCi 18F-labelled radiopharmaceutical, is described. The radiochemical yield was 55%–66% determined at the end of a 1-h synthesis. Radiochemical and chemical purity of 18F-fluoropropane was 99% as determined by gas chromatography. Low-temperature autoradiography was used to investigate the lipophile 18F-n-fluoropropane as a myelin tracer for use with positron emission tomography. The white to grey matter ratio based on autoradiograms 12 min after administration of the radiotracer was 2:1, the highest reported to date.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256855
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  • 3
    Electronic Resource
    Electronic Resource
    Regional glucose utilization and blood flow in experimental brain tumors studied by double tracer autoradiography (1985)
    Springer
    Journal of neuro-oncology 3 (1985), S. 271-283 
    Details
    ISSN: 1573-7373
    Keywords: double tracer autoradiogram ; regional glucose utilization ; regional blood flow ; implanted brain tumor model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Coupling of regional glucose utilizatio (GLU) and blood flow (CBF) was examined in rats with implanted brain tumors (AA ascites tumor) by quantitative double tracer autoradiography using 18F-2-fluorodeoxyglucose and 14C-iodoantipyrine. Four to 13 days after implantation, the animals were injected with the two tracers to obtain autoradiograms from the same brain section before and after the decay of 18F. The autoradiograms were then analyzed by an image processor to obtain a metabolic coupling index (MCI = GLU/ CBF). In the tumor, high GLU and low CBF were uncoupled to give a high MCI which implied anerobic glycolysis. In large tumors, the CBF was even lower. In the peri-tumoral region, GLU was reduced (especially in gray matter) and reduction was lowest around the larger tumors. CBF in the peri-tumoral region was also reduced, but this reduction became less as the distance from the tumor margin increased. These changes in the peri-tumoral region may be secondary to edema. The GLU and CBF of white matter was little influenced by the presence of tumors except for some reduction in these values in relation to the larger tumors. On a narrow margin of tumor and brain, corresponding to a zone of increased vascularity, CBF was moderately high. The MCI in the tumor was higher than in the cortex of the same as well as the opposite hemisphere. These findings indicate that the metabolism and blood flow of the tumor and surrounding brain are variable and directly related to tumor size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165189
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  • 4
    Electronic Resource
    Electronic Resource
    Positron emission tomography (1984)
    Springer
    Neurosurgical review 7 (1984), S. 233-252 
    Details
    ISSN: 1437-2320
    Keywords: Clinical application ; imaging techniques ; methodology ; positron emission tomography ; radiochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One of the most exciting new techniques introduced in the last ten years is positron emission tomography (PET). PET provides quantitative, three-dimensional images for the study of specific biochemical and physiological processes in the human body. This approach is analogous to quantitativein vivo autoradiography but has the added advantage of permitting non-invasivein vivo studies. PET scanning requires a small cyclotron to produce short-lived positron emitting isotopes such as oxygen-15, carbon-11, nitrogen-13 and fluorine-18. Proper radiochemical facilities and advanced computer equipment are also needed. Most important, PET requires a multidisciplinary scientific team of physicists, radiochemists, mathematicians, biochemists and physicians. This review analyses the most recent trends in imaging technology, radiochemistry, methodology, and clinical applications of positron emission tomography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01892905
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 11C-BCNU in experimental brain tumor (1985)
    Springer
    Journal of neuro-oncology 3 (1985), S. 229-235 
    Details
    ISSN: 1573-7373
    Keywords: 11C-BCNU ; in vivo decomposition ; rat brain tumor model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wistar rats implanted intracerebrally with AA ascites tumor were injected seven or eight days later with 11C-labelled BCNU. Radioactive compounds in samples of plasma, tumor, and contralateral brain were identified after injection at intervals by doing chloroform extraction and thin layer radiochromatography. At 60 min after injection radioactivity levels were 56% higher in the tumor than in contralateral brain. This increase was due mainly to 2-chloroethyl isocyanate, which binds to amino groups and/ or nucleic acid. The results demonstrated both a higher concentration and a faster decomposition of BCNU in the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165183
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  • 6
    Electronic Resource
    Electronic Resource
    Permeability change and brain tissue damage after intracarotid administration of cisplatin studied by double-tracer autoradiography in rats (1995)
    Springer
    Journal of neuro-oncology 24 (1995), S. 229-240 
    Details
    ISSN: 1573-7373
    Keywords: cisplatin ; intracarotid chemotherapy ; multi-tracer autoradiography ; blood brain barrier ; cerebral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was designed to find the reliable parameter(s) for the detection of early neurotoxicity following intracarotid (IC) administration of cisplatin. IC administration was performed for 60 minutes in female Wistar rats derived into four groups according to the dose given (1 mg, 1.2 mg, and 1.5 mg of cisplatin, and normal saline in control rats). Blood-brain barrier (BBB) permeability and local cerebral blood flow (LCBF) were measured by a double-tracer autoradiography technique using 1-[14 C]-α-aminoisobutyric acid (14 C-AIB) and 4-[18 F] fluoroantipyrine (18 F-FAP), respectively. Blood chemistry and neuropathology were also examined. BBB permeability was incereased only on the ipsilateral side. This increase was dose-dependent, preceded the brain necrosis, and was statistically significant in the hypothalamus [1.2 mg group), auditory cortex and caudoputamen (1.5 mg group). Renal dysfunction was often observed. The changes in the LCBF did not occur until brain necrosis was noticeable. These findings demonstrate that the increase in the BBB permeability provides a sensitive and reliable indication of an early toxicity to brain tissue following IC administration of cisplatin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052839
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