Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
328 (1985), S. 368-372
ISSN:
1432-1912
Keywords:
Ventrolateral medulla
;
Spinal transection
;
Pressor response
;
Glutamate
;
Kainic acid
;
Vasopressin antagonist
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We localized glutamate-sensitive sites in the ventrolateral medulla of the rat with the spinal cord cut at C1. When unilaterally injected into a circumscribed region of the caudal ventrolateral medulla,l-glutamate (30–300 ng) elicited a dose-dependent increase in arterial pressure. The pressor response was accounted for by an increased release of vasopressin because it was abolished by the intravenous injection of a vasopressin antagonist. Bilateral microinjections of kainic acid (50 ng) into the ventrolateral glutamate-sensitive area markedly reduced a vasopressin-induced pressor response to kainic acid (30 ng), injected bilaterally into the nucleus tractus solitarii. It is concluded that the glutamate-sensitive neurons in the caudal ventrolateral medulla are involved in mediation of the vasopressin-induced pressor response arising from the nucleus tractus solitarii.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00692902
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