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  • Articles: DFG German National Licenses  (12)
  • 1980-1984  (6)
  • 1965-1969  (6)
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  • Articles: DFG German National Licenses  (12)
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Keywords
  • 1
    facet.materialart.
    Unknown
    Zur Spezifik der Sprache des Ingenieurs und des ingenieurmässigen Gestaltens (1984)
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 32:5 (1984) 479 
    Details
    ISSN: 0012-1045
    Topics: Philosophy
    Description / Table of Contents: ZUM VI. PHILOSOPHIE-KONGRESS DER DDR
    Notes: BEMERKUNGEN UND BERICHTE
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1984-032-05-000013
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic variability of soluble proteins studied by two-dimensional electrophoresis on different inbred mouse strains and on different mouse organs (1982)
    Springer
    Journal of molecular evolution 18 (1982), S. 315-328 
    Details
    ISSN: 1432-1432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The soluble proteins of four organs (liver, kidney, brain and muscle) of mice from four inbred strains (C57BL/6J, DBA/2J, AKR/J and BALB/cHan) and offspring from cross-breedings therefrom are investigated for genetic variants. The female mice from each strain are divided into different groups according to age (12–14 and 24–26 weeks) and generation (P and F1). The proteins are separated by two-dimensional gel electrophoresis (2DE) using two different techniques (2D GE and 2D SDS-GE), developed in our laboratory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733898
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  • 3
    Electronic Resource
    Electronic Resource
    Cri-du-chat-Syndrom mit Translokation 5/D2 (1966)
    Springer
    Human genetics 〈Berlin〉 2 (1966), S. 63-77 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285911
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  • 4
    Electronic Resource
    Electronic Resource
    Polyploidization in the fish family Cyprinidae, order Cypriniformes (1969)
    Springer
    Human genetics 〈Berlin〉 7 (1969), S. 245-250 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the fish family Cyprinidae, a diploid-tetraploid relationship exists among the various members examined as shown by chromosome analysis and measurements of the DNA content per cell. Duplications of individual gene loci in the tetraploids are demonstrated using the LDH- and 6-PGD-isoenzyme systems as gene markers, thus confirming the hypothesis of polyploidization. In some diploids endowed with an increased DNA content per cell, a duplication is demonstrable for the 6-PGD cistrons only, and not for the LDH cistrons, thus supporting the hypothesis that regionally confined duplications have occured independently of polyploidization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273174
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  • 5
    Electronic Resource
    Electronic Resource
    Duplication of the LDH gene loci by polyploidization in the fish order Clupeiformes (1968)
    Springer
    Human genetics 〈Berlin〉 5 (1968), S. 190-196 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Within the order Clupeiformes, chromosome analysis and DNA measurements have indicated a diploid-tetraploid relationship among closely related species. To confirm the presence of polyploidization at single gene loci we studied the LDH isoenzyme system. The results obtained are in agreement with the hypothesis of polyploidization. While the diploid species show two gene loci for LDH, the tetraploid species exhibit four separate gene loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281954
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  • 6
    Electronic Resource
    Electronic Resource
    Two-dimensional electrophoresis of soluble and structure-bound proteins from cultured human fibroblasts and hair root cells: Qualitative and quantitative variation (1983)
    Springer
    Human genetics 〈Berlin〉 63 (1983), S. 262-267 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Proteins from cultured human fibroblasts and native human hair root cells were investigated using the twodimensional electrophoresis (2DE) technique. Cell material from 35 different healthy persons was examined. Proteins of different sources were separated: total proteins of fibroblasts (12 cell lines), soluble proteins of fibroblasts (12 cell lines), structurebound proteins of fibroblasts (eight cell lines) and soluble proteins of hair root cells (12 subjects). The protein samples of different individuals were run in pairs through the electrophoresis procedure and the two patterns of each pair were compared. All changes in the electrophoretic mobility of polypeptide spots (qualitative variants) and all clearly visible differences in the staining intensity of the spots (quantitative variants) were scored. Less than 1% of the qualitative variants per pattern was found in total cell proteins and this percentage was not increased in soluble proteins. No qualitative variation was detected in structure-bound proteins. Quantitative variation occurred to a considerably higher degree in the 2DE patterns than qualitative changes. The incidence of quantitative variants was about three times higher in soluble proteins (11%) than in structure-bound proteins (3.5%); in the total cell proteins it lay in between (7%). Cultured cells (fibroblasts) and native cells (hair root cells) showed a similar degree of variation. A comparison of the data shown here with data obtained by an investigation on inbred strains of the mouse suggest that the major part of the quantitative variants observed in the 2DE patterns of proteins were genetically determined. The results presented here and the mouse data mentioned above lead us to the conclusion that the genetic variability of proteins may be characterized by quantitative changes rather than by qualitative changes, and that the genetic variability occurs to quite different degrees in different classes of proteins: structure-bound proteins〈soluble non-enzymatic proteins〈enzymes (certain groups).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284661
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  • 7
    Electronic Resource
    Electronic Resource
    Zur Gen-Lokalisierung der Glucose-6-Phosphat-Dehydrogenase bei Vögeln (1969)
    Springer
    Human genetics 〈Berlin〉 8 (1969), S. 137-141 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Kanarienvogel (Serinus) und Stieglitz (Carduelis) zeigen für das Enzym Glucose-6-Phosphat-Dehydrogenase in der Stärkegelektrophorese jeweils nur eine Bande, die aber verschiedene Positionen einnehmen. Interspecieshybriden beider Geschlechter wurden aus der natürlichen Kreuzung Kanarienvogel (f)xStieglitz (m) erhalten; die Identifizierung des Geschlechts der äußerlich ähnlichen Hybriden erfolgte durch Chromosomenanalyse. Die Hybriden zeigen in beiden Geschlechtern ein identisches Elektrophoresemuster, das die gleiche Zone umfaßt wie bei dem in vitro-Gemisch aus Gewebehomogenaten der Ausgangsarten. Entsprechende Befunde liefert die Analyse der 6-Phosphogluconatdehydrogenase. Hieraus ist zu schließen, daß beide Enzyme von autosomalen Genen determiniert werden.
    Notes: Summary The electrophoretic mobility of the single G-6-PD-band in Serinus and Carduelis is different. The natural cross Serinus (f)xCarduelis (m) results in viable hybrids of both sexes, as confirmed by chromosome analysis. The isoenzymes of G-6-PD are indentical in both sexes of the hybrids, exhibiting a broad diffuse pattern comprising the same zone as obtained from an in vitro mixture of parental homogenates. Related findings are reported on the enzyme 6-PGD. It is concluded that both enzymes are autosomally determined in these species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295837
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  • 8
    Electronic Resource
    Electronic Resource
    Asynchronous activation of parental alleles at the tissue-specific gene loci observed on hybrid trout during early development (1968)
    Springer
    Biochemical genetics 1 (1968), S. 287-300 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract By using three genetic markers, the asynchronous activation of parental alleles during embryonic development was studied on interspecific hybrids between the male brown trout and the female rainbow trout. The genetic markers used were lactate dehydrogenase (LDH) A2 as well as C subunits and alcohol dehydrogenase (ADH) subunits. Starch gel electrophoresis was utilized. The presence of LDH A2 subunits was detected from a very early stage of development in whole embryo extracts. However, up to a few days after hatching (63rd day), A2 subunits present were exclusively of the A2R type derived from the rainbow mother. The coexistence of the products of both parental alleles at this gene locus became evident only at the 70th day. The LDH C subunits which occur only in the retina of the eye as well as the ADH subunits which occur only in liver made their first appearances at the 95th and 150th days, respectively. At these dates, only the maternally derived rainbow subunits were detectable. It took another 40 days for the paternally derived brown subunits to make their appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485183
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  • 9
    Electronic Resource
    Electronic Resource
    High-resolution protein mapping of human fibroblasts and hair root cells: A standardized reproducible procedure considering the effect of cell culture parameters (1981)
    Springer
    Biochemical genetics 19 (1981), S. 871-880 
    Details
    ISSN: 1573-4927
    Keywords: protein mapping ; human fibroblasts ; hair roots ; cell culture parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The effect of different cell culture parameters on two-dimensional polypeptide maps of human fibroblasts is considered. Improved culture methods are introduced to get better resolution and reproducibility. Based on these investigations, highly standardized techniques for the protein mapping of this tissue and also of hair root cell lysates are presented. These methods seem to be quite suitable for analysis of cellular synthesized proteins and study of variability in normal subjects and in patients with genetic disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00504252
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of inborn errors of metabolism and other genetic defects in human fibroblasts using two-dimensional polypeptide mapping (1981)
    Springer
    Journal of inherited metabolic disease 4 (1981), S. 97-98 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A standardized technique for the two-dimensional polypeptide mapping of cultured human fibroblasts has been used for the study of cellular protein variations in healthy controls, patients with inborn errors of metabolism and some other genetic defects. The analysis of about 50 gels has established that this method is very reproducible and enables the examination of about 600 polypeptides in a single gel. The inter-individual variation has been rather low (about 3%). In the gels from patients with genetic defects only very minor qualitative variations have been observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263609
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