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  • Articles: DFG German National Licenses  (2)
  • 1980-1984  (2)
  • Bone  (1)
  • DMBA  (1)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1980-1984  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3 (1980)
    Springer
    Calcified tissue international 31 (1980), S. 215-223 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; 1,25(OH)2D3 ; 25OHD3 ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Rachitic rats, maintained on diets with low or normal P contents, were given daily intraperitoneal doses of 1,25(OH)2D3 or 25OHD3 at levels of 100 or 200 ng. Plasma chemistry was measured and the ash content and histological appearance of the bones investigated. Using labeled material it was shown that the dosing levels of 1,25(OH)2D3 employed ensured a higher than normal plasma concentration of that metabolite over the period between doses. 1,25(OH)2D3 was not as effective as 25OHD3 in raising bone ash or reducing the amount of osteoid. The difference between the effects of the metabolites was evident at both dietary P levels, but more marked at the higher P level. In contrast, the metabolites reduced the width of the epiphyseal plate to an approximately similar degree, and this is possibly the reason why there are discrepancies between previous reports of the effectiveness of 1,25(OH)2D3 compared with 25OHD3 or vitamin D3. Dosing with 1,25(OH)2D3 failed to maintain a constant plasma Pi value over the period between doses in animals fed the low P diet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02407184
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prolactin levels and molecular heterogeneity in rat strains with high and low incidence of DMBA-induced mammary tumors (1984)
    Springer
    Breast cancer research and treatment 4 (1984), S. 129-136 
    Details
    ISSN: 1573-7217
    Keywords: DMBA ; genetic strains ; mammary tumors ; molecular heterogeneity ; prolactin ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We compared the following parameters in Long-Evans (LE) and Sprague-Dawley (SD) female rats: 1) mammary tumor incidence after DMBA, 2) plasma prolactin (PRL) during the estrous cycle before and after DMBA, 3) plasma PRL in immature females from 0900 hr on day 29 to 0900 hr on day 30, 4) plasma PRL from 1200 to 1700 hr and before and 10 min after i.p. TRH administration in ovariectomized (OVX) rats treated with 200 µg polyestradiol phosphate (PEP), 5) anterior pituitary (AP) PRL concentration in OVX rats treated with 200µg PEP, and 6) levels and Sephadex G-100 gel filtration patterns of plasma PRL 10 min after i.p. TRH administration in OVX rats treated with 200µg PEP. We observed marked mammary tumor incidence in SD rats from one supplier (S-SD, Spartan) (96%) compared to SD from another supplier (CRSD, Charles River) (40%) or LE rats (10%). Plasma PRL was significantly decreased on metestrus-diestrus and increased on proestrus-estrus in SD (both suppliers) but not in LE rats 90 days after DMBA compared to rats not given DMBA and sacrificed at same stages of the estrous cycle on day 55 of age. Immature LE and SD-CR females exhibited significant late afternoon and early morning prolactin surges on days 29–30 whereas SD-H rats had either no surges or poorly synchronized surges at the same times. Ovariectomized mature females of the tumor-resistant strains had significantly more AP PRL than the tumor-sensitive strain when given PEP, however there were no differences between the strains in estrogen-induced afternoon PRL surges or in TRH-induced PRL release in the mature OVX, PEP-treated rats. On the other hand, Sephadex G-100 gel filtration patterns of plasma PRL in OVX LE and the tumor-resistant SD group treated with PEP and sacrificed 10 min after TRH administration were markedly different when compared with tumorsensitive SD rats. These studies indicate that there are differences in PRL secretion between strains of rats with high and low mammary tumor incidence but not all of these differences are directly related to the variation in tumorigenesis. The most promising parameters appear to be PRL secretion in immature rats and molecular heterogeneity of plasma PRL. These factors are currently under further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806395
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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