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  • 1
    Electronic Resource
    Electronic Resource
    Enrichment of CO2 and magnesium in early stages of biomineralization (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 151-152 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Simultaneous topochemical analyses of calcium, magnesium, carbonate (as CO2) and phosphorus in a mineralizing collagen rich system (turkey tibia tendon) showed a strong enrichment of Mg and CO2 in the prestages of biomineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953700
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  • 2
    Electronic Resource
    Electronic Resource
    Characteristic molar ratios of magnesium, carbon dioxide, calcium and phosphorus in the mineralizing fracture callus and predentine (1980)
    Springer
    Calcified tissue international 32 (1980), S. 257-261 
    Details
    ISSN: 1432-0827
    Keywords: Mineralization ; Collagen Rich Systems ; Fracture Callus ; Predentine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary From fracture callus in different stages of mineralization the contents of Mg, CO2, Ca and P were determined and compared with those found in predentine. It was found that the Mg- and CO2-contents are high in relation to Ca and P values during the prestages and early stages of mineralization. These relatively high Mg- and CO2-values are connected with high Mg/Ca, Mg/P, CO2/Ca and CO2/P ratios which strongly decrease with the increasing degree of mineralization. These results seem to be part of a general controlling mechanism of the calcification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408549
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  • 3
    Electronic Resource
    Electronic Resource
    Morphological studies on the epiphyseal growth plate combined with biochemical and X-ray microprobe analyses (1982)
    Springer
    Histochemistry and cell biology 74 (1982), S. 541-552 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The epiphyseal growth plate of the domestic pig was investigated topologically combining biochemical methods with electron microprobe microanalyses both correlated to histological controls. A lateral resolution of about 50 μm was reached. Highest nuclease activity was found in the lower columnar cell zone, while alkaline phosphatase showed maximal activity in the hypertrophic area, connected with maximal values for extractable, organically bound phosphorus, and extractable Ca and Mg. Acid phosphatase activity reached maximal values in the zone of the lower primary spongiosa, while the extractable Pi had maximal values at the end of the zone of bone remodelling. Microprobe analyses have shown that the extracellular Ca content (per dry mass) remained relatively constant at 0.7% (about 58 mM/kg wet weight for 66% tissue fluid) in all zones of the plate increasing to 1% in the vicinity of the first foci of mineralization. The intracellular P content (per dry mass) was about 4.5%, the extracellular 0.1–0.2% (about 10–20 mM/kg wet weight) increasing also to about 1% in the vicinity of the first foci of mineralization. Thus the Ca x P product was much higher than the ion-product of 2 mM2 which is necessary for an in vitro mineralization of connective tissue. The extracellular S content (per dry mass) as a probable indicator of sulfated proteoglycans was relatively constant at about 3.5% in the different zones but decreased to about 0.3% in the fully mineralized regions. This indicates a loss of sulfur containing substances with mineralization which is not so high since the concentrations per dry mass must be normalized to a unit volume of equal density of mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496668
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  • 4
    Electronic Resource
    Electronic Resource
    Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters (1982)
    Springer
    Journal of cancer research and clinical oncology 102 (1982), S. 227-233 
    Details
    ISSN: 1432-1335
    Keywords: Vinylethylnitrosamine (VEN) ; Syrian golden hamster ; Respiratory tract tumors ; Vinyläthylnitrosamin (VEN) ; Syrische Goldhamster ; Tumoren im Respirationstrakt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Syrische Goldhamster erhielten wöchentlich 5,0, 2,5, 1,25 oder 0,63 mg/kg Körpergewicht Vinyläthylnitrosamin (VEN) subkutan. Mit ansteigender Dosis fand sich eine geringere mittlere Überlebenszeit; es zeigte sich eine Zunahme der Tumorrate. Bezüglich der Gesamttumorrate wurden Werte zwischen 50 und 100% ermittelt. Betroffen war insbesondere der Respirationstrakt, wobei sich zum Teil positive Dosis-Wirkungsbeziehungen ergaben.
    Notes: Summary Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411342
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  • 5
    Electronic Resource
    Electronic Resource
    A fetal respiratory epithelial cell line for studying some problems of transplacental carcinogenesis in Syrian golden hamsters (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 133-144 
    Details
    ISSN: 1432-1335
    Keywords: Fetal lung epithelial cell line ; Differentiation ; MNNG transformation ; Syrian golden hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using repeated cloning and treatment with cis-HPL (200 μg/ml), an analogue of a procollagen precursor inhibitory to the growth of collagen-synthesizing cells of mesenchymal origin, clonally premature epithelial cell lines were isolated from fetal SGH lungs cultured on the 15th day of gestation. One of the cell lines, M3E3/C3, which has been extensively studied for biological characterization, developed poorly differentiated carcinomas in injected hamsters after transformation by MNNG. Moreover, when grown on collagen gel, this cell line indicated an obvious potency for in vitro differentiation in response to vitamin A by developing activated Golgi regions, well developed rER and a number of mucus-like granules. Since such a differentiative responses is expected to be definable in the light of respiratory epithelium developing in utero, this cell line may be useful for studying mechanisms of differentiation-dependent sensitivity of fetal organs to transplacental carcinogen exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402061
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  • 6
    Electronic Resource
    Electronic Resource
    Knochenheilung und dynamischer Interferenzstrom (DIC). —Erste vergleichende tierexperimentelle Studie an Schafen Teil II: Physikalische und chemische Ergebnisse (1982)
    Springer
    Langenbeck's archives of surgery 356 (1982), S. 231-241 
    Details
    ISSN: 1435-2451
    Keywords: Behavior of tissue temperature under DIC ; Hydroxyproline ; Calcifying activity ; Calcium ; Phosphorus levels ; Degree of mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zusätzlich wurden physikalische und chemische Untersuchungen über den Einfluß von dynamischem Interferenzstrom (DIC) auf die Knochenheilung durchgeführt, nachdem bei 24 Schwarzkopfschafen eine Querosteotomie des Radius vorgenommen worden war. Nach instabiler Osteosynthese wurde die Osteotomiezone wiederholt mit DIC verschiedener mA—Stärken behandelt. (Methodische Einzelheiten sind in Teil I beschrieben). Die Behandlung mit dynamischem Interferenzstrom führte im behandelten Gewebe zu steigenden Temperaturen, die von den mA—Stärken abhängig waren. Weiterhin wurden Zusammenhänge zwischen DIC—mA—Intensität und dem Vorkommen von Hydroxyprolin, einer kollagenspezifischen Aminosäure, nachgewiesen, welches eine erhöhte Calcifizierungsaktivität zur Folge hatte. Messungen des Calcium— und Phosphorgehaltes im neugebildeten Knochengewebe wiesen bei den mit DIC behandelten Tieren vollständige Mineralisation zu einem viel früheren Zeitpunkt als bei den unbehandelten, nach gleichem Verfahren operierten Kontrolltieren auf. Ob DIC einen spezifischen Reiz auf die Knochenneubildung heilender Knochen ausübt, ist noch nicht vollständig geklärt.
    Notes: Summary In the course of supplementary physical and chemical investigations of the influence ofDynamicInterferential Current (DIC) on bone healing 24 black-head sheep were subjected to transversal osteotomy of the radius. After an instable osteosynthesis the site was exposed to repeated therapy with DIC of varying mA intensity. (Methodological details are described in part 1.) DIC therapy resulted in altering the temperatures in the treated tissue, dependent on the mA intensity. Further associations were verified between DIC intensity and the occurrence of hydroxyprolin, an amino acid specific collagen, which also reflected increased calcifying activity. Measurements of the calcium and phosphorus levels in the regenerated (newly forming) bone tissue documented full mineralization in the DIC-treated animals at a much earlier date than in the untreated controls that had undergone similar operations. Whether DIC specifically stimulates osteogenesis within “healing” bones is still unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263122
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  • 7
    Electronic Resource
    Electronic Resource
    Electron-microscopic microprobe analysis on the initial stages of mineral formation in the epiphyseal growth plate (1981)
    Springer
    Cell & tissue research 217 (1981), S. 661-666 
    Details
    ISSN: 1432-0878
    Keywords: Epiphyseal plate ; Matrix vesicles ; Microprobe analysis ; Ca and P enrichment ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dry thin sections (300–500 nm thick) of shock-frozen, freeze-dried and embedded epiphyseal growth plates from the proximal tibia of guinea pigs were cut longitudinally from the plate. Dark round bodies (ø〈0.5 μm) were observed using the scanning transmission mode of the electron microscope initially directly in the vicinity of the chondrocytes. They gradually spread out in the direction of the metaphysis to the center of the longitudinal septum and represent most probably the matrix vesicles. By use of a microscan of 0.25×0.25 μm the element-concentrations of these bodies were measured. The measurements started on those bodies that could be clearly recognized and were extended to a length of 30–40 μm in the metaphyseal direction. To obtain approximate quantitative results the registered CaKα and PKα x-ray counts were directly compared with counts of fully mineralized regions, the Ca and P contents of which are known. Ca as well as P could be detected in the first visible vesicle-like structures (Ca∼0.2%, P∼0.4%) and increased steeply in the metaphyseal direction, amounting to approximately 6% Ca and 3% P. These results may lead to the conclusion that Pi becomes split from phosphate esters and transformed into the matrix vesicles already in a very early stage of enrichment. Incorporation of Ca may be coupled with this process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219372
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  • 8
    Electronic Resource
    Electronic Resource
    Polarographische Bestimmung von Cd, Cu, Pb und Zn im Verlauf der Knochenbildung bei histologisch-topologischer Zuordnung (1984)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 317 (1984), S. 653-655 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593817
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  • 9
    Electronic Resource
    Electronic Resource
    Inversvoltammetrische Bestimmung von Cd, Cu, Pb und Zn für verschiedene Stadien der Knorpelmineralisation (1982)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 311 (1982), S. 415-416 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00481781
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  • 10
    Electronic Resource
    Electronic Resource
    Knochenheilung und dynamischer Interferenzstrom (DIC) —Erste vergleichende tierexperimentelle Studie an Schafen (1982)
    Springer
    Langenbeck's archives of surgery 356 (1982), S. 219-229 
    Details
    ISSN: 1435-2451
    Keywords: Experimental study ; Sheep ; Transversal osteotomy ; Instable osteosynthesis ; Influence of dynamic interferential current ; Noninvasive procedure ; Bone healing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ziel der Untersuchung war es, einen möglichen Einfluß von dynamischem Interferenzstrom ((Dynamic Interferential Current, DIC) auf die reaktiven Veränderungen bei der Knochenheilung nach operativer Durchtrennung zu prüfen. Bei 34 Schwarzkopfzuchtschafen wurden Radius und Ulna der rechten Vorderextremität osteotomiert, der Radiusschaft deperiostalisiert und mit einer 4-Loch-AO-Platte überbrückend, unter Belassung eines mindestens 1 mm breiten Spaltes, instabil fixiert. Bei 24 Schafen behandelten wir mit dynamischem Interferenzstrom (DIC). Die übrigen Tiere dienten der Kontrolle. Die bisher gewonnenen Ergebnisse der klinischen, radiologischen, histologischen und chemischen Untersuchungen weisen auf ein dichteres Callusgefüge mit beschleunigt ablaufenden Mineralisierungsprozessen unter DIC-Behandlung in diesem Tierversuch hin.
    Notes: Summary The aim of this investigation was to clarify the influence of dynamic interferential current (DIC). Two sinusoidal currents of medium frequency are superimposed within the body to determine the reactive changes of bone healing after osteotomy. An osteotomy was performed on the radius and ulna of the right foreleg of 34 ‘black-head breeding sheep’. The radius shaft was deperiostalized and unstably fixed with a four-hole AO-plate leaving a gap of at least 1 mm width. DIC of different mA-values has used to treat 24 sheep 3 times per week for 10 min. The other 10 animals were not treated with DIC but used as control animals. The different results of our clinical, radiological, histological and chemical analyses to date indicate that callus formation is accelerated by the application of DIC. The fracture callus of treated animals is strongly mineralized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261760
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