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  • Articles: DFG German National Licenses  (23)
  • 1975-1979  (14)
  • 1970-1974  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— We have confirmed the finding of Takahashi & Aprison (J. Neurochem.11, 887-898, 1964) that more acetylcholine is found in brains of rats killed by near-freezing compared to decapitation. The radioenzymic assays for acetylcholine and choline of Shea & Aprison (Analyt. Biochem.56, 165-177, 1973) and Goldberg & McCaman (J- Neurochem.20, 1 8, 1973) were used to measure both compounds and gave very similar results. The larger amount of ACh was observed both in powders of frozen rat brain and in homogenates prepared from animals killed by near-freezing. When subcellular fractionation of the homogenates was done in the presence of eserine, the larger amount of ACh was found in the soluble fraction (S2). These results indicated that with the near-freezing method, an extra amount of ACh is preserved in a form that is originally protected from acetylcholinesterase but that becomes esterase-sensitive on fractionation since no differences were observed in P1. P2 or S2 fractions when no eserine was present. The amounts of choline in homogenates and subcellular fractions were also measured after both methods of killing. Differences in the method of killing and postmortem changes which affect the choline values obtained are described.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The effects of high circulating concentrations of several amino acids on the free amino acids of rat brain were measured, to see whether or not the results followed any consistent pattern. High circulating concentrations of large, neutral amino acids (phenylalanine, valine or isoleucine) caused significantly decreased values only of other large, neutral amino acids in the brains. High circulating concentrations of the basic amino acids lysine or arginine caused significantly decreased values only of each other. The data suggest that there are separate systems for the transport of neutral and basic amino acids across the blood-brain barrier. The effects of valine and lysine on the uptake by brain and the con-vulsant action of allylglycine (a neutral amino acid) were consistent with the concept of separate systems for the transport of amino acids across the blood-brain barrier. Valine inhibited the uptake by brain and the convulsant action of allylglycine in mice, but lysine did not. The data suggest that allylglycine and valine are transported into the brain by a common mechanism that does not transport lysine.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 143-144 
    ISSN: 1432-1440
    Keywords: Intestinal alkaline phosphatase ; bone alkaline phosphatase ; hyperthyroidism ; Alkalische Dünndarmphosphatasen ; alkalische Knochenphosphatasen ; Hyperthyreose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Parallel zu tierexperimentellen Befunden, daß Thyroxingaben zu einer erhöhten Enzymkonzentration alkalischer Phosphatasen im Dünndarmgewebe führen, konnte im Serum von 50 hyperthyreoten Patienten eine Vermehrung intestinaler alkalischer Phosphatasen nachgewiesen werden. Damit tragen neben der deutlichen Zunahme von Isoenzymen ossären Ursprungs als Folge reaktiv gesteigerter Osteoblastentätigkeit auch intestinale alkalische Phosphatasen zu der bei einer Hyperthyreose häufig zu findenden Erhöhung der Serumgesamtaktivität bei. Die angeführten Befunde sollten daher für die differentialdiagnostische Wertung des klinisch-chemischen Parameters „Gesamtaktivität der alkalischen Phosphatase im Serum“ bei der Hyperthyreose berücksichtigt werden.
    Notes: Summary According to experimental results showing increased alkaline phosphatase concentrations in the small intestine of hyperthyroid rats, elevated intestinal alkaline phosphatase serum levels were observed in hyperthyroid patients with normal liver function. Therefore, an elevation of total serum alkaline phosphatase activity in hyperthyroidism is not only due to the main increase of bone phosphatase activity but also to an increase of intestinal alkaline phosphatase activity.
    Type of Medium: Electronic Resource
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  • 5
    facet.materialart.
    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 21:9 (1973) 1080 
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1058-1060 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Steady membrane voltage fluctuations have been observed in atrial muscle fibres of the carp. These voltage fluctuations produce minute mechanical oscillations, as revealed by an interference contrast microscope. The steady voltage fluctuations may be related to abnormal automaticity in the heart.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 209 (1978), S. 39-49 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Augen eines menschlichen Embryo der sechsten Woche — 11 mm Scheitel-Steiß-Länge (SSL) — und eines menschlichen Embryo der siebenten Woche −19 mm SSL — werden untersucht. Bei dem Embryo von 11 mm SSL ist die Ablösung der Linsenblase vom Oberflächen-Ektoderm, dem späteren Hornhaut-Epithel, gerade erfolgt. Zwischen der Linsenblase und dem darüber liegenden Ektoderm erscheint das zellfreie primäre Hornhaut-Stroma. Die Feinstruktur der Ektodermzellen, ihrer Basallamina und des primären Stromas wird beschrieben. Bei dem Embryo von 19 mm SSL sind Mesenchymzellen aus der Peripherie in den Raum zwischen Ektoderm und Linse eingewandert. In diesem Stadium finden sich auffallende Veränderungen der Struktur der Hornhautepithelzellen, ihrer Basallamina und der darunter liegenden Bestandteile des primären Stromas.
    Notes: Summary The eyes of a human embryo in the 6th week, 11 mm crown-rump (C.R.) length, and of a human embryo in the 7th week, 19 mm C.R. length, were examined. In the embryo of 11 mm C.R. length, the lens vesicle had just detached from the surface ectoderm, the presumptive corneal epithelium. The acellular primary corneal stroma appeared between the lens vesicle and the overlying ectoderm. The fine structure of the ectodermal cells, of their basal lamina, and of the primary stroma is described. In the embryo of 19 mm C.R. length, mesenchymal cells had moved from the periphery into the space between the ectoderm and the lens. There were remarkable changes in the structure of the corneal epithelial cells, in their basal lamina, and in the underlying substances of the primary stroma.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 254 (1976), S. 929-929 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 254 (1976), S. 929-929 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 257 (1979), S. 220-220 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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