ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Previously used procedures for processing the amino acids from 6N hydrochloric acid hydrolysis of poly[N5-(4-hydroxybutyl)-L-glutamine], poly[N5-(3-hydroxypropyl)-L-glutamine], and several random copolymers derived from these, led to the formation of spurious products. These have been isolated and characterized as the γ-ester of glutamic acid and the hydroxyalkyl amine, and chloro-alkyl amine hydrochloride. The former reduces the observed values for glutamic acid, but the latter has no effect on them. A method is used to avoid formation of these artifacts in the amino-acid analysis. Of all the copolymers studied previously in this series, the compositions of only those containing L-serine are in error as a result of the formation of the γ-ester. A redetermination of the amino-acid compositions of the copolymer fractions studied earlier leads to slightly revised values for the Zimm-Bragg parameters σ and s of serine.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1977.360160716
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