ISSN:
1432-0428
Keywords:
Tritiated insulin
;
subcutaneous insulin injections
;
chemical analysis of injection site
;
absorption kinetics
;
local insulin degradation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01222209
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