ISSN:
0749-1581
Keywords:
3-Aryl-3-methylpiperidines
;
1H NMR
;
13C NMR
;
stereochemistry
;
conformational analysis
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H (270, 400 MHz) and 13C (22.5, 67.5 MHz) NMR spectra of a series of 2,3-3,5- and 3,6-dimethyl-3-(m-hydroxy-m-methoxy-phenyl)piperidines of proven or potential opioid ligand activity are reported. The data were analysed in terms of configuration and preferred conformation, and some key deductions were confirmed by NOED and 2D COSY experiments. In the 3,5-dimethyl derivatives, isomers with preferred axial or equatorial 3-aryl substituents were identified.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260250614
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