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  • Artikel: DFG Deutsche Nationallizenzen  (9)
  • Inorganic Chemistry  (5)
  • DNA Polymerase  (2)
  • 45Calcium Uptake  (1)
  • Actinomycin D  (1)
Datenquelle
  • Artikel: DFG Deutsche Nationallizenzen  (9)
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Activity of some enzymes of nucleic acid metabolism in developing rat liver (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 385-393 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Liver Development ; Thymidine Kinase ; DNA Polymerase ; RNA Polymerases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The increase in DNA, RNA, and nitrogen as well as the activity of some enzymes involved in nucleic acid metabolism were measured during liver development. During the perinatal period (day 18 of gestation until birth) high activities of thymidine kinase and DNA polymerase were found which decline in the early suckling period, whereas the activities of the DNA-dependent RNA polymerases show a slow continuous increase. During the juvenile period (starting about 4 weeks after birth) the values of all enzymes studied approximate to those measured in liver tissue of adult animals. The correlation of these enzymes with the growth kinetics of liver tissue is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501275
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  • 2
    Digitale Medien
    Digitale Medien
    Studies on the teratogenic phase specificity of actinomycin D in the rat (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 31-44 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Embryonic Development ; Actinomycin D ; DNA-dependent RNA Polymerases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to elucidate the phase specificity of the embryo-lethal and teratogenic action of actinomycin D (day 5–10 of gestation) rats received 3H-actinomycin D at different times of gestation. The distribution of the radioactivity in the fetus and the placenta was measured. Moreover, the effects of actinomycin D on the RNA polymerase reactions in isolated nuclei of the decidual and fetal tissue were studied. The biochemical results were correlated electron microscopically with specific alterations occurring in different structures of the total implantation sites. These studies show that the time-dependent embryo-lethal and teratogenic effects of actinomycin D result from a lesion of the embryo and the decidua. The effects of the decidua occur at an earlier time and are more pronounced as compared to those of the embryo. Since the decidua is significant for the nutrition of the embryo till closure of the yolk-sac and beginning of the yolk-sac circulation (day 10 of gestation), the direct effects of actinomycin D on the embryo are intensified by the lesion of the decidua. After day 10 of gestation till the beginning of the placental function 3H-actinomycin D passes over to the embryo. But the concentration-even after a dose of 1 mg/kg-does not suffice to inhibit in vivo RNA polymerase reactions in isolated nuclei.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00505066
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  • 3
    Digitale Medien
    Digitale Medien
    Influence of steroid replacement therapy on rat embryos of hypophysectomised mother animals (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 271 (1971), S. 103-110 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Embryonic Development ; DNA Polymerase ; Hypophysectomy ; Sex Hormones
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of estrone plus progesterone on embryonic survival were studied in hypophysectomised pregnant rats. Replacement therapy commenced 24 h prior to the ablation of the pituitary which was performed on day 6 of pregnancy. The number of viable fetuses was correlated with increasing amounts of progesterone from 24 to 84 mg/kg given in concert with a constant dose of 4 μg/kg estrone. As judged by the DNA content of the 14-day-old embryos, growth retardation was linked to the reduction of the progesterone levels. No visible malformations were recorded although the experimental period covered the phase of organogenesis. On the other hand, when measuring in isolated nuclei of 14-day-old rat embryos the activity of DNA polymerase, an enzyme the activity of which can be correlated to a certain extent to embryonic growth, it becomes obvious that after treatment with estrone in combination with low (24 or 36 mg/kg) or too high doses (84 mg/kg) of progesterone the correlation between DNA content of the embryos and DNA polymerase activity per cell diverges. This result may point to a cellular malfunction not disclosed by the macroscopic appearance of the embryos at this stage. So it can be concluded that embryonic growth and differentiation processes might be directly dependent on maternal gonadal hormones, at least till day 12 of pregnancy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01002175
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  • 4
    Digitale Medien
    Digitale Medien
    The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea-pig atria in dependence on different extracellular hydrogen ion concentrations (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 125-137 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Sympathomimetic Amines ; pH ; 45Calcium Uptake ; Contraction Force ; Guinea-Pig Atria
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Isolated, electrically stimulated left guinea-pig atria were incubated at 30° C in a Tyrode solution, the hydrogen ion concentration of which was varied by altering the percentage of the aerating CO2/O2-mixture. The increase of the extracellular hydrogen ion concentration from pH 8.0 to pH 7.0 caused a reduction of the 45calcium uptake and of the contraction force. The positive inotropic effect and the concomitantly occuring increased 45calcium uptake induced by isoprenaline and tyramine were markedly diminished at the lower pH, the response to tyramine being more affected by increased hydrogen ion concentration than that of isoprenaline. This is possibly due to a decrease in noradrenaline available at pH 7.0 for release by tyramine. Isoprenaline and tyramine enhanced the relative specific 45calcium activity (RSA) without altering the total tissue calcium content. On the contrary, the increase of the extracellular calcium concentration caused an augmentation of the relative specific 45calcium activity and the total tissue calcium content.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501847
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  • 5
    Digitale Medien
    Digitale Medien
    Beiträge zur Chemie der Alkylverbindungen der übergangsmetalle. XXV [1]. Darstellung und Eigenschaften des [Ti(CH2CN)4 · 2 THF]n (1977)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 437 (1977), S. 210-212 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XXV. Preparation and Properties of [Ti(CH2CN)4 · 2 THF]nTetracyanomethyl titanium, [Ti(CH2CN)4 · 2 THF]n, can be prepared by reaction of TiCl4 with LiCH2CN in form of a tetrahydrofuran complex. The brown, stable compound, which seems to be a coordination polymer, was characterized by i.r. and 1H-n.m.r. spectra.
    Notizen: Tetracyanmethyltitan läßt sich durch Reaktion von Titan(IV)-chlorid mit Cyanmethyllithium als braune, thermisch recht beständige, offensichtlich koordinationspolymere Verbindung der Formel [Ti(CH2CN)4 · 2 THF]n gewinnen. Eine nähere Charakterisierung erfolgte mittels des IR- und des 1H-NMR-Spektrums.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19774370130
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  • 6
    Digitale Medien
    Digitale Medien
    Beiträge zur Chemie der Alkylverbindungen von Übergangsmetallen. XXIV. Darstellung und Eigenschaften von Tetrabenzylmolybdän und -uran (1977)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 435 (1977), S. 45-48 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XXIV. Preparation and Properties of Tetrabenzyl Molybdenum and Tetrabenzyl UraniumTetrabenzyl molybdenum, (C6H5CH2)4Mo, can be obtained by the reaction of MoCl4 · 2 THF with dibenzyl magnesium. The compound forms darkbrown crystals, which are stable at room temperature. The analogous reaction of UCl4 · 3 THF with dibenzyl magnesium yields a reddish brown complex of tetrabenzyl uranium of the formula (C6H5CH2)4U · MgCl2. The synthesized compounds are characterized more in detail.
    Notizen: Tetrabenzylmolybdän, (C6H5CH2)4Mo, läßt sich durch Umsetzung von Molybdän(IV)-chlorid-bis(tetrahydrofuran) mit Dibenzylmagnesium in Form schwarzbrauner, bei Zimmertemperatur beständiger Kristalle gewinnen. Bei der analogen Reaktion von Uran(IV)-chlorid-tris(tetrahydrofuran) mit Dibenzylmagnesium entsteht ein rotbrauner Tetrabenzyluran-Komplex der Formel (C6H5CH2)4U · MgCl2.  -  Beide Verbindungen werden näher charakterisiert.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19774350105
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  • 7
    Digitale Medien
    Digitale Medien
    Beiträge zur Chemie der Alkylverbindungen von Übergangsmetallen. XVIII. Darstellung und Eigenschaften von Vanadintetrabenzyl und von Benzyltantalchloriden (1976)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 421 (1976), S. 129-134 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Contributions to the Chemistry of Transition Metal Alkyl Compounds. XVIII. On the Preparation and Properties of Tetrabenzyl Vanadium and Benzyl Tantalum ChloridesPure tetrabenzyl vanadium was isolated and characterized by elementary analyses, EPR and 1H-NMR spectra, by hydrolysis and thermal decomposition.  -  Experiments for the preparation of tetra or pentabenzyl compounds of niobium and tantalum failed, but we could prepare C6H5CH2TaCl4, (C6H5CH2)2TaCl3, and (C6H5CH2)3TaCl2, the last two in form of bipyridyl complexes.
    Notizen: Vanadintetrabenzyl wurde in definierter Form isoliert und durch Elementaranalyse, ESR- und 1H-NMR-Spektrum sowie durch die hydrolytische und thermische Spaltung charakterisiert.  -  Versuche zur Gewinnung von Tetra- und Pentabenzylverbindungen des Niobs und Tantals blieben erfolglos. Es gelang jedoch, die Verbindungen C6H5CH2—TaCl4, (C6H5CH2)2TaCl3 und (C6H5CH2)3TaCl2, zum Teil in Form von Dipyridylkomplexen, zu gewinnen.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19764210206
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  • 8
    Digitale Medien
    Digitale Medien
    Ueber eine neue Reihe von Betaïnen (1899)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 32 (1899), S. 1566-1572 
    Details
    ISSN: 0365-9496
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cber.18990320236
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  • 9
    Digitale Medien
    Digitale Medien
    Chinone anellierter Ringsysteme mit austauschfähigem Halogen im nicht-chinoiden Kern (1924)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 57 (1924), S. 496-510 
    Details
    ISSN: 0365-9631
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cber.19240570325
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