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  • Articles: DFG German National Licenses  (4)
  • Capillary electrophoresis  (2)
  • 8α-amino-ergolines  (1)
  • Conflicting demands  (1)
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  • Articles: DFG German National Licenses  (4)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 431-436 
    Details
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940539
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Feeding postures of suspension-feeding larval black flies: the conflicting demands of drag and food acquisition (1991)
    Springer
    Oecologia 85 (1991), S. 457-463 
    Details
    ISSN: 1432-1939
    Keywords: Suspension-feeding ; Boundary layers ; Drag ; Conflicting demands ; Larval black flies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We tested whether larval black flies actively control the positioning of their feeding appendages (labral fans), and if so, whether their posture represents a balance between the conflicting demands of drag and feeding. We compared the postures of live larvae with the postures of larvae killed by heat-shock in three different flow regimes in a laboratory experiment; we assumed that the postures of heat-killed larvae approximated a passive response to drag. The average height of the labral fans above the bed declined significantly in faster flows, and was significantly greater in live than dead larvae. There was also a significant interaction effect, since the difference between the fan heights of live and dead larvae was greater in slower flows. Two mechanisms may contribute to this result. Larvae in slower flows have to increase their fan heights more than larvae living in faster flows to achieve comparable increases in velocity and thus particle flux. In addition, muscular strength may limit the feeding postures larvae can assume. The fan heights of live larvae also varied depending on the concentration of food particles: larvae exposed to low food concentrations held their fans higher above the bed than did larvae exposed to high food concentrations in the same flow regime. This change in posture is due neither to an uneven particle concentration in the boundary layer nor to added drag from particles trapped in the labral fans. Collectively, our results indicate that these suspension feeders actively control their feeding posture, and suggest that these varying postures represent a dynamic balance between the conflicting needs of minimizing drag and maximizing feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00323756
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Determination of organic acid drug counter-ions by capillary electrophoresis (1997)
    Springer
    Chromatographia 44 (1997), S. 367-371 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Organic acids ; Pharmaceuticals ; Drug counter-ions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A capillary electrophoresis method is described for the novel application of quantifying levels of the simple organic acid counter-ions of a variety of basic drugs. These counter-ions are organic acids such as succinic and maleic. The method uses indirect UV detection and an electroosmotic flow modifier. Acceptable precision and detector linearity were obtained using internal standards. Method validation was completed and acceptable data was generated. The method is now in routine use for this type of testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466312
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The use of a short-end injection procedure to achieve improved performance in capillary electrophoresis (1996)
    Springer
    Chromatographia 43 (1996), S. 153-158 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Short-end injections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Minimum capillary lengths on commercial instruments are fixed and cannot be decreased further. To effectively reduce the capillary length used for separation the sample can be injected from the end of the capillary nearest the detector. This procedure is known as a ‘short-end’ injection and can reduces analysis times by at least two-thirds compared to conventional injections. The time reduction benefits are shown in rapid separations of basic drugs, drug-related impurities and chiral compounds. Short-end injections, in combination with both increased electrolyte strength and reduced voltage are an effective approach to reducing the detrimental impact of high sample solution ionic strength. They can also lead to improved resolution by increasing stacking effects and reducing peak tailing. Peak area and migration time precision obtained are shown to be equivalent to those obtained for conventional injection procedures. It is concluded that short-end injections should be considered for routine operation as they are a useful means of reducing analysis time, increasing sensitivity, decreasing buffer depletion effects. They also allow use of higher electrolyte strengths which can improve resolution and reduce peak tailing, and can overcome significant problems which occur when analysing samples containing high salt contents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02292944
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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