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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of AIDS-related non-Hodgkin's lymphoma with chemotherapy (CNOP) and r-hu-G-CSF: Clinical outcome and effect on HIV-1 viral load (1998)
    Springer
    Annals of oncology 9 (1998), S. 1135-1138 
    Details
    ISSN: 1569-8041
    Keywords: AIDS ; chemotherapy ; G-CSF ; HIV-1 viral replication ; non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The optimal treatment of AIDS-related NHL (ARL) has yet to be defined. The purpose of this study was 1) to evaluate the efficacy and toxicity of the CNOP-regimen (cyclophosphamide, mitoxantrone, vincristine, and prednison) in combination with G-CSF; and 2) to study the effect of this regimen on HIV-1 viral replication. Patients and methods: A phase II study was performed in 21 previously untreated patients with ARL. Results: Based on intention to treat, the response rate was 43%: four complete and five partial remissions. Median survival was only five months. Only one patient had an opportunistic infection during treatment; three patients had localized infections and one episode of septicaemia was seen. Remarkably, during treatment, in 94% of cases p24 antigen levels either remained undetectable or showed a substantial decrease, even though antiretroviral therapy had been discontinued just prior to the first cycle of chemotherapy in all patients. HIV-1 RNA load decreased or remained unchanged in 82% of patients and increased in three patients. Conclusions: Our data demonstrate, 1) that the CNOP-regimen in combination with G-CSF, although associated with a low risk of both opportunistic and bacterial infections, can not be recommended in the treatment of ARL; but 2) that G-CSF can be used safely to sustain haematopoiesis in patients with ARL treated with chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008484522952
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  • 2
    Electronic Resource
    Electronic Resource
    Synthese von bipolaren Ionenaustauscherharzen (1987)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 329 (1987), S. 483-492 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis of Bipolar Ion Exchange ResinsSyntheses of weakly acid/strongly basic and weakly acid/weakly basic bipolar ion exchange resins with varying acid and basic capacities via subsequent introduction of the exchange active groups in suitable crosslinked skeletal polymers are described.Methylacrylate-styrene-divinylbenzene polymers of varying composition which can be quantitatively chloromethylated and subsequently fully aminated (trimethylamine) and partially saponified in one process step were used as starting polymers for weakly acid/strongly basic resins. The reverse route saponification of the ester groups first, followed by chloromethylation of the aromatic parts of the matrix and animation turned out to the possible, if at all, only for bipolar resins of strongly predominant basic character. The capacity parameters can be controlled through the composition of the matrix.Polymethylacrylates crosslinked with divinylbenzene served as polymer basis of the weakly acid/weakly basic bipolar ion exchange resins. The functionalization was achieved by partial aminolysis with polyamines (dimethylaminopropylamine, ethylenediamine, diethylenetriamine) and saponification with lyes. The number of basic and acid groups which can be introduced is governed primarily by the conditions of the aminolysis. The capacity parameters are controllable within a broad range by the procedures.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19873290315
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  • 3
    Electronic Resource
    Electronic Resource
    Über den Struktureinfluß von Kieselgelen auf die Trennung von flüssigen Kohlenwasserstoffen (1959)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 9 (1959), S. 237-246 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Der Einfluß der Struktur verschiedenartiger Kieselgele auf die chromatographische Trennung typischer flüssiger Kohlenwasserstofftestgemische wird beschrieben und die Wirkung von Oberfläche, Porengröße und Korngröße auf den Trenneffekt diskutiert. Eine vollständige Auftrennung läßt sich bei den gewählten Testgemischen mit Kieselgelen mittleren Porendurchmessers (50-60 Å) erzielen. Im Gegensatz dazu ist die Trennwirksamkeit eng- und weitporiger Kieselgele deutlich abgeschwächt.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19590090504
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  • 4
    Electronic Resource
    Electronic Resource
    Flüssige Ionenaustauscher. 2. Beobachtungen bei der Synthese von Di-2-äthylhexylphosphatDiese Arbeit ist ein Teilauszug aus der Dissertation K. HÄUPKE, Math.-Nat. Fakultät der Universität Halle. (1966)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 33 (1966), S. 206-212 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Synthese von Di-2-äthylhexylphosphat aus 2-Äthylhexanol und POCl3 ergab sich eine Abhängigkeit der Zusammensetzung des aus Di-2-äthylhexylphosphat und dem Nebenprodukt Mono-2-äthylhexylphosphat bestehenden Endproduktes von der Dauer der gegenseitigen Einwirkung bei erhöhter Temperatur. Während die Gesamtausbeute an Ester durch ein Maximum läuft, schwankt das Verhältnis Mono- zu Di-2-äthylhexylphosphat periodisch.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19660330314
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  • 5
    Electronic Resource
    Electronic Resource
    Über den Zusammenhang zwischen Konstitution und insektizider Wirkung einiger Acetylphenylester der Phospor- und Thiophosphorsäure (1968)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 37 (1968), S. 243-251 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurden verschiedenartig substituierte Acetylphenylester der Phosphor- und Thiophosphorsäure hergestellt und deren Wirksamkeit gegen Musca domestica geprüft. Es zeigte sich, daß eine lineare Abhängigkeit sowohl zwischen dem LD50-Wert und dem pK-Wert als auch zwischen dem LD50-Wert und der Verschiebung der Frequenz der OH-Valenzschwingung der zur Veresterung herangezogenen Phenole besteht, wenn diese in m- oder p-Stellung substituiert sind. Bei mehrfacher Substitution konnte diese Übereinstimmung nicht gefunden werden, da durch Wasserstoffbrückenbindung (o-Acetylphenol) oder sterische Hinderung, speziell bei angularen Erstsubstituenten (NO2- und COCH3Gruppe), die erwarteten Substitutionseinflüsse nicht voll wirksam werden.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19680370504
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  • 6
    Electronic Resource
    Electronic Resource
    Vergleichende Untersuchungen an temperaturbeständigen Pigmenten auf Basis 3-Amino-phthalsäureimid. I (1971)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 313 (1971), S. 301-308 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurden hochtemperaturbeständige Azopigmente auf der Basis von 3-Amino-phthalsäureimid hergestellt. Durch Einführung von Chlorsubstituenten konnte die Lichtechtheit günstig beeinflußt werden. Die Migrationsechtheit wurde durch Molekülverdopplung entscheidend verbessert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19713130215
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  • 7
    Electronic Resource
    Electronic Resource
    Ortho-ana-Dibromchinolin (1895)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 51 (1895), S. 490-497 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.18950510141
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  • 8
    Electronic Resource
    Electronic Resource
    Wirtschaftlicher Teil u. Vereinsnachrichten (1919)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 32 (1919), S. W233 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19190322902
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  • 9
    Electronic Resource
    Electronic Resource
    Source of the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of cambendazole (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 190-191 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined gas chromatography-mass spectrometry and isotope labeling techniques have been employed to demonstrate that the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of 2-thiazolyl-5-isopropoxycarbonylaminobenzimidazole (cambendazole), is derived wholly from the parent drug. [15N] Thiazole-labeled cambendazole was administered to a rat and the metabolite isolated from urine. Trideutero-2-carboxamido-5-isopropoxycarbonylaminobenzimidazole was employed as a carrier to isolate the metabolite in sufficient purity for isotope ratio measurements using multiple ion detection. The metabolite was converted to its tetramethyl derivative by on-column reaction with trimethylanilium hydroxide to permit satisfactory gas chromatography.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010308
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  • 10
    Electronic Resource
    Electronic Resource
    Gemeinsame Spurenanalyse von H2S und COS in SO2-haltigen Abgasen (1967)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 39 (1967), S. 945-948 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In Gegenwart eines großen SO2-Überschusses ist die quantitative polarographische COS-Spurenbestimmung in Diäthylamin/Äthanol als Grundlösung möglich, wenn das SO2 ganz oder teilweise durch Braunstein oder Silicagel gebunden wird. COS und H2S lassen sich gemeinsam bestimmen, wenn die SO2-Menge in 25 ml Grundlösung etwa 5 mg SO2 nicht übersteigt. Die quantitative polarographische Analyse von H2S-Spuren in Gegenwart eines großen SO2-Überschusses gelingt in Hydrazinhydrat/Äthanol als Grundlösung.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330391603
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