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  • Artikel: DFG Deutsche Nationallizenzen  (2)
  • ATP  (1)
  • C-peptide  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 41 (1991), S. 263-265 
    ISSN: 1432-1041
    Schlagwort(e): Metformin ; Glibenclamide ; NIDDM ; lipoproteins ; C-peptide ; diabetes mellitus ; adverse effects ; serum lipids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary. Twenty-two NIDDM patients completed an open randomized cross-over study comparing metformin and glibenclamide over 1 year. The drugs had an equivalent effect on glycaemic control, but, in contrast to glibenclamide, metformin reduced body weight. Neither drug affected triglycerides, total-and LDL-cholesterol or C-peptide. Metformin caused a slight elevation of HDL-cholesterol (P 〈 0.05). No serious adverse effects were observed. The results show that oral hypoglycaemic agents are not associated with undesirable effects on lipids and lipoproteins.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of applied physiology 52 (1984), S. 243-246 
    ISSN: 1439-6327
    Schlagwort(e): Lactate ; Glycogen ; ATP ; Creatine phosphate ; Glucose ; Glucose-6-phosphate ; Arm exercise
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Five elite flatwater kayak paddlers were studied during indoor simulated 500 and 10,000-m races, with performance times of 2 and 45 min, respectively. Muscle biopsies were obtained from the midportion of m. deltoideus immediately pre and post exercise. Concentrations of adenosine triphosphate (ATP), creatine phosphate (CP), glucose, glucose-6-phosphate (G-6-P), glycogen, and lactate were subsequently determined. Short term exercise resulted in statistically significant increases in glucose (P〈0.001), G-6-P (P〈0.05) and lactate (P〈0.01) concentration concomitant with decreased CP (P〈0.05) and glycogen (P〈0.01). Following prolonged exercise, a non-significant elevation in glucose and a reduction (P〈0.01) in glycogen were demonstrated. Evidently the metabolic demands for kayak competitions at 500 and 10,000 m are different. Thus, the energy contribution from glycolytic precursors and the anaerobic component is of greater relative importance in short distances than in exercise of long duration. A generalization of the findings to other athletic events of varying distances is proposed. The present data on arm-exercise is consistent with previous findings obtained in connection with leg exercises.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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