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  • Articles: DFG German National Licenses  (2)
  • Aerosil  (1)
  • calcitonin gene related peptide.  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus (1997)
    Springer
    Diabetologia 40 (1997), S. 256-261 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Amylin ; hypertension ; calcitonin ; ACE inhibition ; calcitonin gene related peptide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amylin (or islet amyloid polypeptide) has been reported to have binding sites in the central nervous system and the kidney and has been shown to activate plasma renin. It has been postulated that this peptide may be an important mechanistic link between hypertension and diabetes in the insulin resistance syndrome. To explore this issue, the effects of rat amylin on mean arterial blood pressure were investigated in anaesthetised rats. Amylin elicited a pressor response of approximately 10 mmHg (maximal at 100 pmol · kg–1) which was apparent within 30–60 s and persisted over 15 min. At higher concentrations amylin elicited a hypotensive response (negative log IC50 8.52 mol · kg–1). The novel amylin receptor antagonist AC413 (12 nmol · kg–1· min–1) reduced the pressor response but not the hypotensive effects of amylin. The peptide antagonist calcitonin gene-related peptide (CGRP)8–37 (12 nmol · kg–1· min–1) reduced the pressor response elicited by amylin and also antagonized the hypotensive effect of amylin. Pre-treatment of animals with the ganglion blocker mecamylamine (3 mg · kg–1 s. c.) reduced the pressor effect of amylin. Following the administration of the angiotensin converting enzyme inhibitor ramiprilat (300 nmol · kg–1 i. v.) the pressor response to amylin was reduced. Salmon calcitonin also elevated blood pressure in the anaesthetised rat; doses of amylin and salmon calcitonin associated with a pressor effect were associated with increases in plasma renin activity. We conclude that amylin may act centrally to elevate blood pressure in the anaesthetised rat, possibly through activation of the renin angiotensin system. [Diabetologia (1997) 40: 256–261]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050672
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The kinetics of silylation of hydroxylated silica 1: Aerosil (1994)
    Springer
    Colloid & polymer science 272 (1994), S. 1602-1610 
    Details
    ISSN: 1435-1536
    Keywords: Aerosil ; silylation kinetics ; trimethylchlorosilane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The kinetics of the silylation of hydroxylated silica, the non-porous Aerosil using trimethylchlorosilane, under various reaction conditions has been investigated by a gravimetric technique and found to follow the law: $$\left[ {\frac{{1 + b}}{t}} \right]\ln \left\{ {\frac{{M_\infty }}{{M_\infty - M_t }}} \right\} - \frac{{M_t b}}{{M_\infty t}} = k_{\text{a}} $$ which represents a first order reaction retarded by one of its products. From this analysis, the activation energy in the temperature range 598 K to 673 K, was found to be 155 kJ mol−1. The reaction is independent of pressure at values greater than 15 torr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00664728
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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