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  • 1
    Electronic Resource
    Electronic Resource
    Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus (1997)
    Springer
    Diabetologia 40 (1997), S. 256-261 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Amylin ; hypertension ; calcitonin ; ACE inhibition ; calcitonin gene related peptide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amylin (or islet amyloid polypeptide) has been reported to have binding sites in the central nervous system and the kidney and has been shown to activate plasma renin. It has been postulated that this peptide may be an important mechanistic link between hypertension and diabetes in the insulin resistance syndrome. To explore this issue, the effects of rat amylin on mean arterial blood pressure were investigated in anaesthetised rats. Amylin elicited a pressor response of approximately 10 mmHg (maximal at 100 pmol · kg–1) which was apparent within 30–60 s and persisted over 15 min. At higher concentrations amylin elicited a hypotensive response (negative log IC50 8.52 mol · kg–1). The novel amylin receptor antagonist AC413 (12 nmol · kg–1· min–1) reduced the pressor response but not the hypotensive effects of amylin. The peptide antagonist calcitonin gene-related peptide (CGRP)8–37 (12 nmol · kg–1· min–1) reduced the pressor response elicited by amylin and also antagonized the hypotensive effect of amylin. Pre-treatment of animals with the ganglion blocker mecamylamine (3 mg · kg–1 s. c.) reduced the pressor effect of amylin. Following the administration of the angiotensin converting enzyme inhibitor ramiprilat (300 nmol · kg–1 i. v.) the pressor response to amylin was reduced. Salmon calcitonin also elevated blood pressure in the anaesthetised rat; doses of amylin and salmon calcitonin associated with a pressor effect were associated with increases in plasma renin activity. We conclude that amylin may act centrally to elevate blood pressure in the anaesthetised rat, possibly through activation of the renin angiotensin system. [Diabetologia (1997) 40: 256–261]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050672
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  • 2
    Electronic Resource
    Electronic Resource
    “Anomalous” Water (1969)
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 394-394 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-Donahoe's recent letter (Nature, 224, 198; 1969) prompts us to draw attention to the present uncertainty concerning the nature and properties of "anomalous" water. First, it must be emphasized that, whatever the correct interpretation may be, several of Derjaguin's experimental observations ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/224394a0
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  • 3
    Electronic Resource
    Electronic Resource
    Electrical and neurotransmitter activity of mature neurons derived from mouse embryonic stem cells by Sox-1 lineage selection and directed differentiation (2004)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 20 (2004), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sx1TV2/16C is a mouse embryonic stem (ES) cell line in which one copy of the Sox1 gene, an early neuroectodermal marker, has been targeted with a neomycin (G418) selection cassette. A combination of directed differentiation with retinoic acid and G418 selection results in an enriched neural stem cell population that can be further differentiated into neurons. After 6–7 days post-plating (D6–7PP) most neurons readily fired tetrodotoxin (TTX)-sensitive action potentials due to the expression of TTX-sensitive Na+ and tetraethylammonium (TEA)-sensitive K+ channels. Neurons reached their maximal cell capacitance after D6–7PP; however, ion channel expression continued until at least D21PP. The percentage of cells receiving spontaneous synaptic currents (s.s.c.) increased with days in culture until 100% of cells received a synaptic input by D20PP. Spontaneous synaptic currents were reduced in amplitude and frequency by TTX, or upon exposure to a Ca2+-free, 2.5 mm Mg2+ saline. S.s.c. of rapid decay time constants were preferentially blocked by the nonNMDA glutamatergic receptor antagonists CNQX or NBQX. Ca2+ levels within ES cell-derived neurons increased in response to glutamate receptor agonists l-glutamate, AMPA, N-methyl-d-aspartate (NMDA) and kainic acid and to acetylcholine, ATP and dopamine. ES cell-derived neurons also generated cationic and Cl–-selective currents in response to NMDA and glycine or GABA, respectively. It was concluded that ES-derived neurons fire action potentials, receive excitatory and inhibitory synaptic input and respond to various neurotransmitters in a manner akin to primary central neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.2004.03782.x
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  • 4
    Electronic Resource
    Electronic Resource
    USE OF KRYPTON FOR SURFACE AREA MEASUREMENTS (1962)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 66 (1962), S. 182-185 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100807a508
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  • 5
    Electronic Resource
    Electronic Resource
    Topic 1 Structure of materials and control of porosity: influence of processes on the microstructure of materials (1988)
    Springer
    Materials and structures 21 (1988), S. 125-126 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02472844
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  • 6
    Electronic Resource
    Electronic Resource
    Topic 1 The influence of processing on the microstructure of materials (1988)
    Springer
    Materials and structures 21 (1988), S. 83-84 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02472838
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  • 7
    Electronic Resource
    Electronic Resource
    Colligative Properties of Anomalous Water (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 1033-1037 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Investigations of the phase behaviour on freezing and subsequent melting and of other properties indicate that anomalous water is a solution containing a fixed amount of relatively involatile material in normal water. There seems to be no need to postulate the existence of a new polymer of water in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2261033a0
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  • 8
    Electronic Resource
    Electronic Resource
    Lichtstreuung und Kapillarkondensation in porösen Medien (1979)
    Springer
    Colloid & polymer science 257 (1979), S. 559-559 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626256
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  • 9
    Electronic Resource
    Electronic Resource
    The kinetics of silylation of hydroxylated silica 1: Aerosil (1994)
    Springer
    Colloid & polymer science 272 (1994), S. 1602-1610 
    Details
    ISSN: 1435-1536
    Keywords: Aerosil ; silylation kinetics ; trimethylchlorosilane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The kinetics of the silylation of hydroxylated silica, the non-porous Aerosil using trimethylchlorosilane, under various reaction conditions has been investigated by a gravimetric technique and found to follow the law: $$\left[ {\frac{{1 + b}}{t}} \right]\ln \left\{ {\frac{{M_\infty }}{{M_\infty - M_t }}} \right\} - \frac{{M_t b}}{{M_\infty t}} = k_{\text{a}} $$ which represents a first order reaction retarded by one of its products. From this analysis, the activation energy in the temperature range 598 K to 673 K, was found to be 155 kJ mol−1. The reaction is independent of pressure at values greater than 15 torr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00664728
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  • 10
    Electronic Resource
    Electronic Resource
    Relative permeabilities of a near critical binary fluid (1992)
    Springer
    Transport in porous media 9 (1992), S. 241-260 
    Details
    ISSN: 1573-1634
    Keywords: Flow in porous media ; critical phenomena ; consolute temperature ; relative permeability ; capillary desaturation ; wetting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract Relative permeabilities were measured at very low interfacial tensions (IFT) for two-phase mixtures of methanol and hexane flowing through Clashach sandstone. These two components pass from a two- to a single-phase system as the temperature is increased above the critical solution temperature (CST). The interfacial tension between the coexisting phases approaches zero as the solution reaches miscibility. The phase behaviour of methanol and hexane mixtures has been well characterised allowing the calculation of relative permeabilities, saturations and capillary numbers. Flow data are reported for four different temperatures in the two-phase region (i.e., four values of IFT and capillary number). The capillary desaturation curve (CDC) for the strongly wetting methanol rich phase is also presented. In addition to the novel technique presented for measurement of relative permeability, the results indicate that relative permeabilities approach straight line functions very near the critical point. Furthermore, desaturation of the wetting phase was found to be dependent on the capillary number which, in turn, depends on the location of the mixture on the fluid phase diagram and the proximity to the critical temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00611969
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