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  • Articles: DFG German National Licenses  (6)
  • Analytical Chemistry and Spectroscopy  (2)
  • Ehrlich ascites tumor  (2)
  • Graft rejection  (2)
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  • Articles: DFG German National Licenses  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    Induction of cell arrest at G1/S and in G2 after treatment of Ehrlich ascites tumor cells with metallocene dichlorides and cis-platinum in vitro (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 44-52 
    Details
    ISSN: 1432-1335
    Keywords: Metallocene dichlorides ; cis-Diammine-dichloroplatinum(II) ; Ehrlich ascites tumor ; Cytokinetics in vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of in vitro application of the cytostatic agents titanocene dichloride (TDC), vanadocene dichloride (VDC), and cis-diamminedichloroplatinum(II) (DDP) on the cytokinetic behavior of EAT cells was investigated. All three substances induced similar cytokinetic phenomena that are characterized on the one hand, by an accumulation of cells in the late S phase and in the G2 phase during exposure periods of 8 to 20 h. On the other hand, some cells were apparently arrested at the end of the G1 phase and, after removal of the cytostatic agents, moved through the following S, G2, and M phases as synchronized cell populations. In view of this unusual cytokinetic pattern of multiple effects, it is argued that the striking similarities in cytokinetic behavior after treatment with the three different cytostatic substances indicate analogies in their molecular mechanisms of action. The different alteration patterns observed after in vivo application of the drugs are obviously due to additional processes occurring only in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399896
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Wirkung von Acetylsalicylsäure und einem Pyrido-pyrimidin-Derivat auf die Abstoßung allotransplantierter Nieren im Tierexperiment (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 67-73 
    Details
    ISSN: 1433-8580
    Keywords: Renal transplantation ; Graft rejection ; Platelet thrombi ; Antiaggregating drugs ; Nierentransplantation ; Transplantatabstoßung ; Thrombocytenthromben ; Thrombocytenaggregationshemmende Pharmaka
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Thrombocytenaggregationshemmende Pharmaka — Acetylsalicylsäure und 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-Sulfattrihydrat—werden in ihrer Wirkung auf Abstoßungsreaktionen bei allotransplantierten Nieren an Hunden untersucht. Klinisch findet sich keine Wirksamkeit der Medikamente, dagegen zeigen interessanterweise die histologischen Befunde bei der Acetylsalicylsäuregruppe eine verminderte Abstoßungsreaktion.
    Notes: Summary The effects of anti-thrombotic drugs—Acetyl-salicylic-acid and 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-sulfat-trihydrat—on rejection reactions of renal allografts in dogs have been studied. From the clinical point of view no effectiveness of the two drugs can be found, whereas the histological findings do clearly show diminished rejection reactions in the Acetylsalicylic-acid group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856451
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Der Einfluß von Azetylsalizylsäure und Dipridamol auf die Abstoßung allotransplantierter Hundenieren bei präsensibilisierten Empfängern (1976)
    Springer
    Research in experimental medicine 169 (1976), S. 109-122 
    Details
    ISSN: 1433-8580
    Keywords: Renal transplantation ; Graft rejection ; Platelet thrombi ; Antiaggregating drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of antiaggregating agents - acetylsalicyclic acid (ASA) and dipyridamol - on the rejection of allotransplanted canine kidneys in presensitized animals were studied. Blood flow dropped more markedly in the control group than in the group treated with ASA and dipyridamol. 24 hours after transplantation the blood flow in this group was significantly higher than in the control group (p 2,5 %) and in the third group treated with dipyridamol alone. The cellular rejection started earlier and was more pronounced in the control group. Only in this group vascular rejection and microthrombi were demonstrated. Urine output ceased 24 to 60 hours after transplantation. The immunosuppressive, antiphlogistic and platelet antiaggregating effect of the combined ASA and dipyridamol therapy is thought to be responsible for the better results in this group. In this experimental model the combined treatment of ASA and dipyridamol results in a later onset of cellular rejection, in better blood-flow of the kidney and later onset of anuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851172
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cytokinetic behavior of Ehrlich ascites tumor after in vivo treatment with cis-diamminedichloroplatinum(II) and metallocene dichlorides (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 21-30 
    Details
    ISSN: 1432-1335
    Keywords: cis-Diamminedichloroplatinum(II) ; Titanocene dichloride ; Vanadocene dichloride ; Ehrlich ascites tumor ; Pulse-cytophotometry ; cis-Diammindichloroplatin(II) ; Titanocen-dichlorid ; Vanadocen-dichlorid ; Ehrlich-Aszites-Tumor ; Impulscytophotometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gegenstand der Untersuchungen ist der Einfluß einer in-vivo-Behandlung mit optimal tumorhemmenden Dosen von cis-Diammindichloroplatin(II) (DDP), Titanocen-dichlorid (TDC) und Vanadocen-dichlorid (VDC) auf das impulscytophotometrisch bestimmte DNA-Verteilungsmuster und die Mitoseaktivität von EAT-Zellen. Während DDP eine sofortige und langandauernde Unterdrückung der Zellteilungen, jedoch keine Veränderung des zellkinetischen Verhaltens von EAT-Zellen bewirkt, verursacht TDC die Ausbildung eines deutlichen,: 10–12 h nach Behandlung maximalen G2-Blocks. Im Falle von DDP und TDC werden die Tumorzellen einige Tage nach Behandlung durch Zellen des wirtstiereigenen Abwehrsystems beseitig. VDC hingegen ruft die Entstehung teilsynchroner Wellen nach einer vorübergehenden Mitosehemmung und einer reversiblen Zellakkumulation in der späten S-und der G2-Phase hervor. Darüber hinaus werden 5–16% der Zellen nach VDC-Behandlung polyploid.
    Notes: Summary The influence of an in vivo treatment with optimally tumor-inhibiting doses of cis-diamminedichloroplatinum(II) (DDP), titanocene dichloride (TDC), and vanadocene dichloride (VDC) on the DNA distribution pattern, determined by pulse-cytophotometry, and on the, mitotic activity of EAT cells is investigated. Whereas DDP causes an immediate and, long-lasting decrease of mitoses but no disturbances of the EAT cell kinetics, a marked G2 block with a maximum at 10–12 h a. t. and an irreversible and extensive mitotic depression is evoked by TDC. In the case of DDP and TDC, the tumor cells are removed several days a. t. by cells belonging to the defensive system of the host animals. In contrast, VDC induces partially synchronized waves after a transient suppression of mitoses and reversible cell accumulation in the late S and in the G2 phases. Additionally, 5–16% of the cells become polyploid after VDC treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410531
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Isomerisierung von Methoxy- und Carbomethoxysubstituierten Cycloalkyl- und Alken-radikalkationen (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1979), S. 244-253 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The very complex isomerization patterns of methoxy and carbomethoxy substituted cycloalkanes (3- to 7-membered rings) have been investigated using collisional activation, metastable ion characteristics and field ionization kinetics. The extent of isomerization depends on both the ring size and the substituent. Irrespective of the electronic properties of the substituent, ring opening involves exclusively the C-1—C-2 bond whereby linear alkene radical cations are formed. In the case of OCH3- and COOCH3 substituents the position of the resulting double bond (terminal or α,β-unsaturated) is determined more by the ring size of the precursor molecules and less by the electronic properties of the substituents. Contrary to these findings alklyl substituted cycloalkanes (3- to 5-membered rings) rearrange exclusively to terminal alkene radical cations. The barrier for double bond isomerization seems to be substantially influenced by substituents.
    Notes: Unter Benutzung mehrerer Techniken, wie Stoßaktivierung, Charakteristik metastabiler Ionen und Feldionisationskinetik, wird das äußerst komplexe Isomerisierungsverhalten von methoxy- und caarbomethoxysubstituierten Cycloalkanen (drei-bis siebengliedrege Ringe) analysiert. Das Ausmaß der Isomerisierung hängt sowohl von der Ringgröße als auch vom Substituenten ab, während die Ringöffnung unabhängig von den elektronischen Eigenschaften der Substituenten immer die C-1—C-2-Bindung betrifft. Hierbei werden ausschließlich lineare Alken-Radikalkationen erzeugt. Bei OCH3- und COOCH3-Substituenten wird die Lage der resultierenden Doppelbindung terminal oder α,β-ungesättigt hauptsächlich durch die Ringgröße des Cycloalkan-Molekülions und weniger durch den Substituenten beeinfluß. Alkylsubstituierte Cycloalkane (drei- bis fünfgliedrige Ringe) lagern sich allerdings nur zu terminalen Alken-Radikalkationen um. Die Barriere der Doppelbindungswanderung scheint vom Substituenten abhängig zsu sein.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210140504
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Raman excitation profiles from pigments in vivo (1986)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 17 (1986), S. 51-53 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman excitation profiles (REPs) for bands of carotenoid and chlorophyll b (Chl b) from whole cells of green algae at low temperatures are presented. In addition to preventing thermal destruction of the samples during long-term irradiation, the use of a double channel surface scanning technique allowed the recording of the Raman spectrum of a non-resonating substance such as acetone suitable as an intensity reference at the same time. The measured REPs are compared with the absorption spectrum of whole cells at low temperatures.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250170111
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    Paper (German National Licenses)
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