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  • Articles: DFG German National Licenses  (4)
  • Angiotensin II  (2)
  • Storage disease  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of angiotensin II and saralasin on motor activity and the passive avoidance behavior of rats
    Amsterdam : Elsevier
    Peptides 9 (1988), S. 475-479 
    Details
    ISSN: 0196-9781
    Keywords: Angiotensin II ; Angiotensin II antagonist ; Motor activity ; Passive avoidance ; Stereotypy
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(88)90150-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Topographic heterogeneity of amyloid B-protein epitopes in brains with various forms of neuronal ceroid lipofuscinoses suggesting defective processing of amyloid precursor protein (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 26-34 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal ceroid lipofuscinosis ; Batten disease ; Lipopigment ; Storage disease ; Amyloid precursor protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To verify our hypothesis of defective protease inhibitor domains that are encoded by abnormal processing of amyloid precursor protein (APP) in brains of patients with neuronal ceroid lipofuscinoses (NCL), immunohistochemical and cytochemical studies were performed with monoclonal antibodies (mAbs) directed against various domains of APP. For the studies, 22 autopsy brains were used: 12 with different forms of NCL, and 10 control brains. The staining procedure for the avidin-biotin complex (ABC) technique and the postembedding gold-labelled procedure for electron microscopy (EM) were employed. Of all mAbs used for the study, only mAbs generated against amyloid B-protein bound to neural tissue were affected with NCL. The strongest immunostaining of neurons and of some reactive glial cells was found in brains with the juvenile form of NCL. Only in the infantile form of the disease were some neurons overloaded with storage material weakly immunoreactive. In brains of patients with the adult form of NCL, immunoreactivity was found in affected neurons and in extracellularly deposited material of senile plaques. The results of EM study showed that the immunoreactivity was restricted to lysosomal cytosomes in neural tissue with any form of NCL selectively localized on the curvilinear and fingerprint proteinaceous component of ceroid lipofuscin. Studies performed on control aging brains and Alzheimer's disease (AD) brains confirmed previous observations of immunoreactivity being found diffusely in the protein component of some neurons containing lipopigment. The defective processing of APP in brains with NCL and AD and in ageing brains is discussed. Our present results support the notion of heterogeneity of ceroid lipofuscin storage material in various forms of NCL and underline the hypothesis that abnormalities found in the protease inhibitors or APP in the proteinaceous composition of storage lipopigment could be a key to the unknown etiology of NCL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294218
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The adult and a new late adult forms of neuronal ceroid lipofuscinosis (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 461-468 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal ceroid lipofuscinosis ; Kufs' disease ; Ceroid lipopigment ; Storage disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cases of the late adult form of neuronal ceroid lipofuscinosis (NCL) are reported. Two of these are siblings with a late clinical onset at ages 26 and 44 years. The third case, sporadic, has the oldest reported age for the onset of NCL, at 63 years and may be regarded as the first example of the “presenile” form of NCL. The clinical, morphological, histochemical, ultrastructural and genetic features of these three cases are discussed. The literature of the clinicopathological NCL cases with an onset at age of 25 and older is reviewed. The clinical and morphological differences between the late adult form and the presenile form of NCL as well as the difficulties in making the diagnosis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310021
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The role of dopamine in the facilitatory effect of angiotensin II on impaired learning in rats chronically treated with ethanol (1988)
    Springer
    Psychopharmacology 96 (1988), S. 500-504 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Angiotensin II ; Active avoidance ; Dopaminergic system ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats with impaired active avoidance induced by chronic (9 weeks) administration of ethanol were studied. Angiotensin II (ANG II) administered (ICV, 2.0 μg) 12 h after the withdrawal of the alcohol not only neutralized the toxic effect of ethanol but also improved learning. When administered on the 5th day after ethanol withdrawal, the effect of ANG II was weaker. Tests of stereotypy and catalepsy were used to study the possible role of the dopaminergic system in this action of ANG II. It was shown that both chronic alcohol treatment and ANG II alone increased apomorphine (1 mg/kg) and amphetamine (7.5 mg/kg) stereotypy but the effects of ANG II were greater. ANG II did not change the stereotypy induced by amphetamine but increased the stereotypy induced by apomorphine in the group of animals chronically treated with alcohol. Haloperidol — induced catalepsy was reduced in these rats. ANG II alone intensified catalepsy and eliminated the effect of ethanol. Both ANG II and alcohol increased striatal dopamine (DA) concentration. This effect of ANG II was significantly greater in the animals chronically treated with alcohol. The above changes were not observed after the DA level had been reduced by alpha-methyl-p-tyrosine (250 mg/kg), nor were changes observed in the striatal DOPAC. The results suggest involvement of the central dopaminergic system in the effect of ANG II on the ethanol — induced impairment of acquisition of active avoidance but, however, the results of the biochemical determinations of DA turnover do not provide an explanation of these changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180031
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    Paper (German National Licenses)
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