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  • Articles: DFG German National Licenses  (11)
  • Parkinson's disease  (6)
  • Beech forest  (5)
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  • Articles: DFG German National Licenses  (11)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    International (NL-UK) double-blind study of Sinemet CR and standard Sinemet (25/100) in 170 patients with fluctuating Parkinson's disease (1996)
    Springer
    Journal of neurology 243 (1996), S. 235-240 
    Details
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Motor fluctuations ; Sinemet CR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred and seventy patients with fluctuating Parkinson's disease participated in an international clinical trial to compare the effects of controlled-released Sinemet 50/200 (mg carbidopa/mg levodopa; Sinemet CR) with standard Sinemet 25/100 (Sinemet STD). The study design involved an 8-week open-label titration (dose-finding) phase (STD and CR preparations given individually during weeks 1–4 and 5–8 respectively) followed by a 24-week double-blind, double-dummy (placebo) treatment period. Drug efficacy was assessed using: (a) data from patients' diaries (i.e. “on-off” periods) (b) the functional disability profile (Northwestern University Disability Scale), (c) the neurological signs and symptoms (New York University Parkinson's Disease Scale, NYUPDS), (d) global evaluations made by the patient and treating physician and (e) the patient's evaluation of sleep. The results indicate that the number of “off” periods and the total NYUPDS score decreased significantly in the patients treated with Sinemet CR compared with those treated with Sinemet STD. Furthermore, the patient's global evaluation was significantly better in the Sinemet CR group. The number of drug-related adverse experiences was similar in the two groups, and only one serious event of this nature was reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00868520
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Increased angiotensin-converting enzyme activity in cerebrospinal fluid of treated patients with Parkinson's disease
    Amsterdam : Elsevier
    Clinica Chimica Acta 231 (1994), S. 101-106 
    Details
    ISSN: 0009-8981
    Keywords: Angiotensin-converting enzyme ; Cerebrospinal fluid ; Dopaminergic treatment ; Parkinson's disease
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(94)90259-3
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Serum α1-antichymotrypsin is not a useful marker for Alzheimer's disease or dementia in Parkinson's disease (1993)
    Springer
    Journal of neural transmission 6 (1993), S. 145-149 
    Details
    ISSN: 1435-1463
    Keywords: α1-Antichymotrypsin ; neurodegeneration ; Alzheimer's disease ; Parkinson's disease ; dementia ; multiple system atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured serum α1-antichymotrypsin (ACT) levels in patients with Alzheimer's disease (AD), Parkinson's disease (PD), Multiple System Atrophy (MSA) and age-matched controls to evaluate whether serum ACT levels in AD patients were elevated and whether ACT levels in PD patients with dementia differed from those in PD or AD. None of the patient groups displayed an increase in ACT levels. We conclude that serum ACT is not useful as a marker, nor in AD nor in dementia in PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261008
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy (1994)
    Springer
    Journal of neural transmission 7 (1994), S. 109-114 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; Alzheimer's disease ; multiple system atrophy ; aging ; cerebrospinal fluid ; iron ; ferritin ; oxidative stress ; free radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Iron is believed to play a role in the pathogenesis of both Parkinson's disease (PD) and Alzheimer's disease (AD). We measured ferritin, which is considered to be the iron storage protein, in CSF of patients with PD, AD, and multiple system atrophy (MSA) as well as control subjects. We found a significant increase in CSF ferritin in AD compared with both PD and age-matched controls. No significant differences were found between PD patients with dementia (PDD) and non-demented PD patients. For non-demented PD patients a positive correlation between CSF ferritin and age was found. Our results may indicate that iron has a role in the pathophysiology of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260965
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Carbon and nitrogen relationships in the microbial biomass of soils in beech (Fagus sylvatica L.) forests (1995)
    Springer
    Biology and fertility of soils 19 (1995), S. 141-147 
    Details
    ISSN: 1432-0789
    Keywords: Microbial biomass ; Biomass C:N ratio Acidification ; Beech forest ; Soil organic C ; Total N
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Soils from 38 German forest sites, dominated by beech trees (Fagus sylvatica L.) were sampled to a depth of about 10 cm after careful removal of overlying organic layers. Microbial biomass N and C were measured by fumigation-extraction. The pH of the soils varied between 3.5 and 8.3, covering a wide range of cation exchange capacity, organic C, total N, and soil C:N values. Maximum biomass C and biomass N contents were 2116 μg C m-2 and 347 μg N m-2, while minimum contents were 317 and 30 μg m-2, respectively. Microbial biomass N and C were closely correlated. Large variations in microbial biomass C:N ratios were observed (between 5.4 and 17.3, mean 7.7), indicating that no simple relationship exists between these two parameters. The frequency distribution of the parameters for C and N availability to the microflora divided the soils into two subgroups (with the exception of one soil): (1) microbial: organic C〉12 mg g-1, microbial:total N〉28 mg g-1 (n=23), a group with high C and N availability, and (2) microbial:organic C≤12 mg g-1, microbial:total N≦28 mg g-1 (n=14), a group with low C and N availability. With the exception of a periodically waterlogged soil, the pH of all soils belonging to subgroup 2 was below 5.0 and the soil C:N ratios were comparatively high. Within these two subgroups no significant correlation between the microbial C:N ratio and soil pH or any other parameter measured was found. The data suggest that above a certain threshold (pH 5.0) microbial C:N values vary within a very small range over a wide range of pH values. Below this threshold, in contrast, the range of microbial C:N values becomes very large.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336150
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Microbial biomass phosphorus in soils of beech (Fagus sylvatica L.) forests (1995)
    Springer
    Biology and fertility of soils 19 (1995), S. 215-219 
    Details
    ISSN: 1432-0789
    Keywords: Microbial biomass ; Acidification ; Beech forest ; Soil organic C ; Total P ; Fagus sylvatica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Thirty-eight soils from forest sites in central Germany dominated by beech trees (Fagus sylvatica L.) were sampled to a depth of about 10 cm after careful removal of the overlying organic layers. Microbial biomass P was estimated by the fumigation — extraction method, measuring the increase in NaHCO3-extractable phosphate. The size of the microbial P pool varied between 17.7 and 174.3 μg P g-1 soil and was on average more than seven times larger than NaHCO3-extractable phosphate. Microbial P was positively correlated with soil organic C and total P, reflecting the importance of soil organic matter as a P source. The mean microbial P concentration was 13.1% of total P, varying in most soils between 6 and 18. Microbial P and microbial C were significantly correlated with each other and had a mean ratio of 14.3. A wide (5.1–26.3) microbial C: P ratio indicates that there is no simple relatinship between these two parameters. The microbial C: P ratio showed strong and positive correlations with soil pH and cation exchange capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336162
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of acid rain on leaf-litter decomposition in a beech forest on calcareous soil (1991)
    Springer
    Biology and fertility of soils 11 (1991), S. 151-156 
    Details
    ISSN: 1432-0789
    Keywords: Acid rain ; Mesofauna ; Decomposition ; Beech forest ; Calcareous soil ; Litterbag ; 14C-labelled beech leaf litter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The effects of simulated acid rain on litter decomposition in a calcareous soil (pHH 2 O 5.8) were studied. Litterbags (45 μm and 1 mm mesh size) containing freshly fallen beech leaf litter were exposed to different concentrations of acid in a beech forest on limestone (Göttinger Wald. Germany) for 1 year. Loss of C, the ash content, and CO2−C production were measured at the end of the experiment. Further tests measured the ability of the litter-colonizing microflora to metabolize 14C-labelled beech leaf litter and hyphae. The simulated acid rain strongly reduced CO2−C and 14CO2−C production in the litter. This depression in production was very strong when the input of protons was 1.5 times greater than the normal acid deposition, but comparatively low when the input was 32 times greater. acid deposition may thus cause a very strong accumulation of primary and secondary C compounds in the litter layer of base-rich soils, even with a moderate increase in proton input. The presence of mesofauna significantly reduced the ability of the acid rain to inhibit C mineralization. The ash content to the 1-mm litterbags indicated that this was largely due to transport of base-rich mineral soil into the litter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336381
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of mesofauna exclusion on the microbial biomass in two moder profiles (1992)
    Springer
    Biology and fertility of soils 12 (1992), S. 253-260 
    Details
    ISSN: 1432-0789
    Keywords: Mesofauna ; Microbial biomass ; Litterbag ; Beech forest ; Moder ; Lime
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary In December 1988, litterbags (mesh size 45 or 1000 μm) were exposed in the organic layer of a limed and unlimed moder soil under beech forest in the Solling area (Germany). At both sites, substrata from the L1, L2, F1, F2 and from the H Layer were sampled shortly before the beginning of the experiment, defaunated, filled separately into litterbags and replaced in the respective horizons in the field. Litterbags were retrieved on three sampling dates (May, September, and November 1989). The soil microbial biomass was estimated by means of the fumigation extraction method. The results show that the effects of excluding mesofauna from the 45-μm litterbags were different in different horizons, on different sampling dates and in different study sites. Calculation of the “average” effect from the three sampling dates revealed that mesofauna exclusion reduced the microbial biomass C at both sites. It was concluded from horizon- and season-specific differences between the two litterbag treatments that a depression in microbial biomass C in the organic layer of a moder soil by mesofaunal grazers is confined to situations where environmental conditions cause strong feeding pressure and when the microflora is exposed to environmental stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336040
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Hexosamines in the organic layer of two beech forest soils: effects of mesofauna exclusion (1993)
    Springer
    Biology and fertility of soils 15 (1993), S. 301-307 
    Details
    ISSN: 1432-0789
    Keywords: Mesofauna ; Amino sugar ; Soil micro-flora ; Beech forest ; Moder ; Lime
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary In December 1988, litter bags (mesh size: 45 and 1000 μm) were exposed in the organic layer of unlimed and limed moder soil under beech forest in the Solling area of Germany. Bags were retrieved on three sampling dates (May, September, and November 1989) and amounts (g m-2) of glucosamine and galactosamine were determined. Horizon-specific differences generally explained by far the largest part of the treatment variance. In the substrate sampled in December 1988 from the unlimed area glucosamine increased by a factor of 11.8 from the L 1 layer to the H layer and galactosamine by a factor of 15.9. With the exception of the F2 layer, the hexosamine amounts found in the limed substrate sampled in December 1988 were higher in all horizons than in the corresponding horizons sampled from the unlimed area. Exclusion of mesofauna from the 45-μm litter bags generally reduced the level of amino sugars at both sites. The difference between the two mesh sizes was most pronounced in the lowermost horizons (F2 and H) and quite small in the upper horizons. The exclusion of mesofauna significantly increased the glucosamine: galactosamine ratio in the two L layers of the unlimed soil on all sampling dates. Seasonal fluctuations suggested that the actual amino sugar content of the organic layer was essentially the function of two components, the first reflecting long-term accumulation of microbial metabo-lites, and the second reflecting short term fluctuations in the microbial colonization of various C sources together with spatial and temporal differences in the ability of the microflora to produce and to decompose hexosamines. The results of this study show that the mesofauna in the beech forest soils investigated significantly affected both the amino sugar components measured, and thus stimulated the accumulation of one of the most important N pools in forest soils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337217
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Practical benefit of [123I]FP-CIT SPET in the demonstration of the dopaminergic deficit in Parkinson's disease (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 68-71 
    Details
    ISSN: 1619-7089
    Keywords: Parkinson's disease ; Single-photon emission tomography ; Dopamine transporter imaging ; Cocaine analogues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Loss of striatal dopamine (DA) transporters in Parkinson's disease (PD) has been accurately assessed in vivo by single-photon emission tomography (SPET) studies using [123I]β-CIT. However, these studies have also shown that adequate imaging of the striatal DA transporter content can be performed only 20–30 h following the injection of [123I]β-CIT, which is not convenient for routine out-patient evaluations. Recently, a new ligand,N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)tropane (FP-CIT), became available for in vivo imaging of the DA transporter. The faster kinetics of [123I]FP-CIT have been shown to allow adequate acquisition as early as 3 h following injection. In the present study, loss of striatal DA transporters in five non-medicated PD patients was assessed on two consecutive SPET scans, one with [123I]β-CIT (24 h following injection) and one with [123I]FP-CIT (3 h following injection). The ratios of specific to non-specific [123I]FP-CIT uptake in the caudate nucleus and putamen were consistently 2.5-fold lower than those of [123I]β-CIT. However, when the uptake ratio of both ligands in these brain regions of patients was expressed as a percentage of the uptake ratio found in healthy controls, both the decrease and the variation of the data were similar. It is concluded on the basis of these findings that [123I]FP-CIT seems as good as [123I]β-CIT for the assessment of the dopaminergic deficit in PD. The faster kinetics of [123I]FP-CIT are a clear advantage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728311
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    Paper (German National Licenses)
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