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  • Articles: DFG German National Licenses  (2)
  • Benzodiazepines  (1)
  • CB 154  (1)
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  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 47 (1976), S. 101-103 
    ISSN: 1432-2072
    Keywords: Food-intake ; Benzodiazepines ; Appetite
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten, and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less potent than the benzodiazepines tested.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 300 (1977), S. 239-245 
    ISSN: 1432-1912
    Keywords: Bromocriptine ; CB 154 ; Dopamine metabolism ; Motility ; Sedation ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bromocriptine, an ergot-derivate with DA-receptor stimulating properties in vivo, produces long-lasting hypomotility in mice not accustomed to the motility cage and decreases brain DOPAC and HVA without affecting brain DA. These effects are obtained with doses 25 times lower than those which produce hypermotility. The decrease of brain DOPAC is correlated to the hypomotility both on a dose- and on a time-basis. Potent neuroleptics as pimozide, benzperidol and droperidol, which are considered to be fairly specific DA-receptor blockers, antagonize the hypomotility and the decrease of brain DOPAC produced by bromocriptine. These effects are obtained with very low doses (0.05–0.3 mg/kg) of neuroleptics which per se do not affect motility or brain DOPAC. The maximal decrease of brain DOPAC and HVA produced by bromocriptine is similar to that produced by apomorphine and the combination of these drugs does not result in a further decrease of brain DOPAC or HVA. On the basis of these results it is postulated that bromocriptine decreases brain DA-turnover and produces hypomotility by acting on “regulatory” DA-receptors different from the post-synaptic ones of the “terminal” dopaminergic areas.
    Type of Medium: Electronic Resource
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