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  • Articles: DFG German National Licenses  (2)
  • Bilirubin ¶encephalopathy  (1)
  • partial structure factors  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Expression of the α and β subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 393-401 
    Details
    ISSN: 1432-0533
    Keywords: Key words Hyperbilirubinemia ; Bilirubin ¶encephalopathy ; Kernicterus ; Cerebellum ; Purkinje cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The homozygous (jj) jaundiced Gunn rat model for hyperbilirubinemia displays pronounced cerebellar hypoplasia. To examine the cellular mechanisms involved in bilirubin toxicity, this study focused on the effect of hyperbilirubinemia on calcium/calmodulin-dependent kinase II (CaM kinase II). CaM kinase II is a neuronally enriched enzyme which performs several important functions. Immunohistochemical analysis of alternating serial sections were performed using monoclonal antibodies for the α and β subunits of CaM kinase II. Measurements were made of the total numbers of stained cells in each of the deep cerebellar nuclei and of Purkinje and granule cell densities in cerebellar lobules II, VI, and IX. The β subunit was present in Purkinje cells and deep cerebellar nuclei of both groups at all ages, but only granule cells which had migrated through the Purkinje cell layer showed staining for β subunit; external granule cells were completely negative. Many Purkinje cells had degenerated in the older animals, and the percent of granule cells stained for β subunit was significantly reduced. The α subunit was found exclusively in Purkinje cells, although its appearance was delayed in the jaundiced animals. Sulfadimethoxine was administered to some jj rats 24 h or ¶15 days prior to sacrifice to increase brain bilirubin concentration. Results showed that bilirubin exposure modulated both α and β CaM kinase II subunit expression in selective neuronal populations, but sulfadimethoxine had no acute effect on enzyme immunoreactivity. Thus, developmental expression of the α and β subunits of CaM kinase II was affected by chronic bilirubin exposure during early postnatal development of jaundiced Gunn rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051141
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Short-range order effects in amorphous polycondensates as studied by spin polarized diffuse neutron scattering and simulation (1994)
    Springer
    Colloid & polymer science 272 (1994), S. 1403-1419 
    Details
    ISSN: 1435-1536
    Keywords: Polycarbonate ; partial structure factors ; neutron scattering ; simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Short-range order effects in amorphous polycondensates, including the technologically important bisphenol-A-polycarbonate, have been investigated by elastic diffuse neutron scattering with spin polarization analysis. Selectively deuterated samples of each polycondensate have been used in order to vary the scattering contrast and thereby emphasize different pair correlations. The technique of spin polarization analysis allowed a reliable separation of the coherent scattering and an intensity calibration on the basis of the incoherent scattering as an internal standard. Thus, (dσ/dΩ)coh has been measured directly by this method. The experimental results are compared to calculated cross-sections from computer-generated structures. Simulations have been performed with the “amorphous cell” method which models the static structure of the amorphous polymer in full chemical detail on the basis of a “random coil” conformation. The results of the simulations yield a fertily ground for the discussion of the measured cross-sections, though a direct comparison with the experiment is not always satisfactory. The observed discrepancies indicate a still insufficient structural relaxation of the simulated structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00654171
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    Paper (German National Licenses)
    Fulltext
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