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  • Articles: DFG German National Licenses  (6)
  • Bladder cancer  (2)
  • Tandemly repeated DNA sequence  (2)
  • state feedback  (2)
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  • Articles: DFG German National Licenses  (6)
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Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition by Vitamin C of DNA adduct formation and arylamine N-acetyltransferase activity in human bladder tumor cells (2000)
    Springer
    Urological research 28 (2000), S. 235-240 
    Details
    ISSN: 1434-0879
    Keywords: Key words Vitamin C ; N-acetyltransferase ; 2-aminofluorene ; DNA adduct ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have already demonstrated the protective role of vitamin C (ascorbic acid) in certain types of cancer. This study reports on the effects of vitamin C on arylamineN-acetyltransferase (NAT) activity and DNA adduct formation in a human bladder tumor cell (T24) line. The activity of NAT was measured using high-performance liquid chromatography (HPLC), by assaying for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and the remaining amounts of AF and PABA. T24 cells were used for examining NAT activity and carcinogen–DNA adduct formation. The results demonstrated that NAT activity and 2-aminofluorene–DNA adduct formation in T24 cells were inhibited and decreased by vitamin C in a dose-dependent manner. The apparent kinetic parameters (apparent values ofK m and V max) from T24 cells were also determined with and without vitamin C cotreatment. The data also indicated that vitamin C decreased the apparent values of K m and V max from T24 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002400000130
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Distributions of p53 codon 72 polymorphism in bladder cancer – proline form is prominent in invasive tumor (2000)
    Springer
    Urological research 28 (2000), S. 293-296 
    Details
    ISSN: 1434-0879
    Keywords: Key words p53 codon 72 polymorphism ; Bladder cancer ; Proline form ; Arginine form
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abnormal function of p53 is commonly associated with various cancer formations. High-grade and late-stage bladder cancers have been reported to have mutated or become inactive p53 when using immunohistochemical stains. Recently, p53 codon 72 polymorphism was extensively studied to determine the risk factors responsible for cancer formation. There was a general population of codon 72 sequence polymorphism of the wild type p53. A single base change from G to C caused the alteration of amino acid residue 72 from arginine to proline. The arginine form is considered to be a significant risk factor in the development of cancer. However, various reports had indicated discrepancies with regard to this polymorphism; some showed no significant difference between the control and cancer groups, while other series were associated with high risks in the proline form homozygotes. To resolve the undefined distribution of this polymorphism in bladder cancers, 58 patients with bladder cancer were enrolled onto this study. When checked using the Chi-squared test (P=0.952) there were no differences between the control subjects and bladder cancer patients in the distribution of polymorphism. However, proline form homozygotes were more frequently found in the invasive group than the non-invasive group by Fisher's exact test (25% and 2.9%, respectively, P 〈 0.001). More than 70% of the non-invasive bladder cancers were the arginine form homozygotes. This result is consistent with those reported for hepatocellular carcinoma that showed a history of chronic liver disease and proline form homozygotes in a report by Yu et al. Our data suggest that proline form homozygotes are associated with invasive bladder cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002400000117
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Isolation and identification of a non-specific tandemly repeated DNA sequence in Oryza species (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 702-708 
    Details
    ISSN: 1432-2242
    Keywords: Oryza ; Tandemly repeated DNA sequence ; Restriction fragment length polymorphism (RFLP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A tandemly repeated DNA sequence (RRS7) was isolated from Oryza alta (CCDD). RRS7-related sequences were also found tandemly arrayed in genomes AA, BB, BBCC, CC, and EE, and a small amount of RRS7-related sequences were detected in genome FF and the Oryza species with unknown genomes. DNA sequence analysis of the 1844-bp insert of RRS7 revealed that it contained six tandemly repeated units, of which five were 155 bp in length and one was 194 bp in length and contained an imperfect internal 39-bp duplication. Southern blot analysis showed that the boundary sequence contained in RRS7 is a single-copy sequence. A 155-bp consensus sequence derived from the six monomeric repeats contained no internal repeat and showed no significant homology to other currently known sequences. The results of Southern blot and sequence analysis revealed that there are at least two subfamilies present in the RRS7 family; these are represented by the DraI site and the MspI site, respectively. Restriction digestion with two pairs of isoschizomers MboI/Sau3A and MspI/HpaII demonstrated that most of the C residues in the GATC sites and the internal C in the CCGG sites of the RRS7 family in O. Alta were methylated. The usefulness of the RRS7 family in determining the evolutionary relationship of the genome DD and other Oryza genomes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226092
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Isolation and identification of a non-specific tandemly repeated DNA sequence in Oryza species (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 702-708 
    Details
    ISSN: 1432-2242
    Keywords: Key words Oryza ; Tandemly repeated DNA sequence ; Restriction fragment length polymorphism (RFLP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A tandemly repeated DNA sequence (RRS7) was isolated from Oryza alta (CCDD). RRS7-related sequences were also found tandemly arrayed in genomes AA, BB, BBCC, CC, and EE, and a small amount of RRS7-related sequences were detected in genome FF and the Oryza species with unknown genomes. DNA sequence analysis of the 1844-bp insert of RRS7 revealed that it contained six tandemly repeated units, of which five were 155 bp in length and one was 194 bp in length and contained an imperfect internal 39-bp duplication. Southern blot analysis showed that the boundary sequence contained in RRS7 is a single-copy sequence. A 155-bp consensus sequence derived from the six monomeric repeats contained no internal repeat and showed no significant homology to other currently known sequences. The results of Southern blot and sequence analysis revealed that there are at least two subfamilies present in the RRS7 family; these are represented by the DraI site and the MspI site, respectively. Restriction digestion with two pairs of isoschizomers MboI/Sau3A and MspI/HpaII demonstrated that most of the C residues in the GATC sites and the internal C in the CCGG sites of the RRS7 family in O. alta were methylated. The usefulness of the RRS7 family in determining the evolutionary relationship of the genome DD and other Oryza genomes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050182
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Robust Tracking and Model Following Control with Zero Tracking Error for Uncertain Dynamical Systems (2000)
    Springer
    Journal of optimization theory and applications 107 (2000), S. 169-182 
    Details
    ISSN: 1573-2878
    Keywords: state feedback ; robust tracking control ; model following control ; uncertain systems ; asymptotic tracking ; practical tracking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of robust tracking and model following for a class of linear dynamical systems with time-varying uncertain parameters and disturbances is considered. A class of continuous (nonlinear) state feedback controllers is proposed for robust tracking of dynamical signals. The proposed robust tracking controllers can guarantee that the tracking error decreases asymptotically to zero in the presence of uncertain parameters and disturbances. A procedure for designing such a zero tracking state feedback controller is also introduced. Finally, a numerical example is given to demonstrate the validity of the results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004665018593
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Decentralized robust control for a class of uncertain large-scale interconnected nonlinear dynamical systems (1996)
    Springer
    Journal of optimization theory and applications 91 (1996), S. 235-256 
    Details
    ISSN: 1573-2878
    Keywords: Large-scale interconnected systems ; decentralized control ; robust control ; uncertainties ; state feedback ; sufficient conditions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of the decentralized robust control for a class of large-scale interconnected nonlinear dynamical systems with input interconnection and external interconnection perturbations is considered. Based on the stabilizability of each nominal isolated subsystem (i.e., the isolated subsystem in the absence of interconnection perturbations), a class of decentralized local state feedback controllers is proposed, and some sufficient conditions are derived by making use of the Lyapunov stability criterion such that uncertain large-scale interconnected systems can be stabilized asymptotically by these decentralized state feedback controllers. For large-scale systems with only input interconnection perturbations, such decentralized controllers become a class of decentralized stabilizing state feedback controllers. That is, the decentralized stability of such large-scale systems can be guaranteed always by using the decentralized state feedback controllers proposed in the paper. Finally, a numerical example is given to demonstrate the validity of the results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02192291
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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