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  • Articles: DFG German National Licenses  (2)
  • Breast cancer  (1)
  • Liver function  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 249-252 
    ISSN: 1432-1335
    Keywords: Breast cancer ; c-erbB-2 oncogene ; ICA ; p185 fragment ; Serum determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concentrations of a fragment of the c-erbB-2 translational product (p185 fragment) were measured in serum of 70 breast cancer patients, 19 healthy blood donors, and 18 pregnant women using a heterogenic enzyme immunoassay. The serum concentrations of blood donors and pregnant women were below 30 kU/l. Breast cancer patients showed serum concentrations up to 578 kU/l. All 9/70 patients with serum concentrations higher than 30 kU/l had clinical evidence of metastatic disease and the serum levels of all 35/70 patients without metastasis lay within the normal range. From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l. In all, 6/9 patients without metastasis serum levels were below 30 kU/l. The data of the present study suggest that determination of serum p185 fragment concentrations may be useful as a diagnostic tool in postoperative follow-up of breast cancer patients with c-erbB-2 overexpression of the primary tumor.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Portal blood supply ; Liver function ; Portocaval shunt ; Arterialization of a portocaval shunt ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand eines tierexperimentellen Modells werden die Folgen operativ veränderter Perfusionsbedingungen auf die Leberfunktion aufgezeigt. Drei Gruppen mit je 5 Versuchstieren (deutsches Hausschwein) werden folgenden Operationen unterzogen: Gruppe 1 erhielt einen portokavalen Shunt. Zusätzlich zu einem portokavalen Shunt wurde Gruppe 2 mit einem venösen Interponat zwischen V cava und Pfortaderstumpf versehen. Bei den Tieren der Gruppe 3 wurde neben den beiden genannten Operationen noch eine Arterialisation des Interponats durchgeführt. Im Verlauf wurden zu definierten Zeitpunkten klinische, laborchemische und histologische Daten erfaßt. Die Tiere der Gruppen 2 und 3 wiesen im Verhalten and ebenfalls hinsichtlich aller erhobener Leberfunktionsparameter normale Werte auf. Die Tiere der Gruppe 1 zeigten in allen genannten Funktionen erheblich schlechtere Ergebnisse. In dieser Arbeit konnte demonstriert werden, daß fur eine normale Leberfunktion die direkte portale Perfusion entbehrlich ist und letztere durch kavalvenöses bzw. arterialisiertes kavalvenoses Blut voll kompensiert werden kann.
    Notes: Summary Using an experimental animal model consequences of operatively changed modes of liver perfusion on hepatic function could be demonstrated. Three groups of 5 animals each (swine) had the following operations: Group I received a portocaval shunt. In group II in addition to the portocaval shunt a vein graft was interposed between the vena cava and the portal vein. In group III an arterialization of this graft was performed in addition to the two operations mentioned above. Follow-up at defined time intervals included clinical, laboratory and histological data. It could be demonstrated that animals in group II and III showed normal parameters as far as behavior and controlled lab data are concerned. Animals of group I had significantly poorer results in all tests. In this study we found that direct portal perfusion was not necessary for a normal liver function and could be fully compensated both by caval venous blood and by arterialized caval venous blood.
    Type of Medium: Electronic Resource
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