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  • Articles: DFG German National Licenses  (2)
  • CTG expansion  (1)
  • Cost analysis  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Long-term cyclosporine treatment in a group of severe myasthenia gravis patients (1997)
    Springer
    Journal of neurology 244 (1997), S. 542-547 
    Details
    ISSN: 1432-1459
    Keywords: Key words Myasthenia gravis ; Cyclosporine ; Immunosuppressive therapy ; Corticosteroids ; Cost analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated cyclosporine A (CsA) treatment in 9 patients (6 female and 3 male), 16–63 years old, with severe myasthenia gravis (MG) for a mean period of 2 years (range 16–36 months). All of the patients had been previously treated either with corticosteroids or by combined immunotherapy, and 5 needed periodic plasma exchanges. The reduction of plasmapheresis cycles in the 5 patients who needed periodic plasma exchange to mantain an acceptable quality of life showed an impressive cost-benefit analysis. During CsA treatment 7 of 9 patients improved their muscle strength and functional score. In all the patients except one the corticosteroid dosage was reduced and in 7 of the 9 patients the dose reduction was over 50% with subsequent reduction of the corticosteroid side effects. The findings showed that initiation of CsA treatment increased muscle strength and reduced corticosteroid dosage. The most common CsA side effects were: a serum creatinine increase that occurred in the first 6– 12 months of therapy in 8 patients, other side effects like hypertrichosis and gingival hyperplasia were present in four patients. Blood pressure increase was found in only one patient. CsA treatment may be a valuable and cost effective treatment in severe MG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050141
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Positive correlation of CTG expansion and pharyngoesophageal alterations in myotonic dystrophy patients (1998)
    Springer
    Neurological sciences 19 (1998), S. 75-80 
    Details
    ISSN: 1590-3478
    Keywords: Myotonic dystrophy ; Pharyngoesophageal motility ; Videofluoroscopy ; CTG expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alteration of the pharyngoesophageal musculature is a common finding in patients with myotonic dystrophy (MD), regardless of the presence of dysphagia. The aim of the present study was to determine whether a specific pattern of swallowing abnormalities could be identified in MD patients, and the possible correlation with the size of CTG repeats. Fifteen MD patients, 8 of whom were asymptomatic for dysphagia, underwent a videofluoroscopic study of swallowing. Alterations of the pharyngoesophageal phase of swallowing were detected in 12 of 15 patients, 6 without clinical evidence of dysphagia. Incomplete relaxation of the upper esophageal sphincter (UES) and esophageal hypotonia were the most common alterations. We found a significant correlation between the number of radiological alterations and the size of CTG repeats. A typical radiological pattern of swallowing has also been identified. The role of videofluoroscopy in evaluation of MD patients is briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427560
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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