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  • Articles: DFG German National Licenses  (3)
  • Conflict behavior  (2)
  • Caffeine  (1)
  • Memory retrieval  (1)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Role of serotonin in memory: facilitation by alaproclate and zimeldine (1984)
    Springer
    Psychopharmacology 84 (1984), S. 496-502 
    Details
    ISSN: 1432-2072
    Keywords: Alaproclate ; Zimeldine ; Memory retrieval ; Passive avoidance ; Serotonin ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of alaproclate and zimeldine on memory retrieval were examined in male Swiss Webster mice using a one-trial inhibitory avoidance task. All drugs were administered IP prior to the retention test 24 h after training. Both drugs were found to facilitate memory retrieval significantly in a dose-and time-dependent fashion that could not be explained in terms of non-specific effects of the drug (illness, lack of motility, etc.) at the time of the test. The temporal effects of alaproclate and zimeldine on memory closely followed their course of concentration of the drug within the blood stream. The facilitation of retrieval induced by alaproclate and zimeldine was blocked by the putative serotonergic receptor agonist quipazine but not blocked by the antagonist cyproheptadine. Pretreatment with quipazine alone in a group of animals trained to a shock level which normally results in high levels of suppression was not sufficient to produce memory impairment, suggesting that quipazine was probably antagonizing the facilitative effects of alaproclate and zimeldine directly, rather than overriding the facilitation through an indirect action on retrieval in general. The present results lend further support to the suggestion that serotonin plays a significant role in memory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431456
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antagonism of the anti-conflict effects of phenobarbital, but not diazepam, by the A-1 adenosine agonistl-PIA (1990)
    Springer
    Psychopharmacology 102 (1990), S. 283-290 
    Details
    ISSN: 1432-2072
    Keywords: Adenosine ; Anxiety ; Conflict behavior ; Caffeine ; Conditioned Suppression of Drinking (CSD) ; Diazepam ; l-PIA ; NECA ; Phenobarbital ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study examined the effects of the anxiolytics diazepam and phenobarbital, the A-1 adenosine agonist N6-R-phenylisopropyladenosine (l-PIA), and the A-2 adenosine agonist 5′-N-ethylcarboxamidoadenosine (NECA) on conflict behavior. Water-restricted rats were trained to drink from a tube that was electrified (0.5 mA intensity) on a FI-29s schedule, electrification being signaled by a tone. After 3 weeks of daily 10-min sessions, the animals accepted a stable number of shocks (punished responding) and consumed a consistent volume of water (unpunished responding) per session. Different doses ofl-PIA and NECA were then tested separately at weekly intervals. In addition, the effects of diazepam and phenobarbital were determined in animals pretreated with saline,l-PIA, or NECA. Neitherl-PIA (15–250 nmole/kg) nor NECA (2.5–20 nmole/kg) produced a significant anti-conflict effect when administered alone. Diazepam (1.25–10 mg/kg) or phenobarbital (10–40 mg/kg) administration to saline-pretreated rats resulted in a dose-dependent increase in punished responding (shocks received) with minimal effects on unpunished responding (water intake). Neitherl-PIA nor NECA pretreatment reliably altered the effects of diazepam on conflict behavior. Pretreatment withl-PIA, but not NECA, significantly reduced the anti-conflict effects of phenobarbital on conflict behavior. These data suggest that phenobarbital, but not diazepam, anti-conflict responses may involve interactions with A-1 adenosine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244091
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Benzodiazepine anti-conflict effects in maudsley reactive (MR/Har) and non-reactive (MNRA/Har) rats (1990)
    Springer
    Psychopharmacology 100 (1990), S. 287-292 
    Details
    ISSN: 1432-2072
    Keywords: MR/Har and MNRA/Har Maudsley rat strains ; Conflict behavior ; Anxiety ; Alprazolam ; Diazepam ; Benzodiazepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Maudsley Reactive (MR/Har) and Non-Reactive (MNRA/Har) rat strains, bred originally by Broadhurst for differences in Open Field Defecation, also differ in their control (i.e., non-drug) behavior in the Conditioned Suppression of Drinking (CSD) conflict procedure, a second “model” behavior for the study of anxiety and/or emotionality in rats. The present studies compared the effects of diazepam and alprazolam on CSD behavior in these two strains of rats. In daily 10-min sessions, water-deprived rats were trained to drink from a tube that was occasionally electrified (0.2–0.5 mA), electrification being signaled by a tone. Both diazepam and alprazolam increased punished responding in a dose-related manner. The per cent increase in punished responding (for diazepam only) was comparable in the two strains; however, both statistical and empirical approaches indicated that the magnitude of the anti-conflict effect of benzodiazepines in MNRA/Har versus MR/Har rats was not related to differences in baseline (i.e., non-drug) punished responding. Based on the absolute change in shocks received, rats of the MNRA/Har strain exhibited a significantly greater anti-conflict effect following diazepam or alprazolam treatment than did rats of the MR/Har strain. These findings further the hypothesis that the behavioral differences exhibited by Maudsley MR/Har and MNRA/Har rat strains may constitute a genetically-based “animal model” for the study of emotionality and/or anxiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244595
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    Paper (German National Licenses)
    Fulltext
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