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  • Articles: DFG German National Licenses  (3)
  • Central nervous system  (1)
  • Paired helical filaments  (1)
  • soil respiration  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Key words Basal lamina ; Blood-brain barrier ; Central nervous system ; Congenital muscular dystrophy ; Laminin α2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, a rare form of congenital muscular dystrophy has been shown to be associated with a deficiency of laminin α2 chain, a tissue-specific component of the basal lamina. Besides muscular dystrophy, children affected with this disorder also show electrophysiological and magnetic resonance imaging evidence of white matter involvement in the central nervous system (CNS). We have studied the precise localization of laminin α2 chain in normal human brain, using specific electron microscopic techniques including thin-section fracture labeling and cryoultramicrotomy, in parallel with immunohistochemical techniques. We found that this laminin chain was localized to the basal lamina of all cerebral blood vessels, whereas blood vessels of the choroid plexus did not show any reaction. No positive reaction was found in meningeal blood vessels either. We hypothesize that in normal brain, laminin α2 may be important for the selective filtration capability of the blood-brain barrier. The lack of laminin α2 in cerebral vessels of children with laminin α2-deficient congenital muscular dystrophy may cause impaired selective filtration, leading to leakage of plasma components and damage to the CNS. Further studies should be performed on patients affected by congenital muscular dystrophy associated with laminin α2 deficiency to test this hypothesis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Microtubule-associated protein-2 ; Somatodendritic distribution ; Alzheimer's disease ; Senile plaque neurites ; Paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have developed monoclonal antibodies that detect normal microtubule-associated protein-2 (MAP2) epitopes in routinely fixed, paraffin-embedded tissue. The somatodendritic distribution of MAP2 in bovine and human nervous tissue was confirmed with several of these antibodies. Furthermore, some of these antibodies immunohistochemically labeled certain pathological structures in Alzheimer brain, especially neurites in senile plaques. Electron microscopic observations, however, indicate that these MAP2 epitopes are not located in the Alzheimer paired helical filaments themselves, but in amorphous granular structures coexistent with them. While the pathological nature of these structures is undetermined, they may represent artefactual modifications of normal cytoskeletal components.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Biogeochemistry 48 (2000), S. 147-163 
    ISSN: 1573-515X
    Keywords: carbon sequestration ; crop rotation ; greenhouse gas mitigation ; no-till ; soil organic matter ; soil respiration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Crop-based agriculture occupies 1.7 billion hectares, globally, with a soil C stock of about 170 Pg. Of the past anthropogenic CO2 additions to the atmosphere, about 50 Pg C came from the loss of soil organic matter (SOM) in cultivated soils. Improved management practices, however, can rebuild C stocks in agricultural soils and help mitigate CO2 emissions. Increasing soil C stocks requires increasing C inputs and/or reducing soil heterotrophic respiration. Management options that contribute to reduced soil respiration include reduced tillage practices (especially no-till) and increased cropping intensity. Physical disturbance associated with intensive soil tillage increases the turnover of soil aggregates and accelerates the decomposition of aggregate-associated SOM. No-till increases aggregate stability and promotes the formation of recalcitrant SOM fractions within stabilized micro- and macroaggregate structures. Experiments using13 C natural abundance show up to a two-fold increase in mean residence time of SOM under no-till vs intensive tillage. Greater cropping intensity, i.e., by reducing the frequency of bare fallow in crop rotations and increasing the use of perennial vegetation, can increase water and nutrient use efficiency by plants, thereby increasing C inputs to soil and reducing organic matter decomposition rates. Management and policies to sequester C in soils need to consider that: soils have a finite capacity to store C, gains in soil C can be reversed if proper management is not maintained, and fossil fuel inputs for different management practices need to be factored into a total agricultural CO2 balance.
    Type of Medium: Electronic Resource
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