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  • Articles: DFG German National Licenses  (12)
  • Chemistry  (10)
  • Enzyme Induction  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Hydroxylierung von Progesteron durch Lebermikrosomen von Kaninchen (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 265-277 
    Details
    ISSN: 1432-1912
    Keywords: Enzyme Induction ; Microsomal Hydroxylases ; Cytochrome P-450 ; Progesterone Metabolism ; Enzyminduktion ; Mikrosomale Hydroxylasen ; Cytochrom P-450 ; Progesteron-Stoffwechsel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The transformation of progesterone into four more polar metabolites was investigated using liver microsomes from untreated as well as phenobarbitaltreated rabbits. The formation of the four metabolites was dependent on oxygen and NADPH. The reactions were inhibited by CO and this inhibition by CO was partially reversible by light. The four reactions had the same pH-optimum at 7.4. The metabolite pattern was not changed by reducing the oxygen pressure, by inhibiting the reactions with CO, by diminishing the CO effect by light, by variation of the pH value, by separating microsomes into smooth and rough membranes, or by increasing the specific enzyme activities by a factor of 1.5, as a result of treating the microsomes by freezing, thawing, and consecutive centrifugation or filtration on agarose gel. Phenobarbital-treatment of the animals increased the formation of the four metabolites to different degrees, i.e. 3, 1.4, 15, and 6 fold, respectively. Since this procedure was the only one which changed the metabolite pattern, this effect is easier to explain by effects of the phenobarbital-treatment on the rate-limiting steps of the four reactions than by the assumption of four different enzymes catalyzing the metabolism of progesterone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997097
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Qualitative Änderungen in Lebermikrosomen Phenobarbital-behandelter Kaninchen (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 307-326 
    Details
    ISSN: 1432-1912
    Keywords: Enzyme Induction ; Microsomal Enzymes ; Michaelis Constants ; Spectral Dissociation Constants ; Affinity for Oxygen and Carbon Monoxide ; Schlüsselwörter ; Enzyminduktion ; Mikrosomale Enzyme ; Michaelis-Konstanten ; Spektrale Dissoziationskonstanten ; Sauerstoff- und Kohlenmonoxid-AffinitÄt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phenobarbital treatment of rabbits was found to cause significant changes in some of the apparent Michaelis (K M) constants for p- and N-hydroxylation of aniline [reactions 1 and 2, resp.] and de-ethylation, p- and N-hydroxylation of N-ethylaniline [reactions 3,4, and 5, resp.], and in the spectral dissociation constants (K s) for aniline, N-ethylaniline and ethylisocyanide in isolated hepatic microsomes. The “critical” oxygen concentrations were increased in all reactions investigated. The distribution constants (K G) for CO, determined according to Warburg, decreased in the reactions 2, 3, and 4, and increased in reaction 1. Reaction 5 was not inhibited by CO in microsomes from untreated rabbits and was stimulated by CO after phenobarbital treatment of the animals. Depending on the reaction, theK M-values for aniline and N-ethylaniline were increased, decreased, or remained unchanged by the phenobarbital treatment of the animals. The most striking changes inK M-values were observed with the reactions 2 and 5 in which cytochrome P-450 is either not involved or is not a limiting factor. TheK s-value for ethylisocyanide measured after addition of dithionite to microsomes was increased. The correspondingK s-value measured without dithionite under aerobic conditions remained unchanged. TheK s value for aniline was decreased by the phenobarbital treatment of the animals. Using microsomes from untreated animals theK s value for N-ethylaniline could not be determined exactly. The order of magnitude of this value, however, was greater than that of the corresponding value from phenobarbital-treated animals. The observed alterations in affinity imply that induction by phenobarbital may be associated withqualitative as well as quantitative changes in the hepatic microsomal enzymes or membranes. The qualitative changes could be important for the accessibility of the reacting groups and/or substrate guiding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999545
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Im Körper gebrochene Knochenplatten  -  Schadenanalyse und Biomechanik (1977)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 8 (1977), S. 78-82 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Osteotomy Plates which Failed in Vino  -  Failure Examination and Biomechanics.Two fractured bone plates, which were used in a subtrochanteric osteotomy, have been examinated. The fatigue failure and additional fracture-characteristics are easily to understand in regarding the stresses, acting in the plates. An evaluation shows, that such a plate should never bear any part of the body weight but should be used only for fracture-fixation.
    Notes: Zwei gebrochene Knochenplatten, die zur Versorgung von subtrochanteren Oberschenkelbrüchen eingesetzt waren, wurden untersucht. Die festgestellten Dauerbrüche und weitere Einzelheiten der Schadensfälle lassen sich zwanglos durch die Art der Belastung der Platten im Körper erklären. Eine Abschätzung der Spannungen in den Platten zeigt, daß sie lediglich eine frakturstabilisierende Funktion übernehmen können und keinesfalls einer Belastung durch das Körpergewicht ausgesetzt werden dürfen.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19770080305
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Beiträge zur analytischen Chemie des Rheniums. 13. Über die Bestimmung des Chlors in Rheniumverbindungen (1937)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 234 (1937), S. 289-297 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Es wird gezeigt, daß die Bestimmung des Chlors neben Perrhenat durch Fällung mit AgNO3 möglich ist.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19372340402
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Histological and ultrastructural appearance of the hydroxyapatite-bone interface (1990)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 24 (1990), S. 829-845 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This article describes the histological and ultrastructural appearance of the interface created in the implantation bed, between bone tissue and implants made of dense sintered hydroxyapatite (HA). Biopsies from dog subjects included: (a) loaded permucosal dental implants for tooth substitution, (b) subperiosteally placed implants for alveolar bone correction, (c) endosseously placed dental root implants to retain ridge form following extraction. The light and electron microscopical results show extensive bone apposition on the osseous sides of the implant surfaces. There is an intimate, direct bone contact without any visible interruption. The bone is of normal lamellar type and continuously connected with the trabecular bone. Bone has grown into the finest surface irregularities of the implant. Collagen fibers of the calcified bone matrix are observed within a distance less than 500 Å from the implant surface. The thin (20-100 Å) electron dense layer at the bone-implant interface resembled the lamina limitans of organic bone matrix, also seen at the inner walls of the osteocytes lacunes. Deposition of bone gives rise to a biologically stable bone-implant interface, without disturbance of the physiological bone turnover. This is seen as very favorable for desired long term fixation of implant to bone.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820240704
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  • 6
    Electronic Resource
    Electronic Resource
    Reaktionen von Metallcarbonylen mit HalogenazidenProfessor J. Goubeau zum 65. Geburtstage am 31. März 1966 gewidmet (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 344 (1966), S. 167-178 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The reaction of Fe(CO)5 with ClN3 and BrN3 at -20° leads to the formation of Fe(CO)2N3X (X = Cl, Br). According to their magnetic behaviour and IR spectra these compounds have the structure [Fe(CO)2N3]22+ 2X-; 2 Fe and 2 N forming a practically planar four-membered Fe—N ring (pseudo D2h). By thermal decomposition the azide halides FeXN3 can be obtained. Mo(CO)6 and W(CO)6 react with ClN3 in CCl4 solution to give the carbonyl azides [M(CO)2ClN3]∞, being polymerized via Cl and N bridges.
    Notes: Fe(CO)5 reagiert mit ClN3 und BrN3 bei - 20° unter Bildung von Fe(CO)2N3X (X = Cl, Br), das nach dem magnetischen Verhalten und dem IR-Spektrum als[Fe(CO)2N3]22+2 X- aufzufassen ist, wobei 2 Fe und 2 N einen weitgehend planaren Fe-N-Vierring bilden (Pseudo-D2h). Durch thermischen Abbau entstehen die CO-freien Azidhalogenide FeXN3. Mo(CO)6 und W(CO)6 reagieren mit ClN3 in CCl4-Lösung zu den polymeren, Über Cl- und N-verbrückten Carbonylazidhalogeniden [M(CO)2ClN3]∞.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19663440307
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  • 7
    Electronic Resource
    Electronic Resource
    Über o-, m- und p-Toluolazo-α-naphtylhydrazin-sulfosäure (1920)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 101 (1920), S. 123-135 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19201010403
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  • 8
    Electronic Resource
    Electronic Resource
    Über o-, m- und p-Toluolazo-α-naphtylhydrazin-sulfosäure (1920)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 101 (1920), S. 123-135 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19201010110
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  • 9
    Electronic Resource
    Electronic Resource
    Über eine Sulfoniumsalzbildung bei der Addition von Mercaptocarbonsäuren an ungesättigte Säuren (1952)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 64 (1952), S. 224-224 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19520640807
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  • 10
    Electronic Resource
    Electronic Resource
    Some aspects of isobutane and ammonia chemical ionization for the analysis of volatile esters and phenylpropanoids occurring in essential oilsDedicated to Professor Dr H.-F. Grützmacher on the occasion of his 60th birthday. (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 27 (1992), S. 481-488 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The fragmentation reactions of some terpenoid esters and pbenylpropanoids under the conditions of isobutane and ammonia chemical ionization (CI) arc discussed. The esters show different behaviour with these two gases with respect to determination of the relative molecular mass and information about the structure of the molecules. The structural isomers of the phenylpropanoids can unequivocally be distinguished with both isobutane and ammonia CI. Cis/trans isomers of the phenylpropanoids show virtually identical CI spectra.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210270420
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