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Filipin-sterol complexes at Schmidt-Lanterman incisures (1987)

Blanchard, C. E. ; Sikri, K. ; Allt, G.

Springer

Acta neuropathologica 72 (1987), S. 355-361

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ISSN: 1432-0533

Keywords: Filipin ; Cholesterol ; Schmidt-Lanterman incisures ; Myelin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Employing the freeze-fracture technique, the distribution of filipin-sterol complexes was determined for membranes of peripheral nerve myelin. A heterogeneous distribution of complexes was observed with the greatest abundance on membranes associated with the cytoplasmic channels of Schmidt-Lanterman and longitudinal incisures. In addition there was an irregular network of well-labelled membrane bands in compact myelin. The results are related to a possible role for these channels and bands in the biochemical turnover of cholesterol in myelin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00687267

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