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Digitale Medien

Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging (1994)

Verheul, H. B. ; Tamminga, K. S. ; Dijkhuizen, R. M. ; [weitere]

Springer

Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 367-370

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ISSN: 1352-8661

Schlagwort(e): diffusion-weighted MRI ; susceptibility contrast MRI ; ischemia ; brain ; blood flow ; cat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin , Physik

Notizen: Abstract Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis.T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01705274

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Digitale Medien

Temporal evolution of focal cerebral ischemia in the rat assessed by T2-weighted and diffusion-weighted magnetic resonance imaging (1992)

Verheul, H. B. ; Berkelbach van der Sprenkel, J. W. ; Tulleken, C. A. F. ; [weitere]

Springer

Brain topography 5 (1992), S. 171-176

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ISSN: 1573-6792

Schlagwort(e): Cerebral ischemia ; Magnetic resonance imaging ; Brain edema ; Diffusion ; Rats

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The present study was undertaken to characterize the formation of ischemic brain edema using diffusion-weighted and T2-weighted magnetic resonance imaging in a rat model of focal ischemia. The extent of edema formation was measured from multislice diffusion-weighted and T2-weighted spin-echo images acquired at various times after ischemia. The spin-spin relaxation time (T2) and the apparent diffusion coefficient in normal and ischemic tissue were also determined. The results show that on the diffusion-weighted images the lesion was clearly visible at 30 minutes after ischemia, while on the T2-weighted images it became increasingly evident after 2–3 hours. On both types of images the hyperintense area increased in size over the first 48 hours. After 1 week the hyperintensity on the diffusion-weighted images rapidly disappeared and evolved as a hypointense lesion in the chronic phase. These results confirm the high sensitivity of diffusion-weighted MRI for the detection of early ischemia. The temporal course of the edema observed on T2W-images is in agreement with the reported increase of total water content occurring in this model. The increase of the lesion observed on the diffusion-weighted images during the first 2 days points to an aggravation of cytotoxic edema that parallels the changes in free water shown by the T2-weighted images. It is shown that the highly elevated T2's of the infarcted area several days after ischemia can substantially contaminate the diffusion-weighted images.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01129046

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