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  • Articles: DFG German National Licenses  (3)
  • placental transfer  (2)
  • Enzyme Induction  (1)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Transfer of nitrazepam across the human placenta (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 355-357 
    Details
    ISSN: 1432-1041
    Keywords: Nitrazepam ; placental transfer ; pharmacokinetics ; plasma levels ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six women from 14 to 17 weeks pregnant, and 12 woman from 36 to 40 weeks pregnant, were given nitrazepam 5 mg orally about 12 h before legal abortion by hysterotomy in the former group and elective caesarean section in the latter group. The concentration of nitrazepam was determined by gas-liquid chromatography. Binding to plasma proteins was evaluated by separation of the protein-free fraction by ultracentrifugation. In the first group (early pregnancy) the level of nitrazepam was found to be lower in the fetal than in the maternal circulation. The concentration in amniotic fluid was still lower. In the latter group (late pregnancy) the concentration both of unbound and total nitrazepam in maternal and fetal plasma were in equilibrium, which indicated an increase in transplacental transfer in late pregnancy. The percentage of unbound nitrazepam in both cases was 12%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562451
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Transfer of free and conjugated oxazepam across the human placenta (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 301-304 
    Details
    ISSN: 1432-1041
    Keywords: oxazepam ; oxazepam glucuronide ; placental transfer ; fetal drug level ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six women, 13 to 16 weeks pregnant, and 12 women at 38 to 40 weeks gestation, received oral oxazepam about 12 h before legal abortion, by hysterotomy in the former and before elective caesarean section in the latter group. The concentrations of free and conjugated oxazepam in maternal and fetal plasma were determined by gas-liquid chromatography. In early pregnancy the mean ratio between the plasma concentration of total (free + conjugated) drug in the umbilical cord and a maternal vein was 0.6, whereas in late pregnancy the ratio vein was 1.1. Both in early and late pregnancy, the free and glucuronide conjugate of oxazepam were found in the fetus at concentrations which indicated transplacental passage of the parent drug and its metabolite. There was great interindividual variation in the plasma levels both of free and conjugated oxazepam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625804
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration (1974)
    Springer
    Psychopharmacology 36 (1974), S. 123-131 
    Details
    ISSN: 1432-2072
    Keywords: Diazepam Therapy ; Enzyme Induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The plasma diazepam, N-demethyldiazepam, and free oxazepam concentrations were studied in 12 neurotic outpatients during subchronic use, in 14 outpatients after chronic use, and in 8 test subjects after an acute intravenous administration. There are several reasons for believing that diazepam may induce its own metabolism in man: 1. The decrease in diazepam and N-demethyldiazepam concentrations in the plasma after 1–6 weeks therapy. 2. Comparatively low plasma diazepam concentrations in patients who had taken diazepam for several months or years. 3. Much higher concentrations of N-demethyldiazepam, the main metabolite, after intravenously given diazepam in chronic users of diazepam as compared to controls. 4. The decrease in the ability to form N-demethyldiazepam after abstinence, when diazepam was administered intravenously to a chronic user of diazepam before and after the abstinence of the drug. Diazepam should be administered in small doses and for short periods of time only, or intermittently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421784
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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