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  • Articles: DFG German National Licenses  (2)
  • Extrahypothalamic neurons  (1)
  • Guinea pig  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The specificity of the response of preoptic-septal area neurons to estrogen: 17α-estradiol versus 17β-estradiol and the response of extrahypothalamic neurons (1977)
    Springer
    Experimental brain research 30 (1977), S. 43-52 
    Details
    ISSN: 1432-1106
    Keywords: Transport number ; Stereospecificity ; Preoptic area ; Extrahypothalamic neurons ; Estradiol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to determine the specificity of the response of medial preoptic-septal neurons (mPOA-S) to microelectrophoresed 17β-estradiol hemisuccinate (17βE2S). In vitro studies were conducted initially to determine the release of the labeled 17βE2S from multibarrel glass micropipettes. Subsequently, an isomer of 17βE2S, 17α-estradiol hemisuccinate (17αE2S), was synthesized and purified. Thirty-six mPOA-S neurons from normal cycling female rats were tested with both 17βE2S and 17αE2S. Twelve of these units responded with inhibition to 17βE2S, while none responded to 17αE2S. Furthermore, fifty extrahypothalamic (cortical, hippocampal, thalamic) neurons were tested with 17βE2S. The majority (N = 45) showed no response, three showed excitation and two inhibition to the microelectrophoresed steroid ester. These findings suggest that a specific receptor mechanism is responsible for the changes in mPOA-S unit activity, and that these effects may be important in the regulation of reproductive events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transynaptic transport of procion yellow in the central nervous system (1979)
    Springer
    Experimental brain research 35 (1979), S. 371-385 
    Details
    ISSN: 1432-1106
    Keywords: Transynaptic transport ; CNS ; Procion Yellow ; Guinea pig ; In vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular recordings were performed in slices of the lateral geniculate body, the visual cortex, and the hippocampus of guinea pigs. After recording, Procion Yellow was iontophoretically injected. During the injection period the neurones were activated antidromically and/or transynaptically. Up to 6 h after dye injection slices were fixed in a buffered formaldehyde/sucrose solution and later histologically processed. In the lateral geniculate body, after orthodromic stimulation across the optic tract, optic tract fibres were stained secondarily. Orthodromic activation across intrageniculate connections led to secondarily stained geniculate neurones. In the visual cortex orthodromic activation of the injected neurones across white matter led to secondarily stained fibres travelling in the direction to the white matter or to secondarily stained neurones in the vicinity of the injected neurone. In the hippocampus anti- and orthodromic activation across the alveus or the mossy fibre pathway led to a secondary staining of neighbouring pyramidal neurones and to a secondary staining of fibres which where afferent to the injected neurone. All slices where Procion Yellow was detected in the extracellular space were rejected. These findings led to the conclusion that Procion Yellow must have been transported across chemical synapses from the post- to the presynaptic side. The transport occurred only if the concerned synapses were activated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236621
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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