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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 228 (1980), S. 113-121 
    ISSN: 1434-4726
    Keywords: Gentamyzin-Ototoxizität ; Hörverlust ; Innenohrveränderungen ; Gentamicin ototoxicity ; Hearing loss ; Inner ear changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The long-term histological effects of gentamicin ototoxicity could be studied in a human being in relation to the audiometric impairment. The possible sequence of degeneration of hair cells, supporting cells, nerve fibers, stria vascularis, spiral ganglion cells, and vascular supply is discussed.
    Notes: Zusammenfassung Die histologischen Veränderungen an der menschlichen Kochlea nach acht Jahre zurückliegender hochdosierter Gentamyzin-Applikation bei an Taubheit grenzender Schwerhörigkeit, werden aufgezeigt. Folge der ototoxischen Wirkung von Gentamyzin ist zunächst eine Zerstörung der Sinneszellen im Cortischen Organ, denen eine solche der Stützzellen folgt. Dann verschwinden die Nervenfasern und die Zellen im Ganglion spirale und letztlich bleibt eine dünne Zellage auf der Basilarmembran. In der Stria vascularis sind dann bei Bildung von Zysten keine Gefäße mehr nachzuweisen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 69-73 
    ISSN: 1434-4726
    Keywords: Gentamicin ototoxicity ; Human inner ear ; Microdissection ; Surface preparation technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical, audiovestibular and histopathological findings in a patient who suffered from a long-standing gentamicin-induced deafness are reported. In both temporal bones, the organ of Corti was completely absent, with only a few nerve fibres remaining in the apical part of the cochlea. Regenerative ingrowth of nerve fibers into the area of the degenerative organ of Corti was present apically in both ears. The stria vascularis exhibited considerable degeneration in all turns and loss of microvasculature was found in the basilar membrane. The spiral ganglion cells, the cochlear nerve and the central auditory pathways and nuclei appeared to be unaffected.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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