ISSN:
1432-1238
Keywords:
Key words Heart surgery
;
Granulocyte
;
Hypoxanthine
;
Free radical
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective:To investigate granulocyte activation, as well as hypoxanthine and free radical production in children during the first day after cardiopulmonary bypass. Design: A prospective study of pediatric patients undergoing either cardiac surgery with a cardiopulmonary bypass or thoracotomy and extracardiac vascular surgery not requiring a cardiopulmonary bypass. Setting: Operative and intensive care units, Children’s Hospital, University of Helsinki, Finland. Patients: Seven consecutive patients undergoing elective correction of a ventricular septal defect and six patients undergoing extracardiac surgery for ligation of a patent ductus arteriosus or repair a coarctation of the aorta. Measurements and main results: Plasma concentrations of myeloperoxidase (140–334 μg/l preoperatively, 460–1692 μg/l at 0.2 h after declamping, 471–1386 μg/l at 0.5 h after declamping) and lactoferrin (77–258 μg/l preoperatively, 533–1783 at 0.2 h, 404–1482 μg/l at 0.5 h) as markers of granulocyte activation, and hypoxanthine (0–5.7 μmol/l preoperatively, 4.3–17.0 μmol/l at 0.2 h, 6.5–17.9 μmol/l at 0.5 h) increased in a biphasic manner at 0.2–0.5 h and 6–10 h postoperatively (all p〈0.05). Expired ethane, as an index of free radical activity, increased at 10 h postoperatively (36–119 pmol/kg per min preoperatively, 72–152 pmol/kg per min, p〈0.05). Conclusion: Granulocyte activation, and hypoxanthine and free radical production occur at least 10 h after cardiopulmonary bypass. In children undergoing open heart surgery, attempts to reduce free radical activity should be extended to the postoperative period.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01712176
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