ISSN:
1573-2568
Keywords:
TGF-α
;
STOMACH
;
DUODENUM
;
IMMUNOHISTOCHEMISTRY
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The maintenance of gastrointestinal epitheliumintegrity requires a fine balance between proliferationand differentiation as well as protection againstgastric acid secretion. Transforming growthfactor-α (TGF-α) regulates these functions bybinding to epidermal growth factor receptor (EGF-R).This study was designed to identify the localization ofTGF-α and EGF-R in the rat gastroduodenal region. In the stomach, the surface and gastric pitcells showed staining for TGF-α antibodies in thecytoplasm and basolateral and apical membranes.TGF-α and EGF-R were observed in the supranuclearregion of the cells lining the gland. In the duodenum,the enterocytes coexpressed both TGF-α and EGF-Rin the supranuclear area. The EGF-R was also observed inthe apical membrane. Brunner's glands were positive for both TGF-α and EGF-R antibodies. Ourresults demonstrate the coexpression of TGF-α andEGF-R in the rat gastroduodenal area, which suggests afunctional role for them in the establishment and maintenance of the epithelialrenewal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026655903294
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