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  • Articles: DFG German National Licenses  (2)
  • Key words Anti TGF-β receptor antibody  (1)
  • Local sweat rate  (1)
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  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 433 (1997), S. 675-678 
    ISSN: 1432-2013
    Keywords: Key words Long-term physical training ; Acclimation to heat ; Body temperature ; Frequency of sweat expulsion ; Local sweat rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Local sweat rates (M sw) at the chest and thigh and the frequency of sweat expulsions (F sw) were determined in human subjects with (athletes) or without (non-athletes) long-term physical training during moderate bicycle exercise (80 W for 30 min) at ambient thermoneutrality (23°C) and 60% relative humidity. There was a tendency for M sw to be lower in athletes. The rise of M sw with increasing F sw was significantly less steep and F sw was also controlled at a significantly lower rate in athletes than in non-athletes. The start of exercise was followed by a temporary decrease in mean skin temperature (T-s) which was less distinct in athletes. The rise in T-s at the end of exercise was significant in athletes (0.80 ± 0.26°C) but not in non-athletes (0.26 ± 0.33°C). The results indicate that long-term physical training leads to improved circulatory heat transfer to the skin and to a more graded nervous control of sweat expulsion and, further, tends to reduce the rate of sweating.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Key words Anti TGF-β receptor antibody ; Heat shock protein 70 ; Human skin fibroblast cell ; Transforming growth factor-β ; Ultraviolet B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ultraviolet B (UVB) alters the expression of heat shock protein 70 (HSP70) in cultured fibroblast cells derived from human skin. However, the nature of the signal transduction pathway remains to be determined. Transforming growth factor-β (TGF-β) has a large variety of biological functions, including cell growth control, modulation of inflammation and immunoregulation. In this study, we examined whether TGF-β is associated with the process of HSP70 expression induced by UVB irradiation. The constitutive expression of TGF-β1 mRNA and HSP70 expression in human skin fibroblast cells were detected using reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The results indicate that: (1) UVB irradiation stimulates HSP70 expression in a dose- and time-dependent manner, (2) constitutive expression of TGF-β1 mRNA is detected after UVB irradiation, the level of which peaks at 4 h after 10 mJ cm–2 of UVB irradiation, (3) HSP70 expression is induced by TGF-β1 without UVB irradiation, and (4) HSP70 expression induction with UVB irradiation is inhibited by preincubation of the cells with the anti-TGF-β type II receptor antibody. Our results suggest that HSP70 expression induced by UVB involves the autocrine signalling of TGF-β production.
    Type of Medium: Electronic Resource
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