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  • Articles: DFG German National Licenses  (19)
  • Spinacia  (10)
  • Schlüsselwörter Knochentumoren  (6)
  • Knochentumoren  (3)
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  • Articles: DFG German National Licenses  (19)
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  • 1
    Electronic Resource
    Electronic Resource
    The role of monovalent cations for photosynthesis of isolated intact chloroplasts (1980)
    Springer
    Planta 149 (1980), S. 170-175 
    Details
    ISSN: 1432-2048
    Keywords: Cations and photosynthesis ; Chloroplast (low-salt effects) ; Light activation (photosynthesis enzymes) ; Photosynthesis ; Spinacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The role of monovalent cations in the photosynthesis of isolated intact spinach chloroplasts was investigated. When intact chloroplasts were assayed in a medium containing only low concentrations of mono- and divalent cations (about 3 mval l-1), CO2-fixation was strongly inhibited although the intactness of chloroplasts remained unchanged. Addition of K+, Rb+, or Na+ (50–100 mM) fully restored photosynthesis. Both the degree of inhibition and restoration varied with the plant material and the storage time of the chloroplasts in “low-salt” medium. In most experiments the various monovalent cations showed a different effectiveness in restoring photosynthesis of low-salt chloroplasts (K+〉Rb+〉Na+). Of the divalent cations tested, Mg2+ also restored photosynthesis, but to a lesser extent than the monovalent cations. In contrast to CO2-fixation, reduction of 3-phosphoglycerate was not ihibited under low-salt conditions. In the dark, CO2-fixation of lysed chloroplasts supplied with ATP, NADPH, and 3-phosphoglycerate strictly required the presence of Mg2+ but was independent of monovalent cations. This finding excludes a direct inactivation of Calvin cycle enzymes as a possible basis for the inhibition of photosynthesis under low-salt conditions. Light-induced alkalization of the stroma and an increase in the concentration of freely exchangeable Mg2+ in the stroma, which can be observed in normal chloroplasts, did not occur under low-salt conditions but were strongly enhanced after addition of monovalent cations (50–100 mM) or Mg2+ (20–50 mM). The relevance of a light-triggered K+/H+ exchange at the chloroplast envelope is discussed with regard to the light-induced increase in the pH and the Mg2+ concentration in the stroma, which are thought to be obligatory for light activation of Calvincycle enzymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00380879
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  • 2
    Electronic Resource
    Electronic Resource
    Photosynthesis under osmotic stress (1981)
    Springer
    Planta 153 (1981), S. 430-435 
    Details
    ISSN: 1432-2048
    Keywords: Chloroplast ; Photosynthesis (stress recovery) ; Protoplast ; Spinacia ; Water stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The reversibility of the inhibition of photosynthetic reactions by water stress was examined with four systems of increasing complexity—stromal enzymes, intact chloroplasts, mesophyll protoplasts, and leaf slices. The inhibition of soluble chloroplast enzymes by high solute concentrations was instantly relieved when solutes were properly diluted. In contrast, photosynthesis was not restored but actually more inhibited when isolated chloroplasts exposed to hypertonic stress were transferred to conditions optimal for photosynthesis of unstressed chloroplasts. Upon transfer, chloroplast volumes increased beyond the volumes of unstressed chloroplasts, and partial envelope rupture occurred. In protoplasts and leaf slices, considerable and rapid, but incomplete restoration of photosynthesis was observed during transfer from hypertonic to isotonic conditions. Chloroplast envelopes did not rupture in situ during water uptake. It is concluded that inhibition of photosynthesis by severe water stress is at the biochemical level brought about in part by reversible inhibition of chloroplast enzymes and in part by membrane damage which requires repair mechanisms for reversibility. Both soluble enzymes and membranes appear to be affected by the increased concentration of internal solutes, which is caused by dehydration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394981
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  • 3
    Electronic Resource
    Electronic Resource
    Increased nitrate reductase activity in leaf tissue after application of the fungicide Kresoxim-methyl (1999)
    Springer
    Planta 207 (1999), S. 442-448 
    Details
    ISSN: 1432-2048
    Keywords: Key words: Nitrate reductase ; Respiration inhibitors ; Spinacia ; Strobilurin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Spinach (Spinacia oleracea L.) leaf discs floating on buffer solution were treated with Kresoxim-methyl (KROM), an inhibitor of respiratory electron transport. In the leaf tissue, actual and maximal nitrate reductase (NR) activities, nitrite content and ATP levels were determined. In darkened leaf discs incubated without KROM (control) actual NR activity decreased to 20% after 6 h in the dark. Treatment with 10 μg ml−1 (corresponding to 32 μM) KROM totally prevented inactivation of NR in the dark and also diminished NR-protein degradation during prolonged darkness. Due to restricted nitrite reduction in darkened leaf tissues, nitrite accumulated in KROM-treated discs. Inhibition of respiration decreased ATP and increased AMP levels in KROM-treated discs. In illuminated leaf discs, NR was highly activated to 65%. Nevertheless, KROM-treatment caused an additional activation of NR (activation state 76%) in the light. Possible side-effects of KROM on nitrite reduction and photosynthesis were also checked in the leaf-disc system. Neither nitrite reduction nor photosynthesis were altered in KROM-treated discs. The extent of KROM-induced activation of NR was dependent on the applied concentration and on the pH of the external medium. The highest activation of NR was achieved at an external pH of 4.8, confirming previous results (Kaiser and Brendle-Behnisch, 1995, Planta 196: 1–6) that cytosolic acidification might play an important role in the modulation of NR activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004250050503
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  • 4
    Electronic Resource
    Electronic Resource
    Acid-base-modulation of nitrate reductase in leaf tissues (1995)
    Springer
    Planta 196 (1995), S. 1-6 
    Details
    ISSN: 1432-2048
    Keywords: Acid-base loading ; Nitrate reductase ; pH regulation (intracellular) ; Protein phosphorylation ; Spinacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of acid or base-loading of spinach (Spinacia oleracea L.) leaf discs on the activation status of nitrate reductase (NR) in the dark and in the light was investigated. Activity of NR (NRA), measured in crude extracts of leaf discs with removed lower epidermis, which had been floating on Mes-buffer [2-(N-morpholino)ethane sulfonic acid] pH 5.2 in the dark, was at a similar low level as in whole, darkened leaves. By addition of acetate or propionic acid, butyric acid or benzoic acid, NR was activated to or beyond the light level. The pH of crude tissue extracts was decreased by 0.5–1 pH units. Tissue acidification caused an inhibition of photosynthesis and of dark CO2 fixation. The acid-induced activation of NR in vivo was largely prevented by okadaic acid, an inhibitor of Type 1 and Type 2A protein phosphatases. This indicates that acid-induced activation was mediated by protein dephosphorylation. When, on the other hand, leaf discs were illuminated on Ches-buffer (2-[ N-cyclohexylamino]ethane sulfonic acid) pH 9 in the presence of bicarbonate (80 mM), their NR was as active as in intact leaves. Addition of ammonium chloride (up to 6 mM) caused a pH increase of the tissue extract up to 0.9 pH units. At the same time NR was inactivated to the dark level. Methionine sulfoximine did not prevent the ammonium effect. Photosynthesis and dark CO2 fixation were stimulated at pH 9 by ammonium chloride (1–2· mol· m −3) and were only slightly inhibited by up to 6 mol· m−3. The modulation of NR by acid-base treatment in vivo was fully reversible. The response of the NR system to acid or base treatment is consistent with a proposed role of nitrate reduction in the cellular pH-stat. The observation also indicates that cytosolic pH changes may be involved the signal chain triggering the modulation of NR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193210
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  • 5
    Electronic Resource
    Electronic Resource
    Photosynthesis of isolated chloroplasts and protoplasts under osmotic stress (1981)
    Springer
    Planta 151 (1981), S. 375-380 
    Details
    ISSN: 1432-2048
    Keywords: Chloroplast volume ; Photosynthesis and chloroplast volume ; Spinacia ; Water stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. Isolated intact spinach chloroplasts respond to changes of the sorbitol concentration of the suspending medium as near-perfect osmometers within a large range of osmotic potentials. Under isotonic conditions (π=9–10 bar), their average osmotic volume is 24 μm3 and the total volume 36 μm3. The osmotic volume can be increased to 63 μm3 by lowering the sorbitol concentration until a critical osmotic potential of π=4 bar is reached. Below that value chloroplasts rupture. Between 10 bar and 4 bar, volume changes are reversible. 2. Increasing the chloroplast volume above 24 μm3 causes inhibition of photosynthesis, with 50% inhibition occurring at an osmotic potential of π=5–6 bar. This corresponds to an osmotic volume of 45–55 μm3. Depending on the duration of hypotonic treatment, inhibition of photosynthesis is more or less reversible. 3. Between 4 and 10 bar, the chloroplast envelope exhibits a very low permeability for ferricyanide, many metabolites, and soluble stroma proteins. 4. Electron transport is not inhibited by swelling of chloroplasts. Also, the ATP/ADP-ratio remains unchanged. 5. The solute concentration in the chloroplasts appears to be optimal for photosynthesis at 10 bar. Increasing the chloroplast volume causes inhibition of photosynthesis by dilution effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393294
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  • 6
    Electronic Resource
    Electronic Resource
    Das Klarzellchondrosarkom (2000)
    Springer
    Der Pathologe 21 (2000), S. 449-455 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Klarzellchondrosarkom ; Histologie ; Differenzialdiagnose ; Keywords Bone tumors ; Clear-cell chondrosarcoma ; Histology ; Differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Clear-cell chondrosarcoma is a rare, low-malignant bone tumor. The lesion most commonly occurs in adults, generally in the 3rd or 4th decade. Clear-cell chondrosarcoma has a predilection for the epiphyses of long tubular bones, particularly the femoral head. Radiologically, it is a sharply defined radiolucent lesion. Histologically, it is characterized by large tumor cells with distinct boundaries and a clear cytoplasm. In addition to areas of conventional chondrosarcoma, there are partially mineralized trabecular osteoid formations. On the basis of 16 cases of clear-cell chondrosarcoma, we present the observations of the Hamburg Bone Tumor Register. The cases were examined according to age distribution, location, and radiological and pathomorphological criteria. The proximal femur was the most frequent location; rare manifestations in the rib, os ilium, and distal phalanx of the hand were also present. In 50% of the cases high-malignant osteosarcoma or conventional chondrosarcoma was considered. In addition to the epiphysis of the proximal femur, clear-cell chondrosarcoma can also involve other, rather unusual sites in the skeleton. Knowledge of the histomorphology of this tumor is therefore of crucial importance for the diagnosis.
    Notes: Zusammenfassung Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor. Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade. Bevorzugte Lokalisation sind die Epiphysen langer Röhrenknochen, insbesondere der Femurkopf. Radiologisch imponiert es meist als eine epiphysär gelegene, scharf begrenzte lytische Läsion. Histologisch charakteristisch sind die großen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma. Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite, z. T. mineralisierte trabekuläre Osteoidformationen. Anhand von 16 Fällen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt. Die Fälle wurden nach Altersverteilung, Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht. Das Hauptmanifestationsalter lag innerhalb der 5.–7. Lebensdekade. Das proximale Femur stellte den Hauptlokalisationsort dar. Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe, Os ilium und Grundphalanx der Hand. In 50% der Fälle wurde auswärtig zunächst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert. Da das Klarzellchondrosarkom außer in der Epiphyse des proximalen Femurs auch an anderen, eher ungewöhnlichen Stellen des Skeletts auftreten kann, ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung für die Diagnosefindung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920000417
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  • 7
    Electronic Resource
    Electronic Resource
    Vergleichende DNA-zytometrische und zytogenetische Ploidie- bestimmungen an Chondro- sarkomen und Osteosarkomen (1996)
    Springer
    Der Pathologe 17 (1996), S. 374-379 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Chondrosarkom ; Osteosarkom ; Zytogenetik ; DNA-Zytometrie ; Ploidie ; Key words Bone neoplasms ; Chondrosarcoma ; Osteosarcoma ; Cytogenetics ; DNA-cytometry ; Ploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 10 chondrosarcomas and 10 osteosarcomas were examined using cytogenetics and DNA-image-cytometry. Cytogenetically 6 of 10 chondrosarcomas and 4 of 10 osteosarcomas showed hyperdiploid tumorcells. By DNA-cytometry in 8 of 10 chondrosarcomas and 9 of 10 osteosarcomas hyperdiploid tumorcells resp. hyperdiploid stemlines were detected. This discrepancy reflects an in-vitro-selection depending on the different entities. In 7 aneuploid clones of chondrosarcomas the chromosomal ploidy was calculated using the relative length of the chromosomes and compared with the DNA-ploidy of the native tumor. There was a close relation between both parameters of nuclear DNA-content. The interpretation of cytogenetic results is improved using a combination of karyotypic and DNA-cytometric examination. This is particularly important for the search for relations between numeric chromosomal aberrations and morphological parameters (grading).
    Notes: Zusammenfassung 10 Chondrosarkome und 10 Osteosarkome wurden tumorzytogenetisch und DNA-zytometrisch untersucht. Das Karyogramm erbrachte bei 6 von 10 Chondrosarkomen und bei 4 von 10 Osteosarkomen den Nachweis hyperdiploider Tumorzellklone. DNA-zytometrisch wurden am nativen Tumormaterial jedoch bei 8 von 10 Chondrosarkomen und bei 9 von 10 Osteosarkomen hyperdiploide Tumorzellen, häufig in Form eigenständiger hyperdiploider Stammlinien nachgewiesen. Diese Diskrepanz ist Ausdruck einer offenbar Entitäts-abhängigen In-vitro-Selektion. Bei insgesamt 7 aneuploiden Tumorzellklonen von Chondrosarkomen konnte die chromosomale Ploidie anhand der relativen Chromosomenlängen exakt errechnet und der zytometrisch bestimmten DNA-Ploidie gegenübergestellt werden, wobei sich eine sehr enge Abhängigkeit zwischen diesen beiden Parametern des nukleären DNA-Gehaltes ergab. Die Interpretation zytogenetischer Befunde bei Knochentumoren wird durch Kombination mit der DNA-Zytometrie verbessert. Dies ist besonders dann wichtig, wenn Zusammenhänge zwischen numerischen chromosomalen Aberrationen und morphologischen Parametern (z. B. Grading) dargestellt werden sollen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050175
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  • 8
    Electronic Resource
    Electronic Resource
    Das Chondromyxoidfibrom Morphologische Variationsbreite, Lokalisation, Häufigkeit, radiologische Kriterien und Differentialdiagnose (1999)
    Springer
    Der Pathologe 20 (1999), S. 224-229 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Chondromyxoidfibrom ; Histologie ; Key words Bone tumors ; Chondromyxoid fibroma ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Chondromyxoid fibroma is a rare benign bone tumor, accounting for less than 1% of all bone tumors. The peak age incidence is the second and third decade of life. Chondromyxoid fibrom occurs in the metaphyseal parts of the major tubular bones, predominantly of the lower extremity. Roentgenograms show, in most cases, a well-demarcated radiolucent lesion. The classic histological feature of a chondromyxoid fibroma is stellate or spindle-shaped cells arranged in lobules in a myxoid or chondroid background. Analysis of 40 chondromyxoid fibromas demonstrates the morphological variation of this tumor. Cases were examined for age distribution, localization, and radiological and histological features. In 85% we found the typical histomorphological pattern. Recurrence rate was 12.5%. In four cases the appearance was uncharacteristic and differentiation from other tumors such as chondroblastoma or chondrosarcoma was quite difficult. By adhering to strict histomorphological criteria, definite diagnosis of chondromyxoid fibroma can be made in most cases.
    Notes: Zusammenfassung Das Chondromyxoidfibrom ist ein seltener gutartiger Knochentumor. Seine Häufigkeit beträgt weniger als 1% aller primären Knochentumoren. Das Hauptmanifestationsalter ist die 2. und 3. Lebensdekade. Der Tumor ist überwiegend in der Metaphyse langer Röhrenknochen lokalisiert, insbesondere der unteren Extremität. Radiologisch stellt er in den meisten Fällen eine scharf begrenzte, osteolytische Läsion dar. Histologisch zeigt er einen lobulären Aufbau mit einer chondroiden oder myxoiden Grundmatrix. Die Zellen sind spindelig bis sternförmig. Anhand von 40 Chondromyxoidfibromen soll die morphologische Variationsbreite dieser Tumorentität dargestellt werden. Die Fälle wurden nach Altersverteilung, Lokalisation und radiologischen sowie pathomorphologischen Kriterien untersucht. In 85% der untersuchten Fälle fanden sich die typischen histomorphologischen Kriterien des Chondromyxoidfibroms. Bei 5 Patienten (12,5%) kam es zu einem Rezidiv. 4 Fälle zeigten ein uncharakteristisches Bild und waren nur bedingt von anderen Knochentumoren (Chondroblastom, Chondrosarkom) abzugrenzen. Bei Beachtung strenger histomorphologischer Kriterien aber kann die Diagnose Chondromyxoidfibrom in den meisten Fällen sicher gestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050349
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  • 9
    Electronic Resource
    Electronic Resource
    Morphologische Charakteristika des Chondroblastoms Eine retrospektive Untersuchung an 56 Fällen des Hamburger Knochentumorregisters (1996)
    Springer
    Der Pathologe 17 (1996), S. 26-34 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Chondroblastom ; Knochentumoren ; Immunhistologie ; Proliferation ; Key words Chondroblastoma ; Bone tumors ; Immunohistochemistry ; Proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Representing only about 1 % of all primary bone tumors, chondroblastoma constitutes a very rare bone tumor entity. 56 cases of chondroblastoma, that had been collected by the Hamburg Bone Tumor Registry from 1972 to 1995, were examined histologically together with the radiological and clinical findings. In addition immunohistochemistry with antibodies against S 100, PGM1, LCA and the proliferationmarker MIB 1 was performed. The mean age was 20.4 years and male patients being the majority with a gender ratio of 2.7 : 1. Predominant localisation was the epiphyses of the long bones, although almost 40 % of the tumors were located at untypical sites. Usually a well-circumscribed lysis could be seen on plain X-Ray examination, however partial cortical destruction could be observed in one third of the cases. Histologically characteristic was a polygonal cell component with a weblike chonroid matrix, sometimes with a plane-like appearance. 5 cases showed a distinct nuclear polymorphism making a distinction from osteosarcoma difficult. Using immunohistochemistry all tumors except for one showed positive reaction for S 100 protein. Although the histogenesis of chondroblastoma is not completely understood, morphological findings as well as the observed reactivity with the S 100 protein indicate the chondroid origin. No reactivity for PGM 1 (CD 68) or LCA could be detected. All chondroblastoma showed a low rate of proliferation, thereby being distinguishable from high malignant bone tumors. In general chondroblastoma show a benign biological behavior. Different behavior was observed in 2 cases. One relapse located in the pelvis revealed local aggressive growth while in another case in the humerus a malignant transformation had taken place.
    Notes: Zusammenfassung 56 Chondroblastome, die im Hamburger Knochentumorregister im Zeitraum von 1972 bis 1995 archiviert wurden, wurden retrospektiv histologisch untersucht, unter Berücksichtigung des radiologischen Befunds sowie der klinischen Angaben. Zusätzlich wurden immunhistologische Färbungen für S 100, PGM 1, LCA und den Proliferationsmarker MIB 1 durchgeführt. Das Durchschnittsalter der Patienten betrug 20,4 Jahre unter Bevorzugung männlicher Patienten mit einem Geschlechtsverhältnis von 2,7 : 1. Bevorzugter Lokalisationsort waren die Epiphysen der langen Röhrenknochen. Radiologisch stellt sich typischerweise eine umschriebene Lyse mit umgebendem Randsaum dar. Charakteristisch ist histologisch eine polygonale Zellkomponente mit einer netzartigen chondroiden Matrix. In 5 Fällen lag eine deutliche Kernpolymorphie vor, die eine Abgrenzung zum Osteosarkom schwierig machte. Immunhistologisch waren mit Ausnahme eines Falle alle Tumoren positiv für S 100. Allen Chondroblastomen war eine niedrige Proliferationsrate gemeinsam, die diese deutlich von hochmalignen Knochentumoren unterschied. Chrondroblastome besitzen üblicherweise ein gutartiges biologisches Verhalten. Zwei Fälle dieser Studie zeigten einen davon abweichenden Verlauf. Bei einem Rezidivtumor im Becken zeigte sich ein lokal aggressives Wachstum, in einem anderen Fall im Humerus war es zu einer malignen Transformation gekommen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050131
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  • 10
    Electronic Resource
    Electronic Resource
    Therapie-induzierte Veränderungen an Osteosarkomen nach neoadjuvanter Chemotherapie (Therapiestudie COSS 86) Beziehungen zwischen morphologischen Befunden und klinischem Verlauf (1996)
    Springer
    Der Pathologe 17 (1996), S. 35-43 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochentumoren ; Osteosarkom ; Neoadjuvante Chemotherapie ; Regressionsgrad ; Histologische Typisierung ; Tumorgröße ; Key words Bone neoplasms ; Osteosarcoma ; Neoadjuvant chemotherapy ; Degree of regression ; Histological typing ; Tumor size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 207 osteosarcomas were examined morphologically after neoadjuvant chemotherapy according to the COSS-86 protocol using representative slides of one whole tumor plane. The rate of responders 63 %. In relapse-free patients both the whole tumors and the vital areas there of were smaller than in patients with relapse during a follow-up period of 5 years. Within the subgroup of osteoblastic osteosarcomas, metastases were observed following smaller tumors than in chondroblastic osteosarcomas. Therefore, in addition to degree of regression, histological subtype and tumor size should be considered in the prognostic evaluation of osteosarcomas.
    Notes: Zusammenfassung Im Rahmen der kooperativen Osteosarkomstudie (COSS 86) wurden 207 Resektionspräparate von Osteosarkomen anhand der Auswertung einer Gesamttumorebene zur Bestimmung des Regressionsgrads morphologisch untersucht. Innerhalb der protokollgerecht auswertbaren Fälle betrug das Verhältnis zwischen Respondern und Nonrespondern 63 % : 37 %. Relapse-freie Patienten wiesen zum Zeitpunkt der Resektion einen kleineren Gesamttumor und geringere vitale Tumoranteile auf als Patienten mit einem metastasierenden Verlauf. Bei Berücksichtigung des histologischen Subtyps traten metastasierende Verläufe innerhalb einer Nachbeobachtungszeit von mindestens 5 Jahren in der Gruppe der osteoblastischen Osteosarkome bereits bei einer niedrigeren Gesamttumorgröße auf als bei den chondroblastischen Osteosarkomen. Bei der prognostischen Einschätzung von Osteosarkomen sollten deshalb neben dem Regressionsgrad als Parameter für das Ansprechen auf die Chemotherapie auch der histologische Aufbau und die Gesamttumorgröße Beachtung finden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050132
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