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  • Articles: DFG German National Licenses  (2)
  • Syrian golden hamster  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A fetal respiratory epithelial cell line for studying some problems of transplacental carcinogenesis in Syrian golden hamsters (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 133-144 
    Details
    ISSN: 1432-1335
    Keywords: Fetal lung epithelial cell line ; Differentiation ; MNNG transformation ; Syrian golden hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using repeated cloning and treatment with cis-HPL (200 μg/ml), an analogue of a procollagen precursor inhibitory to the growth of collagen-synthesizing cells of mesenchymal origin, clonally premature epithelial cell lines were isolated from fetal SGH lungs cultured on the 15th day of gestation. One of the cell lines, M3E3/C3, which has been extensively studied for biological characterization, developed poorly differentiated carcinomas in injected hamsters after transformation by MNNG. Moreover, when grown on collagen gel, this cell line indicated an obvious potency for in vitro differentiation in response to vitamin A by developing activated Golgi regions, well developed rER and a number of mucus-like granules. Since such a differentiative responses is expected to be definable in the light of respiratory epithelium developing in utero, this cell line may be useful for studying mechanisms of differentiation-dependent sensitivity of fetal organs to transplacental carcinogen exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402061
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters (1982)
    Springer
    Journal of cancer research and clinical oncology 102 (1982), S. 227-233 
    Details
    ISSN: 1432-1335
    Keywords: Vinylethylnitrosamine (VEN) ; Syrian golden hamster ; Respiratory tract tumors ; Vinyläthylnitrosamin (VEN) ; Syrische Goldhamster ; Tumoren im Respirationstrakt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Syrische Goldhamster erhielten wöchentlich 5,0, 2,5, 1,25 oder 0,63 mg/kg Körpergewicht Vinyläthylnitrosamin (VEN) subkutan. Mit ansteigender Dosis fand sich eine geringere mittlere Überlebenszeit; es zeigte sich eine Zunahme der Tumorrate. Bezüglich der Gesamttumorrate wurden Werte zwischen 50 und 100% ermittelt. Betroffen war insbesondere der Respirationstrakt, wobei sich zum Teil positive Dosis-Wirkungsbeziehungen ergaben.
    Notes: Summary Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract where a positive dose-response relationship was established for neoplastic growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411342
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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