ISSN:
1432-0428
Keywords:
Diabetes
;
albuminuria
;
extracellular matrix
;
heparan sulphate
;
vascular dysfunction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Albuminuria in Type 1 (insulin-dependent) diabetes is not only an indication of renal disease, but a new, independent risk-marker of proliferative retinopathy and macroangiopathy. The coincidence of generalised vascular dysfunction and albuminuria, advanced mesangial expansion, proliferative retinopathy, and severe macroangiopathy suggests a common cause of albuminuria and the severe renal and extrarenal complications associated with it. Enzymes involved in the metabolism of anionic components of the extracellular matrix (e.g. heparan sulphate proteoglycan) vulnerable to hyperglycaemia, seem to constitute the primary cause of albuminuria and the associated complications. Genetic polymorphism of such enzymes is possibly the main reason for variation in susceptibility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00285287
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