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Ca2+ and K+ current in cultured vascular smooth muscle cells from rat aorta (1987)

Toro, L. ; Stefani, E.

Springer

Pflügers Archiv 408 (1987), S. 417-419

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ISSN: 1432-2013

Keywords: Ca2+·currents ; K+ currents ; vascular smooth muscle ; rat aorta

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Ca2+ (ICa) and K+ (IK) currents were recorded in single cultured cells from rat aorta using the whole cell clamp technique with patch electrodes. ICa was detected at−30 mV, and at 20 mV it reached a peak in about 10 ms and decayed with a t1/2=50 ms. The mean maximum slope conductance (GCa) was 30 μS/cm2. IK was detected at−10 mV and at 20 mV reached its maximum with a t1/2=12 ms. For IK, GK=200 μS/cm2. These channels can be activated during action potentials and play a role in the excitation and contraction of vascular smooth muscle cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00581139

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